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TESK2 (testis associated actin remodelling kinase 2)

Gene

Testis associated actin remodelling kinase 2

TESK2

1p34.1

This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overa

Show/Hide all(198)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021469	hsa-miR-9-5p	Microarray	17612493
MIRT031008	hsa-miR-21-5p	Microarray	18591254
MIRT038778	hsa-miR-93-3p	CLASH	23622248
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	20371350
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	20371350
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	20371350
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	20371350
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	20371350
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	20371350
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	20371350
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	20371350
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	20371350
MIRT488212	hsa-miR-485-3p	PAR-CLIP	20371350
MIRT488211	hsa-miR-539-3p	PAR-CLIP	20371350
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	20371350
MIRT512865	hsa-miR-6768-5p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23446348
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23446348
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23446348
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23446348
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23446348
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	23446348
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	23446348
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	23446348
MIRT512861	hsa-miR-4672	PAR-CLIP	23446348
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23446348
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23446348
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23592263
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23592263
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23592263
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23592263
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23592263
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	20371350
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	20371350
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	20371350
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	20371350
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	20371350
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	20371350
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	20371350
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	20371350
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	20371350
MIRT488212	hsa-miR-485-3p	PAR-CLIP	20371350
MIRT488211	hsa-miR-539-3p	PAR-CLIP	20371350
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	20371350
MIRT512865	hsa-miR-6768-5p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23446348
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23446348
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23446348
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23446348
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23446348
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23446348
MIRT512864	hsa-miR-6882-3p	PAR-CLIP	23446348
MIRT512863	hsa-miR-4757-5p	PAR-CLIP	23446348
MIRT512862	hsa-miR-6744-3p	PAR-CLIP	23446348
MIRT512861	hsa-miR-4672	PAR-CLIP	23446348
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23446348
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23446348
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23446348
MIRT488218	hsa-miR-6890-3p	PAR-CLIP	23592263
MIRT488217	hsa-miR-1247-5p	PAR-CLIP	23592263
MIRT488216	hsa-miR-1304-3p	PAR-CLIP	23592263
MIRT488215	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT488213	hsa-miR-6791-3p	PAR-CLIP	23592263
MIRT488214	hsa-miR-6829-3p	PAR-CLIP	23592263
MIRT488212	hsa-miR-485-3p	PAR-CLIP	23592263
MIRT488211	hsa-miR-539-3p	PAR-CLIP	23592263
MIRT488210	hsa-miR-6836-3p	PAR-CLIP	23592263
MIRT1418510	hsa-miR-1207-3p	CLIP-seq
MIRT1418511	hsa-miR-1207-5p	CLIP-seq
MIRT1418512	hsa-miR-130a	CLIP-seq
MIRT1418513	hsa-miR-130b	CLIP-seq
MIRT1418514	hsa-miR-142-3p	CLIP-seq
MIRT1418515	hsa-miR-1910	CLIP-seq
MIRT1418516	hsa-miR-19a	CLIP-seq
MIRT1418517	hsa-miR-19b	CLIP-seq
MIRT1418518	hsa-miR-2110	CLIP-seq
MIRT1418519	hsa-miR-2114	CLIP-seq
MIRT1418520	hsa-miR-301a	CLIP-seq
MIRT1418521	hsa-miR-301b	CLIP-seq
MIRT1418522	hsa-miR-302a	CLIP-seq
MIRT1418523	hsa-miR-302b	CLIP-seq
MIRT1418524	hsa-miR-302c	CLIP-seq
MIRT1418525	hsa-miR-302d	CLIP-seq
MIRT1418526	hsa-miR-302e	CLIP-seq
MIRT1418527	hsa-miR-31	CLIP-seq
MIRT1418528	hsa-miR-3120-3p	CLIP-seq
MIRT1418529	hsa-miR-3121-3p	CLIP-seq
MIRT1418530	hsa-miR-3133	CLIP-seq
MIRT1418531	hsa-miR-3153	CLIP-seq
MIRT1418532	hsa-miR-3202	CLIP-seq
MIRT1418533	hsa-miR-339-5p	CLIP-seq
MIRT1418534	hsa-miR-340	CLIP-seq
MIRT1418535	hsa-miR-342-5p	CLIP-seq
MIRT1418536	hsa-miR-3647-3p	CLIP-seq
MIRT1418537	hsa-miR-3661	CLIP-seq
MIRT1418538	hsa-miR-3666	CLIP-seq
MIRT1418539	hsa-miR-372	CLIP-seq
MIRT1418540	hsa-miR-373	CLIP-seq
MIRT1418541	hsa-miR-421	CLIP-seq
MIRT1418542	hsa-miR-4256	CLIP-seq
MIRT1418543	hsa-miR-4271	CLIP-seq
MIRT1418544	hsa-miR-4275	CLIP-seq
MIRT1418545	hsa-miR-4295	CLIP-seq
MIRT1418546	hsa-miR-4476	CLIP-seq
MIRT1418547	hsa-miR-4517	CLIP-seq
MIRT1418548	hsa-miR-4527	CLIP-seq
MIRT1418549	hsa-miR-454	CLIP-seq
MIRT1418550	hsa-miR-455-3p	CLIP-seq
MIRT1418551	hsa-miR-4651	CLIP-seq
MIRT1418552	hsa-miR-4655-5p	CLIP-seq
MIRT1418553	hsa-miR-4664-5p	CLIP-seq
MIRT1418554	hsa-miR-4709-5p	CLIP-seq
MIRT1418555	hsa-miR-4725-3p	CLIP-seq
MIRT1418556	hsa-miR-4736	CLIP-seq
MIRT1418557	hsa-miR-4763-3p	CLIP-seq
MIRT1418558	hsa-miR-491-5p	CLIP-seq
MIRT1418559	hsa-miR-493	CLIP-seq
MIRT1418560	hsa-miR-519a	CLIP-seq
MIRT1418561	hsa-miR-519b-3p	CLIP-seq
MIRT1418562	hsa-miR-519c-3p	CLIP-seq
MIRT1418563	hsa-miR-520a-3p	CLIP-seq
MIRT1418564	hsa-miR-520b	CLIP-seq
MIRT1418565	hsa-miR-520c-3p	CLIP-seq
MIRT1418566	hsa-miR-520d-3p	CLIP-seq
MIRT1418567	hsa-miR-520e	CLIP-seq
MIRT1418568	hsa-miR-548b-3p	CLIP-seq
MIRT1418569	hsa-miR-548c-3p	CLIP-seq
MIRT1418570	hsa-miR-568	CLIP-seq
MIRT1418571	hsa-miR-584	CLIP-seq
MIRT1418572	hsa-miR-591	CLIP-seq
MIRT1418573	hsa-miR-608	CLIP-seq
MIRT1418574	hsa-miR-631	CLIP-seq
MIRT1418575	hsa-miR-766	CLIP-seq
MIRT1418576	hsa-miR-888	CLIP-seq
MIRT1418514	hsa-miR-142-3p	CLIP-seq
MIRT2125522	hsa-miR-153	CLIP-seq
MIRT2125523	hsa-miR-383	CLIP-seq
MIRT2125524	hsa-miR-4436b-5p	CLIP-seq
MIRT2125525	hsa-miR-448	CLIP-seq
MIRT2125526	hsa-miR-4716-5p	CLIP-seq
MIRT2125527	hsa-miR-4772-5p	CLIP-seq
MIRT2347870	hsa-miR-1182	CLIP-seq
MIRT2347871	hsa-miR-1247	CLIP-seq
MIRT2347872	hsa-miR-1287	CLIP-seq
MIRT2347873	hsa-miR-1290	CLIP-seq
MIRT1418512	hsa-miR-130a	CLIP-seq
MIRT1418513	hsa-miR-130b	CLIP-seq
MIRT2347874	hsa-miR-1827	CLIP-seq
MIRT1418515	hsa-miR-1910	CLIP-seq
MIRT1418516	hsa-miR-19a	CLIP-seq
MIRT1418517	hsa-miR-19b	CLIP-seq
MIRT1418520	hsa-miR-301a	CLIP-seq
MIRT1418521	hsa-miR-301b	CLIP-seq
MIRT1418522	hsa-miR-302a	CLIP-seq
MIRT1418523	hsa-miR-302b	CLIP-seq
MIRT1418524	hsa-miR-302c	CLIP-seq
MIRT1418525	hsa-miR-302d	CLIP-seq
MIRT1418526	hsa-miR-302e	CLIP-seq
MIRT1418528	hsa-miR-3120-3p	CLIP-seq
MIRT1418531	hsa-miR-3153	CLIP-seq
MIRT2347875	hsa-miR-3167	CLIP-seq
MIRT2347876	hsa-miR-3188	CLIP-seq
MIRT1418532	hsa-miR-3202	CLIP-seq
MIRT2347877	hsa-miR-3612	CLIP-seq
MIRT1418538	hsa-miR-3666	CLIP-seq
MIRT2347878	hsa-miR-3689a-3p	CLIP-seq
MIRT2347879	hsa-miR-3689c	CLIP-seq
MIRT1418539	hsa-miR-372	CLIP-seq
MIRT1418540	hsa-miR-373	CLIP-seq
MIRT2347880	hsa-miR-3942-3p	CLIP-seq
MIRT2347881	hsa-miR-4257	CLIP-seq
MIRT1418544	hsa-miR-4275	CLIP-seq
MIRT1418545	hsa-miR-4295	CLIP-seq
MIRT2347882	hsa-miR-4299	CLIP-seq
MIRT2347883	hsa-miR-4456	CLIP-seq
MIRT1418546	hsa-miR-4476	CLIP-seq
MIRT1418549	hsa-miR-454	CLIP-seq
MIRT1418550	hsa-miR-455-3p	CLIP-seq
MIRT2347884	hsa-miR-4728-5p	CLIP-seq
MIRT1418560	hsa-miR-519a	CLIP-seq
MIRT1418561	hsa-miR-519b-3p	CLIP-seq
MIRT1418562	hsa-miR-519c-3p	CLIP-seq
MIRT1418563	hsa-miR-520a-3p	CLIP-seq
MIRT1418564	hsa-miR-520b	CLIP-seq
MIRT1418565	hsa-miR-520c-3p	CLIP-seq
MIRT1418566	hsa-miR-520d-3p	CLIP-seq
MIRT1418567	hsa-miR-520e	CLIP-seq
MIRT2347885	hsa-miR-541	CLIP-seq
MIRT2347886	hsa-miR-548q	CLIP-seq
MIRT2347887	hsa-miR-650	CLIP-seq
MIRT2347888	hsa-miR-654-5p	CLIP-seq
MIRT2347889	hsa-miR-876-5p	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004672	Function	Protein kinase activity	TAS	10512679
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	ISS
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0006468	Process	Protein phosphorylation	ISS
GO:0007283	Process	Spermatogenesis	ISS
GO:0016604	Component	Nuclear body	IDA
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA	21873635
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048041	Process	Focal adhesion assembly	ISS

MIM	HGNC	e!Ensembl
604746	11732	ENSG00000070759

Protein

UniProt ID

Q96S53

Protein name

Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2)

Protein function

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07714	PK_Tyr_Ser-Thr	59 → 309	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MDRSKRNSIAGFPPRVERLEEFEGGGGGEGNVSQVGRVWPSSYRALISAFSRLTRLDDFT
CEKIGSGFFSEVFKVRHRASGQVMALKMNTLSSNRANMLKEVQLMNRLSHPNILRFMGVC
VHQGQLHALTEYINSGNLEQLLDSNLHLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSK
NCLIKRDENGYSAVVADFGLAEKIPDVSMGSEKLAVVGSPFWMAPEVLRDEPYNEKADVF
SYGIILCEIIARIQADPDYLPRTENFGLDYDAFQHMVGDCPPDFLQLTFNCCNMDPKLRP
SFVEIGKTLEEILSRLQEEEQERDRKLQPTARGLLEKAPGVKRLSSLDDKIPHKSPCPRR
TIWLSRSQSDIFSRKPPRTVSVLDPYYRPRDGAARTPKVNPFSARQDLMGGKIKFFDLPS
KSVISLVFDLDAPGPGTMPLADWQEPLAPPIRRWRSLPGSPEFLHQEACPFVGREESLSD
GPPPRLSSLKYRVKEIPPFRASALPAAQAHEAMDCSILQEENGFGSRPQGTSPCPAGASE
EMEVEERPAGSTPATFSTSGIGLQTQGKQDG

Sequence length

571

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	30804561

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Infiltrating duct carcinoma of female breast	Infiltrating duct carcinoma of female breast

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