CDSN (corneodesmosin)

Gene

• Entrez ID: 1041
• Gene name: Corneodesmosin
• Gene symbol: CDSN
• Synonyms: HTSS, HTSS1, HYPT2, PSS, PSS1
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human pop

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT882617	hsa-miR-1	CLIP-seq
MIRT882618	hsa-miR-1208	CLIP-seq
MIRT882619	hsa-miR-1245b-3p	CLIP-seq
MIRT882620	hsa-miR-206	CLIP-seq
MIRT882621	hsa-miR-3125	CLIP-seq
MIRT882622	hsa-miR-3165	CLIP-seq
MIRT882623	hsa-miR-3179	CLIP-seq
MIRT882624	hsa-miR-3180-5p	CLIP-seq
MIRT882625	hsa-miR-3184	CLIP-seq
MIRT882626	hsa-miR-3186-5p	CLIP-seq
MIRT882627	hsa-miR-3202	CLIP-seq
MIRT882628	hsa-miR-3673	CLIP-seq
MIRT882629	hsa-miR-3677-5p	CLIP-seq
MIRT882630	hsa-miR-3916	CLIP-seq
MIRT882631	hsa-miR-3937	CLIP-seq
MIRT882632	hsa-miR-3974	CLIP-seq
MIRT882633	hsa-miR-423-5p	CLIP-seq
MIRT882634	hsa-miR-4252	CLIP-seq
MIRT882635	hsa-miR-4271	CLIP-seq
MIRT882636	hsa-miR-4276	CLIP-seq
MIRT882637	hsa-miR-4318	CLIP-seq
MIRT882638	hsa-miR-4476	CLIP-seq
MIRT882639	hsa-miR-4512	CLIP-seq
MIRT882640	hsa-miR-452	CLIP-seq
MIRT882641	hsa-miR-4656	CLIP-seq
MIRT882642	hsa-miR-4676-3p	CLIP-seq
MIRT882643	hsa-miR-4688	CLIP-seq
MIRT882644	hsa-miR-4697-3p	CLIP-seq
MIRT882645	hsa-miR-4701-5p	CLIP-seq
MIRT882646	hsa-miR-4725-3p	CLIP-seq
MIRT882647	hsa-miR-4778-3p	CLIP-seq
MIRT882648	hsa-miR-4796-3p	CLIP-seq
MIRT882649	hsa-miR-520a-5p	CLIP-seq
MIRT882650	hsa-miR-525-5p	CLIP-seq
MIRT882651	hsa-miR-548t	CLIP-seq
MIRT882652	hsa-miR-588	CLIP-seq
MIRT882653	hsa-miR-613	CLIP-seq
MIRT1961523	hsa-miR-198	CLIP-seq
MIRT1961524	hsa-miR-2110	CLIP-seq
MIRT1961525	hsa-miR-219-2-3p	CLIP-seq
MIRT1961526	hsa-miR-3122	CLIP-seq
MIRT1961527	hsa-miR-3127-5p	CLIP-seq
MIRT1961528	hsa-miR-3144-5p	CLIP-seq
MIRT1961529	hsa-miR-3147	CLIP-seq
MIRT1961530	hsa-miR-3150a-3p	CLIP-seq
MIRT1961531	hsa-miR-3173-3p	CLIP-seq
MIRT1961532	hsa-miR-3191	CLIP-seq
MIRT1961533	hsa-miR-3619-3p	CLIP-seq
MIRT1961534	hsa-miR-3650	CLIP-seq
MIRT1961535	hsa-miR-3692	CLIP-seq
MIRT1961536	hsa-miR-3913-5p	CLIP-seq
MIRT1961537	hsa-miR-3936	CLIP-seq
MIRT1961538	hsa-miR-4425	CLIP-seq
MIRT1961539	hsa-miR-4455	CLIP-seq
MIRT1961540	hsa-miR-4506	CLIP-seq
MIRT1961541	hsa-miR-4533	CLIP-seq
MIRT1961542	hsa-miR-4652-5p	CLIP-seq
MIRT1961543	hsa-miR-4661-3p	CLIP-seq
MIRT1961544	hsa-miR-4685-5p	CLIP-seq
MIRT1961545	hsa-miR-4694-5p	CLIP-seq
MIRT1961546	hsa-miR-4738-3p	CLIP-seq
MIRT1961547	hsa-miR-4747-5p	CLIP-seq
MIRT1961548	hsa-miR-4776-5p	CLIP-seq
MIRT1961549	hsa-miR-4779	CLIP-seq
MIRT1961550	hsa-miR-580	CLIP-seq
MIRT1961551	hsa-miR-609	CLIP-seq
MIRT1961552	hsa-miR-665	CLIP-seq
MIRT1961553	hsa-miR-888	CLIP-seq
MIRT1961554	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IDA	9395522
GO:0001533	Component	Cornified envelope	TAS
GO:0003336	Process	Corneocyte desquamation	IMP	26014679
GO:0005576	Component	Extracellular region	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005911	Component	Cell-cell junction	TAS	9395522
GO:0007155	Process	Cell adhesion	TAS	9395522
GO:0008544	Process	Epidermis development	TAS	9395522
GO:0030057	Component	Desmosome	IDA	11279026, 26014679
GO:0030057	Component	Desmosome	NAS	9395522
GO:0030216	Process	Keratinocyte differentiation	NAS	8415725
GO:0042803	Function	Protein homodimerization activity	IBA	21873635
GO:0042803	Function	Protein homodimerization activity	IDA	15086562
GO:0043589	Process	Skin morphogenesis	IMP	20691404, 26014679
GO:0070268	Process	Cornification	TAS
GO:0098609	Process	Cell-cell adhesion	IBA	21873635
GO:0098609	Process	Cell-cell adhesion	IDA	11739386
GO:1905716	Process	Negative regulation of cornification	IMP	26014679

Other IDs

• MIM: 602593
• HGNC: 1802
• e!Ensembl: ENSG00000204539

Protein

• UniProt ID: Q15517
• Protein name: Corneodesmosin (S protein)
• Protein function: Important for the epidermal barrier integrity.
• Sequence:

  MGSSRAPWMGRVGGHGMMALLLAGLLLPGTLAKSIGTFSDPCKDPTRITSPNDPCLTGKG
  DSSGFSSYSGSSSSGSSISSARSSGGGSSGSSSGSSIAQGGSAGSFKPGTGYSQVSYSSG
  SGSSLQGASGSSQLGSSSSHSGNSGSHSGSSSSHSSSSSSFQFSSSSFQVGNGSALPTND
  NSYRGILNPSQPGQSSSSSQTSGVSSSGQSVSSNQRPCSSDIPDSPCSGGPIVSHSGPYI
  PSSHSVSGGQRPVVVVVDQHGSGAPGVVQGPPCSNGGLPGKPCPPITSVDKSYGGYEVVG
  GSSDSYLVPGMTYSKGKIYPVGYFTKENPVKGSPGVPSFAAGPPISEGKYFSSNPIIPSQ
  SAASSAIAFQPVGTGGVQLCGGGSTGSKGPCSPSSSRVPSSSSISSSSGSPYHPCGSASQ
  SPCSPPGTGSFSSSSSSQSSGKIILQPCGSKSSSSGHPCMSVSSLTLTGGPDGSPHPDPS
  AGAKPCGSSSAGKIPCRSIRDILAQVKPLGPQLADPEVFLPQGELLDSP

• Sequence length: 529

Pathways

Reactome:

Formation of the cornified envelope

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	27611488
Behcet syndrome	Behcet Syndrome	rs886040969, rs886039866, rs746055479, rs752615209, rs774164456, rs751454741	23001997
Hypotrichosis simplex	Hypotrichosis Simplex of Scalp	rs121913026, rs201249971	12754508, 22875505
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	17660530
Peeling skin syndrome	PEELING SKIN SYNDROME, Peeling skin syndrome type B	rs398122804, rs387906689, rs387906841, rs672601343, rs606231275, rs606231277, rs747711488, rs149474339, rs374612640, rs1050823116, rs1553219199, rs1246486951, rs755087362	20691404, 23957618
Rheumatoid arthritis	Rheumatoid Arthritis	rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212	19503088

Unknown
Disease name	Disease term	dbSNP ID	References
Dwarfism	Dwarfism
Graves disease	Graves Disease		21900946
Hypotrichosis simplex of the scalp	Hypotrichosis simplex of the scalp
Onycholysis	Onycholysis
Oral ulcer	Oral Ulcer		30837455