LRRN2 (leucine rich repeat neuronal 2)

Gene

• Entrez ID: 10446
• Gene name: Leucine rich repeat neuronal 2
• Gene symbol: LRRN2
• Synonyms: FIGLER7, GAC1, LRANK1, LRRN5
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039294	hsa-miR-671-5p	CLASH	23622248
MIRT1120942	hsa-miR-1273f	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT1120944	hsa-miR-1343	CLIP-seq
MIRT1120945	hsa-miR-143	CLIP-seq
MIRT1120946	hsa-miR-150	CLIP-seq
MIRT1120947	hsa-miR-205	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT1120949	hsa-miR-3197	CLIP-seq
MIRT1120950	hsa-miR-324-5p	CLIP-seq
MIRT1120951	hsa-miR-3942-3p	CLIP-seq
MIRT1120952	hsa-miR-3945	CLIP-seq
MIRT1120953	hsa-miR-4253	CLIP-seq
MIRT1120954	hsa-miR-4663	CLIP-seq
MIRT1120955	hsa-miR-4708-5p	CLIP-seq
MIRT1120956	hsa-miR-4713-5p	CLIP-seq
MIRT1120957	hsa-miR-4770	CLIP-seq
MIRT1120958	hsa-miR-532-3p	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT1120960	hsa-miR-642a	CLIP-seq
MIRT1120961	hsa-miR-3616-3p	CLIP-seq
MIRT1120962	hsa-miR-3669	CLIP-seq
MIRT1120963	hsa-miR-3689d	CLIP-seq
MIRT1120964	hsa-miR-3943	CLIP-seq
MIRT1120965	hsa-miR-4436b-3p	CLIP-seq
MIRT1120966	hsa-miR-4721	CLIP-seq
MIRT1120967	hsa-miR-515-5p	CLIP-seq
MIRT1120968	hsa-miR-548m	CLIP-seq
MIRT1120969	hsa-miR-642b	CLIP-seq
MIRT2034241	hsa-miR-4459	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2264696	hsa-miR-326	CLIP-seq
MIRT2264697	hsa-miR-330-5p	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120954	hsa-miR-4663	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT2453419	hsa-miR-3150a-3p	CLIP-seq
MIRT2453420	hsa-miR-3175	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2453421	hsa-miR-3612	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2453422	hsa-miR-650	CLIP-seq
MIRT2453423	hsa-miR-939	CLIP-seq
MIRT2264695	hsa-miR-1253	CLIP-seq
MIRT1120943	hsa-miR-1285	CLIP-seq
MIRT2453419	hsa-miR-3150a-3p	CLIP-seq
MIRT2453420	hsa-miR-3175	CLIP-seq
MIRT1120948	hsa-miR-3187-5p	CLIP-seq
MIRT2453421	hsa-miR-3612	CLIP-seq
MIRT2264698	hsa-miR-378g	CLIP-seq
MIRT2264699	hsa-miR-4426	CLIP-seq
MIRT2264700	hsa-miR-4486	CLIP-seq
MIRT2264701	hsa-miR-4647	CLIP-seq
MIRT2264702	hsa-miR-4662b	CLIP-seq
MIRT1120959	hsa-miR-612	CLIP-seq
MIRT2453422	hsa-miR-650	CLIP-seq
MIRT2453423	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0007155	Process	Cell adhesion	TAS	9662332
GO:0007165	Process	Signal transduction	TAS	9662332
GO:0016021	Component	Integral component of membrane	IEA
GO:0031012	Component	Extracellular matrix	IBA	21873635
GO:0038023	Function	Signaling receptor activity	TAS	9662332

Other IDs

• MIM: 605492
• HGNC: 16914
• e!Ensembl: ENSG00000170382

Protein

• UniProt ID: O75325
• Protein name: Leucine-rich repeat neuronal protein 2 (Glioma amplified on chromosome 1 protein) (Leucine-rich repeat neuronal protein 5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	69 → 129	Leucine rich repeat	Repeat
  PF13855	LRR_8	93 → 153	Leucine rich repeat	Repeat
  PF13855	LRR_8	117 → 177	Leucine rich repeat	Repeat
  PF13855	LRR_8	213 → 273	Leucine rich repeat	Repeat
  PF13855	LRR_8	310 → 371	Leucine rich repeat	Repeat
  PF07679	I-set	427 → 514	Immunoglobulin I-set domain	Domain

• Sequence:

  MRLLVAPLLLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFL
  TAVPPALPAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLL
  SLHLEENQLTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAI
  DSRWFEMLPNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLE
  SLSFYDNQLARVPRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVS
  IDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPN
  LQEVGLHGNPIRCDCVIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHC
  LPLISPRSFPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEG
  TLELRRVTAEEAGLYTCVAQNLVGADTKTVSVVVGRALLQPGRDEGQGLELRVQETHPYH
  ILLSWVTPPNTVSTNLTWSSASSLRGQGATALARLPRGTHSYNITRLLQATEYWACLQVA
  FADAHTQLACVWARTKEATSCHRALGDRPGLIAILALAVLLLAAGLAAHLGTGQPRKGVG
  GRRPLPPAWAFWGWSAPSVRVVSAPLVLPWNPGRKLPRSSEGETLLPPLSQNS

• Sequence length: 713

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203