OLFM1 (olfactomedin 1)

Gene

• Entrez ID: 10439
• Gene name: Olfactomedin 1
• Gene symbol: OLFM1
• Synonyms: AMY, NOE1, NOELIN1, OlfA
• Chromosome: 9
• Chromosome location: 9q34.3
• Summary: This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT733175	hsa-miR-200a-3p	RNA-seq, qRT-PCR	33968190
MIRT1203020	hsa-miR-1206	CLIP-seq
MIRT1203021	hsa-miR-1224-5p	CLIP-seq
MIRT1203022	hsa-miR-1271	CLIP-seq
MIRT1203023	hsa-miR-1289	CLIP-seq
MIRT1203024	hsa-miR-132	CLIP-seq
MIRT1203025	hsa-miR-141	CLIP-seq
MIRT1203026	hsa-miR-146a	CLIP-seq
MIRT1203027	hsa-miR-146b-5p	CLIP-seq
MIRT1203028	hsa-miR-182	CLIP-seq
MIRT1203029	hsa-miR-193a-3p	CLIP-seq
MIRT1203030	hsa-miR-193b	CLIP-seq
MIRT1203031	hsa-miR-200a	CLIP-seq
MIRT1203032	hsa-miR-204	CLIP-seq
MIRT1203033	hsa-miR-211	CLIP-seq
MIRT1203034	hsa-miR-2114	CLIP-seq
MIRT1203035	hsa-miR-212	CLIP-seq
MIRT1203036	hsa-miR-27a	CLIP-seq
MIRT1203037	hsa-miR-27b	CLIP-seq
MIRT1203038	hsa-miR-296-5p	CLIP-seq
MIRT1203039	hsa-miR-299-3p	CLIP-seq
MIRT1203040	hsa-miR-3120-3p	CLIP-seq
MIRT1203041	hsa-miR-3121-5p	CLIP-seq
MIRT1203042	hsa-miR-3152-5p	CLIP-seq
MIRT1203043	hsa-miR-329	CLIP-seq
MIRT1203044	hsa-miR-362-3p	CLIP-seq
MIRT1203045	hsa-miR-3679-3p	CLIP-seq
MIRT1203046	hsa-miR-3926	CLIP-seq
MIRT1203047	hsa-miR-3941	CLIP-seq
MIRT1203048	hsa-miR-4256	CLIP-seq
MIRT1203049	hsa-miR-4265	CLIP-seq
MIRT1203050	hsa-miR-4296	CLIP-seq
MIRT1203051	hsa-miR-4317	CLIP-seq
MIRT1203052	hsa-miR-4322	CLIP-seq
MIRT1203053	hsa-miR-4417	CLIP-seq
MIRT1203054	hsa-miR-4423-5p	CLIP-seq
MIRT1203055	hsa-miR-4433	CLIP-seq
MIRT1203056	hsa-miR-4436b-5p	CLIP-seq
MIRT1203057	hsa-miR-4446-5p	CLIP-seq
MIRT1203058	hsa-miR-4477a	CLIP-seq
MIRT1203059	hsa-miR-452	CLIP-seq
MIRT1203060	hsa-miR-4639-3p	CLIP-seq
MIRT1203061	hsa-miR-4670-3p	CLIP-seq
MIRT1203062	hsa-miR-4676-3p	CLIP-seq
MIRT1203063	hsa-miR-4707-5p	CLIP-seq
MIRT1203064	hsa-miR-4709-5p	CLIP-seq
MIRT1203065	hsa-miR-4710	CLIP-seq
MIRT1203066	hsa-miR-4714-5p	CLIP-seq
MIRT1203067	hsa-miR-4724-5p	CLIP-seq
MIRT1203068	hsa-miR-4751	CLIP-seq
MIRT1203069	hsa-miR-4783-3p	CLIP-seq
MIRT1203070	hsa-miR-4792	CLIP-seq
MIRT1203071	hsa-miR-4795-3p	CLIP-seq
MIRT1203072	hsa-miR-513a-5p	CLIP-seq
MIRT1203073	hsa-miR-548aa	CLIP-seq
MIRT1203074	hsa-miR-548ac	CLIP-seq
MIRT1203075	hsa-miR-548d-3p	CLIP-seq
MIRT1203076	hsa-miR-548g	CLIP-seq
MIRT1203077	hsa-miR-548s	CLIP-seq
MIRT1203078	hsa-miR-548z	CLIP-seq
MIRT1203079	hsa-miR-589	CLIP-seq
MIRT1203080	hsa-miR-591	CLIP-seq
MIRT1203081	hsa-miR-593	CLIP-seq
MIRT1203082	hsa-miR-603	CLIP-seq
MIRT1203083	hsa-miR-616	CLIP-seq
MIRT1203084	hsa-miR-629	CLIP-seq
MIRT1203085	hsa-miR-654-3p	CLIP-seq
MIRT1203086	hsa-miR-718	CLIP-seq
MIRT1203087	hsa-miR-885-3p	CLIP-seq
MIRT1203088	hsa-miR-891b	CLIP-seq
MIRT1203089	hsa-miR-96	CLIP-seq
MIRT1203024	hsa-miR-132	CLIP-seq
MIRT1203025	hsa-miR-141	CLIP-seq
MIRT1203031	hsa-miR-200a	CLIP-seq
MIRT1203035	hsa-miR-212	CLIP-seq
MIRT1203022	hsa-miR-1271	CLIP-seq
MIRT1203028	hsa-miR-182	CLIP-seq
MIRT1203036	hsa-miR-27a	CLIP-seq
MIRT1203037	hsa-miR-27b	CLIP-seq
MIRT1203055	hsa-miR-4433	CLIP-seq
MIRT1203072	hsa-miR-513a-5p	CLIP-seq
MIRT1203087	hsa-miR-885-3p	CLIP-seq
MIRT1203089	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003190	Process	Atrioventricular valve formation	ISS
GO:0005515	Function	Protein binding	IPI	17043677, 31413325
GO:0005615	Component	Extracellular space	ISS
GO:0005783	Component	Endoplasmic reticulum	ISS
GO:0007399	Process	Nervous system development	IEA
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0010629	Process	Negative regulation of gene expression	ISS
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	ISS
GO:0023041	Process	Neuronal signal transduction	ISS
GO:0030424	Component	Axon	ISS
GO:0030516	Process	Regulation of axon extension	ISS
GO:0043025	Component	Neuronal cell body	ISS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	16751333
GO:0043204	Component	Perikaryon	IEA
GO:0044295	Component	Axonal growth cone	ISS
GO:0045202	Component	Synapse	IEA
GO:0060317	Process	Cardiac epithelial to mesenchymal transition	ISS

Other IDs

• MIM: 605366
• HGNC: 17187
• e!Ensembl: ENSG00000130558

Protein

• UniProt ID: Q99784
• Protein name: Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1)
• Protein function: Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role i
• PDB: 4XAT, 6QHJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12308	Noelin-1	54 → 153	Neurogenesis glycoprotein	Family
  PF02191	OLF	230 → 476	Olfactomedin-like domain	Family

• Sequence:

  MSVPLLKIGVVLSTMAMITNWMSQTLPSLVGLNTTKLSAAGGGTLDRSTGVLPTNPEESW
  QVYSSAQDSEGRCICTVVAPQQTMCSRDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQ
  YVEKMENQMKGLESKFKQVEESHKQHLARQFKAIKAKMDELRPLIPVLEEYKADAKLVLQ
  FKEEVQNLTSVLNELQEEIGAYDYDELQSRVSNLEERLRACMQKLACGKLTGISDPVTVK
  TSGSRFGSWMTDPLAPEGDNRVWYMDGYHNNRFVREYKSMVDFMNTDNFTSHRLPHPWSG
  TGQVVYNGSIYFNKFQSHIIIRFDLKTETILKTRSLDYAGYNNMYHYAWGGHSDIDLMVD
  ESGLWAVYATNQNAGNIVVSRLDPVSLQTLQTWNTSYPKRSAGEAFIICGTLYVTNGYSG
  GTKVHYAYQTNASTYEYIDIPFQNKYSHISMLDYNPKDRALYAWNNGHQILYNVTLFHVI
  RSDEL

• Sequence length: 485

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	19208208

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		19208208