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BTN3A3 (butyrophilin subfamily 3 member A3)

Gene

10384

Butyrophilin subfamily 3 member A3

BTN3A3

BTF3, BTN3.3

6p22.2

The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of hum

Show/Hide all(204)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018863	hsa-miR-335-5p	Microarray	18185580
MIRT020447	hsa-miR-106b-5p	Microarray	17242205
MIRT030012	hsa-miR-26b-5p	Microarray	19088304
MIRT039804	hsa-miR-615-3p	CLASH	23622248
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT559162	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT559161	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT559160	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT559159	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT559158	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT559157	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT559156	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT559155	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT559154	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT559153	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT559152	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT559151	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT559150	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT559149	hsa-miR-646	PAR-CLIP	21572407
MIRT559147	hsa-miR-4274	PAR-CLIP	21572407
MIRT559148	hsa-miR-3163	PAR-CLIP	21572407
MIRT559146	hsa-miR-5692b	PAR-CLIP	21572407
MIRT559145	hsa-miR-5692c	PAR-CLIP	21572407
MIRT559144	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT559143	hsa-miR-302a-5p	PAR-CLIP	21572407
MIRT559142	hsa-miR-4660	PAR-CLIP	21572407
MIRT559141	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT559140	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT020447	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT441094	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441093	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT020447	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT728175	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT728174	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT728172	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT728173	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT441094	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT441093	hsa-miR-21-5p	HITS-CLIP	22473208
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT572227	hsa-miR-219a-2-3p	PAR-CLIP	20371350
MIRT572226	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT572225	hsa-miR-548p	PAR-CLIP	20371350
MIRT572224	hsa-miR-22-3p	PAR-CLIP	20371350
MIRT572223	hsa-miR-219b-3p	PAR-CLIP	20371350
MIRT572222	hsa-miR-223-5p	PAR-CLIP	20371350
MIRT572221	hsa-miR-518a-5p	PAR-CLIP	20371350
MIRT572220	hsa-miR-527	PAR-CLIP	20371350
MIRT572219	hsa-miR-568	PAR-CLIP	20371350
MIRT559162	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT559161	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT559160	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT559159	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT559158	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT559157	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT559156	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT559155	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT559154	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT559153	hsa-miR-3606-3p	PAR-CLIP	21572407
MIRT559152	hsa-miR-513a-3p	PAR-CLIP	21572407
MIRT559151	hsa-miR-513c-3p	PAR-CLIP	21572407
MIRT559150	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT559149	hsa-miR-646	PAR-CLIP	21572407
MIRT559147	hsa-miR-4274	PAR-CLIP	21572407
MIRT559148	hsa-miR-3163	PAR-CLIP	21572407
MIRT559146	hsa-miR-5692b	PAR-CLIP	21572407
MIRT559145	hsa-miR-5692c	PAR-CLIP	21572407
MIRT559144	hsa-miR-6736-3p	PAR-CLIP	21572407
MIRT559143	hsa-miR-302a-5p	PAR-CLIP	21572407
MIRT559142	hsa-miR-4660	PAR-CLIP	21572407
MIRT559141	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT559140	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT827465	hsa-miR-3189-5p	CLIP-seq
MIRT827466	hsa-miR-4514	CLIP-seq
MIRT827467	hsa-miR-4690-5p	CLIP-seq
MIRT827468	hsa-miR-4692	CLIP-seq
MIRT827469	hsa-miR-4758-3p	CLIP-seq
MIRT827470	hsa-miR-488	CLIP-seq
MIRT827471	hsa-miR-595	CLIP-seq
MIRT827472	hsa-miR-644	CLIP-seq
MIRT827473	hsa-miR-663b	CLIP-seq
MIRT827474	hsa-miR-3148	CLIP-seq
MIRT827475	hsa-miR-3153	CLIP-seq
MIRT827476	hsa-miR-3155	CLIP-seq
MIRT827477	hsa-miR-3155b	CLIP-seq
MIRT827478	hsa-miR-3652	CLIP-seq
MIRT827479	hsa-miR-4430	CLIP-seq
MIRT827480	hsa-miR-4648	CLIP-seq
MIRT827481	hsa-miR-4654	CLIP-seq
MIRT827482	hsa-miR-4668-5p	CLIP-seq
MIRT827483	hsa-miR-4769-5p	CLIP-seq
MIRT827484	hsa-miR-484	CLIP-seq
MIRT827485	hsa-miR-548c-3p	CLIP-seq
MIRT2183337	hsa-miR-1262	CLIP-seq
MIRT2183338	hsa-miR-1292	CLIP-seq
MIRT2183339	hsa-miR-1293	CLIP-seq
MIRT2183340	hsa-miR-3074-3p	CLIP-seq
MIRT2183341	hsa-miR-3147	CLIP-seq
MIRT2183342	hsa-miR-4425	CLIP-seq
MIRT2183343	hsa-miR-4471	CLIP-seq
MIRT2183344	hsa-miR-4483	CLIP-seq
MIRT2183345	hsa-miR-4701-3p	CLIP-seq
MIRT827466	hsa-miR-4514	CLIP-seq
MIRT827467	hsa-miR-4690-5p	CLIP-seq
MIRT827468	hsa-miR-4692	CLIP-seq
MIRT2676157	hsa-miR-1245	CLIP-seq
MIRT2676158	hsa-miR-1251	CLIP-seq
MIRT2676159	hsa-miR-1252	CLIP-seq
MIRT2676160	hsa-miR-1254	CLIP-seq
MIRT2676161	hsa-miR-137	CLIP-seq
MIRT2676162	hsa-miR-150	CLIP-seq
MIRT2676163	hsa-miR-2053	CLIP-seq
MIRT2676164	hsa-miR-21	CLIP-seq
MIRT2676165	hsa-miR-216b	CLIP-seq
MIRT2183340	hsa-miR-3074-3p	CLIP-seq
MIRT2676166	hsa-miR-3116	CLIP-seq
MIRT2676167	hsa-miR-3123	CLIP-seq
MIRT2676168	hsa-miR-3130-3p	CLIP-seq
MIRT2676169	hsa-miR-3150b-3p	CLIP-seq
MIRT2676170	hsa-miR-3194-3p	CLIP-seq
MIRT2676171	hsa-miR-337-3p	CLIP-seq
MIRT2676172	hsa-miR-339-5p	CLIP-seq
MIRT2676173	hsa-miR-3614-5p	CLIP-seq
MIRT2676174	hsa-miR-3618	CLIP-seq
MIRT2676175	hsa-miR-3675-3p	CLIP-seq
MIRT2676176	hsa-miR-3682-3p	CLIP-seq
MIRT2676177	hsa-miR-3685	CLIP-seq
MIRT2676178	hsa-miR-384	CLIP-seq
MIRT2676179	hsa-miR-3913-3p	CLIP-seq
MIRT2676180	hsa-miR-3919	CLIP-seq
MIRT2676181	hsa-miR-3929	CLIP-seq
MIRT2676182	hsa-miR-3942-5p	CLIP-seq
MIRT2676183	hsa-miR-409-3p	CLIP-seq
MIRT2676184	hsa-miR-4261	CLIP-seq
MIRT2676185	hsa-miR-4267	CLIP-seq
MIRT2676186	hsa-miR-4328	CLIP-seq
MIRT2676187	hsa-miR-4419b	CLIP-seq
MIRT2676188	hsa-miR-4446-5p	CLIP-seq
MIRT2676189	hsa-miR-4476	CLIP-seq
MIRT2676190	hsa-miR-4478	CLIP-seq
MIRT2676191	hsa-miR-4480	CLIP-seq
MIRT2676192	hsa-miR-4511	CLIP-seq
MIRT827481	hsa-miR-4654	CLIP-seq
MIRT2676193	hsa-miR-4689	CLIP-seq
MIRT827467	hsa-miR-4690-5p	CLIP-seq
MIRT2676194	hsa-miR-4693-5p	CLIP-seq
MIRT2676195	hsa-miR-4703-5p	CLIP-seq
MIRT2676196	hsa-miR-4710	CLIP-seq
MIRT2676197	hsa-miR-4713-5p	CLIP-seq
MIRT2676198	hsa-miR-4719	CLIP-seq
MIRT2676199	hsa-miR-4727-3p	CLIP-seq
MIRT2676200	hsa-miR-4755-5p	CLIP-seq
MIRT2676201	hsa-miR-4760-3p	CLIP-seq
MIRT2676202	hsa-miR-4760-5p	CLIP-seq
MIRT827483	hsa-miR-4769-5p	CLIP-seq
MIRT2676203	hsa-miR-4784	CLIP-seq
MIRT2676204	hsa-miR-4792	CLIP-seq
MIRT2676205	hsa-miR-4793-3p	CLIP-seq
MIRT2676206	hsa-miR-489	CLIP-seq
MIRT2676207	hsa-miR-502-5p	CLIP-seq
MIRT2676208	hsa-miR-516a-3p	CLIP-seq
MIRT2676209	hsa-miR-532-3p	CLIP-seq
MIRT2676210	hsa-miR-544	CLIP-seq
MIRT2676211	hsa-miR-548ac	CLIP-seq
MIRT2676212	hsa-miR-548ae	CLIP-seq
MIRT2676213	hsa-miR-548aj	CLIP-seq
MIRT2676214	hsa-miR-548am	CLIP-seq
MIRT2676215	hsa-miR-548b-3p	CLIP-seq
MIRT2676216	hsa-miR-548d-3p	CLIP-seq
MIRT2676217	hsa-miR-548x	CLIP-seq
MIRT2676218	hsa-miR-548z	CLIP-seq
MIRT2676219	hsa-miR-549	CLIP-seq
MIRT2676220	hsa-miR-561	CLIP-seq
MIRT2676221	hsa-miR-569	CLIP-seq
MIRT2676222	hsa-miR-590-5p	CLIP-seq
MIRT2676223	hsa-miR-633	CLIP-seq
MIRT2676224	hsa-miR-640	CLIP-seq
MIRT2676225	hsa-miR-661	CLIP-seq
MIRT2676226	hsa-miR-875-3p	CLIP-seq
MIRT2676227	hsa-miR-934	CLIP-seq

Show/Hide all(9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001817	Process	Regulation of cytokine production	IBA	21873635
GO:0002456	Process	T cell mediated immunity	IMP	22767497
GO:0005102	Function	Signaling receptor binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	22767497
GO:0005886	Component	Plasma membrane	TAS
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0050852	Process	T cell receptor signaling pathway	IBA	21873635

MIM	HGNC	e!Ensembl
613595	1140	ENSG00000111801

Protein

UniProt ID

O00478

Protein name

Butyrophilin subfamily 3 member A3

Protein function

Plays a role in T-cell responses in the adaptive immune response.

PDB

4F8T , 5ZZ3 , 6J0G , 6J0K , 6J0L

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07686	V-set	35 → 144	Immunoglobulin V-set domain	Domain
PF13765	PRY	342 → 390	SPRY-associated domain	Family
PF00622	SPRY	394 → 506	SPRY domain	Family

Sequence

MKMASSLAFLLLNFHVSLFLVQLLTPCSAQFSVLGPSGPILAMVGEDADLPCHLFPTMSA
ETMELRWVSSSLRQVVNVYADGKEVEDRQSAPYRGRTSILRDGITAGKAALRIHNVTASD
SGKYLCYFQDGDFYEKALVELKVAALGSDLHIEVKGYEDGGIHLECRSTGWYPQPQIKWS
DTKGENIPAVEAPVVADGVGLYAVAASVIMRGSSGGGVSCIIRNSLLGLEKTASISIADP
FFRSAQPWIAALAGTLPISLLLLAGASYFLWRQQKEKIALSRETEREREMKEMGYAATEQ
EISLREKLQEELKWRKIQYMARGEKSLAYHEWKMALFKPADVILDPDTANAILLVSEDQR
SVQRAEEPRDLPDNPERFEWRYCVLGCENFTSGRHYWEVEVGDRKEWHIGVCSKNVERKK
GWVKMTPENGYWTMGLTDGNKYRALTEPRTNLKLPEPPRKVGIFLDYETGEISFYNATDG
SHIYTFPHASFSEPLYPVFRILTLEPTALTICPIPKEVESSPDPDLVPDHSLETPLTPGL
ANESGEPQAEVTSLLLPAHPGAEVSPSATTNQNHKLQARTEALY

Sequence length

584

Interactions

View interactions

	Reactome
			Butyrophilin (BTN) family interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Squamous cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	21971053

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