TLR6 (toll like receptor 6)

Gene

• Entrez ID: 10333
• Gene name: Toll like receptor 6
• Gene symbol: TLR6
• Synonyms: CD286
• Chromosome: 4
• Chromosome location: 4p14
• Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and func

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT679765	hsa-miR-1245a	HITS-CLIP	23824327
MIRT679764	hsa-miR-8079	HITS-CLIP	23824327
MIRT679763	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT679762	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679761	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679760	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679759	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679758	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679757	hsa-miR-6131	HITS-CLIP	23824327
MIRT679756	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679755	hsa-miR-640	HITS-CLIP	23824327
MIRT679754	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679753	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT652575	hsa-miR-7153-3p	HITS-CLIP	23824327
MIRT652574	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT652573	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT652572	hsa-miR-3185	HITS-CLIP	23824327
MIRT652571	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT652570	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT652569	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT652568	hsa-miR-23c	HITS-CLIP	23824327
MIRT652567	hsa-miR-3611	HITS-CLIP	23824327
MIRT652565	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT679765	hsa-miR-1245a	HITS-CLIP	23824327
MIRT679764	hsa-miR-8079	HITS-CLIP	23824327
MIRT679763	hsa-miR-6513-3p	HITS-CLIP	23824327
MIRT679762	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT679761	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT679760	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT679759	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT679758	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT679757	hsa-miR-6131	HITS-CLIP	23824327
MIRT679756	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT679755	hsa-miR-640	HITS-CLIP	23824327
MIRT679754	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT679753	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT652575	hsa-miR-7153-3p	HITS-CLIP	23824327
MIRT652574	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT652573	hsa-miR-95-5p	HITS-CLIP	23824327
MIRT652572	hsa-miR-3185	HITS-CLIP	23824327
MIRT652571	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT652570	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT652569	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT652568	hsa-miR-23c	HITS-CLIP	23824327
MIRT652567	hsa-miR-3611	HITS-CLIP	23824327
MIRT652565	hsa-miR-2681-5p	HITS-CLIP	23824327
MIRT1426977	hsa-miR-1245	CLIP-seq
MIRT1426978	hsa-miR-1262	CLIP-seq
MIRT1426979	hsa-miR-1278	CLIP-seq
MIRT1426980	hsa-miR-1280	CLIP-seq
MIRT1426981	hsa-miR-1294	CLIP-seq
MIRT1426982	hsa-miR-1324	CLIP-seq
MIRT1426983	hsa-miR-149	CLIP-seq
MIRT1426984	hsa-miR-15a	CLIP-seq
MIRT1426985	hsa-miR-15b	CLIP-seq
MIRT1426986	hsa-miR-16	CLIP-seq
MIRT1426987	hsa-miR-195	CLIP-seq
MIRT1426988	hsa-miR-197	CLIP-seq
MIRT1426989	hsa-miR-3064-5p	CLIP-seq
MIRT1426990	hsa-miR-3065-3p	CLIP-seq
MIRT1426991	hsa-miR-3126-3p	CLIP-seq
MIRT1426992	hsa-miR-3169	CLIP-seq
MIRT1426993	hsa-miR-3187-3p	CLIP-seq
MIRT1426994	hsa-miR-3907	CLIP-seq
MIRT1426995	hsa-miR-3914	CLIP-seq
MIRT1426996	hsa-miR-3915	CLIP-seq
MIRT1426997	hsa-miR-3928	CLIP-seq
MIRT1426998	hsa-miR-424	CLIP-seq
MIRT1426999	hsa-miR-4316	CLIP-seq
MIRT1427000	hsa-miR-4435	CLIP-seq
MIRT1427001	hsa-miR-4677-3p	CLIP-seq
MIRT1427002	hsa-miR-4701-3p	CLIP-seq
MIRT1427003	hsa-miR-4701-5p	CLIP-seq
MIRT1427004	hsa-miR-4716-5p	CLIP-seq
MIRT1427005	hsa-miR-4781-3p	CLIP-seq
MIRT1427006	hsa-miR-4794	CLIP-seq
MIRT1427007	hsa-miR-497	CLIP-seq
MIRT1427008	hsa-miR-5096	CLIP-seq
MIRT1427009	hsa-miR-548s	CLIP-seq
MIRT1427010	hsa-miR-576-3p	CLIP-seq
MIRT1427011	hsa-miR-588	CLIP-seq
MIRT1427012	hsa-miR-765	CLIP-seq
MIRT1426977	hsa-miR-1245	CLIP-seq
MIRT1426977	hsa-miR-1245	CLIP-seq
MIRT1426988	hsa-miR-197	CLIP-seq
MIRT1426993	hsa-miR-3187-3p	CLIP-seq
MIRT1427000	hsa-miR-4435	CLIP-seq
MIRT1427003	hsa-miR-4701-5p	CLIP-seq
MIRT1427004	hsa-miR-4716-5p	CLIP-seq
MIRT1427005	hsa-miR-4781-3p	CLIP-seq
MIRT1427008	hsa-miR-5096	CLIP-seq
MIRT1427009	hsa-miR-548s	CLIP-seq
MIRT1427011	hsa-miR-588	CLIP-seq
MIRT2127909	hsa-miR-1207-5p	CLIP-seq
MIRT1426977	hsa-miR-1245	CLIP-seq
MIRT2127910	hsa-miR-1322	CLIP-seq
MIRT2127911	hsa-miR-1827	CLIP-seq
MIRT1426988	hsa-miR-197	CLIP-seq
MIRT2127912	hsa-miR-198	CLIP-seq
MIRT2127913	hsa-miR-3065-5p	CLIP-seq
MIRT2127914	hsa-miR-3074-5p	CLIP-seq
MIRT2127915	hsa-miR-3158-3p	CLIP-seq
MIRT2127916	hsa-miR-3175	CLIP-seq
MIRT2127917	hsa-miR-3199	CLIP-seq
MIRT2127918	hsa-miR-4515	CLIP-seq
MIRT1427004	hsa-miR-4716-5p	CLIP-seq
MIRT2127919	hsa-miR-4721	CLIP-seq
MIRT2127920	hsa-miR-4722-3p	CLIP-seq
MIRT2127921	hsa-miR-4735-5p	CLIP-seq
MIRT2127922	hsa-miR-4740-3p	CLIP-seq
MIRT2127923	hsa-miR-4763-3p	CLIP-seq
MIRT2127924	hsa-miR-4775	CLIP-seq
MIRT1427005	hsa-miR-4781-3p	CLIP-seq
MIRT1427008	hsa-miR-5096	CLIP-seq
MIRT2127925	hsa-miR-552	CLIP-seq
MIRT2127926	hsa-miR-590-3p	CLIP-seq
MIRT2127927	hsa-miR-764	CLIP-seq
MIRT2127928	hsa-miR-940	CLIP-seq
MIRT2127909	hsa-miR-1207-5p	CLIP-seq
MIRT1426977	hsa-miR-1245	CLIP-seq
MIRT1426982	hsa-miR-1324	CLIP-seq
MIRT2127911	hsa-miR-1827	CLIP-seq
MIRT2127914	hsa-miR-3074-5p	CLIP-seq
MIRT2349556	hsa-miR-3150a-3p	CLIP-seq
MIRT2127916	hsa-miR-3175	CLIP-seq
MIRT2127917	hsa-miR-3199	CLIP-seq
MIRT2349557	hsa-miR-3943	CLIP-seq
MIRT2349558	hsa-miR-4323	CLIP-seq
MIRT2349559	hsa-miR-4632	CLIP-seq
MIRT2349560	hsa-miR-4667-5p	CLIP-seq
MIRT2349561	hsa-miR-4700-5p	CLIP-seq
MIRT2127920	hsa-miR-4722-3p	CLIP-seq
MIRT2127921	hsa-miR-4735-5p	CLIP-seq
MIRT2127922	hsa-miR-4740-3p	CLIP-seq
MIRT2127923	hsa-miR-4763-3p	CLIP-seq
MIRT2127924	hsa-miR-4775	CLIP-seq
MIRT2349562	hsa-miR-532-3p	CLIP-seq
MIRT2127925	hsa-miR-552	CLIP-seq
MIRT2127926	hsa-miR-590-3p	CLIP-seq
MIRT2349563	hsa-miR-593	CLIP-seq
MIRT2127927	hsa-miR-764	CLIP-seq
MIRT2349564	hsa-miR-939	CLIP-seq
MIRT2127928	hsa-miR-940	CLIP-seq
MIRT2349565	hsa-miR-941	CLIP-seq
MIRT2395862	hsa-miR-1267	CLIP-seq
MIRT2395863	hsa-miR-2355-5p	CLIP-seq
MIRT2395864	hsa-miR-4279	CLIP-seq
MIRT2395865	hsa-miR-4652-3p	CLIP-seq
MIRT2461510	hsa-miR-1253	CLIP-seq
MIRT2461511	hsa-miR-185	CLIP-seq
MIRT2461512	hsa-miR-3150b-3p	CLIP-seq
MIRT2127917	hsa-miR-3199	CLIP-seq
MIRT2461513	hsa-miR-4306	CLIP-seq
MIRT2461514	hsa-miR-4644	CLIP-seq
MIRT2461515	hsa-miR-4784	CLIP-seq
MIRT2127925	hsa-miR-552	CLIP-seq
MIRT2127927	hsa-miR-764	CLIP-seq
MIRT2349565	hsa-miR-941	CLIP-seq
MIRT2643084	hsa-miR-1297	CLIP-seq
MIRT2643085	hsa-miR-150	CLIP-seq
MIRT2643086	hsa-miR-1915	CLIP-seq
MIRT2643087	hsa-miR-26a	CLIP-seq
MIRT2643088	hsa-miR-26b	CLIP-seq
MIRT2643089	hsa-miR-3120-5p	CLIP-seq
MIRT2643090	hsa-miR-3149	CLIP-seq
MIRT2643091	hsa-miR-4465	CLIP-seq
MIRT2643092	hsa-miR-4713-5p	CLIP-seq
MIRT2643093	hsa-miR-4726-3p	CLIP-seq
MIRT2127921	hsa-miR-4735-5p	CLIP-seq
MIRT2127924	hsa-miR-4775	CLIP-seq
MIRT2349562	hsa-miR-532-3p	CLIP-seq
MIRT2127926	hsa-miR-590-3p	CLIP-seq
MIRT2349565	hsa-miR-941	CLIP-seq
MIRT2643084	hsa-miR-1297	CLIP-seq
MIRT2643085	hsa-miR-150	CLIP-seq
MIRT2643086	hsa-miR-1915	CLIP-seq
MIRT2643087	hsa-miR-26a	CLIP-seq
MIRT2643088	hsa-miR-26b	CLIP-seq
MIRT2643089	hsa-miR-3120-5p	CLIP-seq
MIRT2693223	hsa-miR-3122	CLIP-seq
MIRT2643090	hsa-miR-3149	CLIP-seq
MIRT2693224	hsa-miR-3190	CLIP-seq
MIRT2127917	hsa-miR-3199	CLIP-seq
MIRT2693225	hsa-miR-3913-5p	CLIP-seq
MIRT2643091	hsa-miR-4465	CLIP-seq
MIRT2693226	hsa-miR-450b-3p	CLIP-seq
MIRT2693227	hsa-miR-455-5p	CLIP-seq
MIRT2643092	hsa-miR-4713-5p	CLIP-seq
MIRT2643093	hsa-miR-4726-3p	CLIP-seq
MIRT2127921	hsa-miR-4735-5p	CLIP-seq
MIRT2693228	hsa-miR-4752	CLIP-seq
MIRT2127924	hsa-miR-4775	CLIP-seq
MIRT2349562	hsa-miR-532-3p	CLIP-seq
MIRT2127925	hsa-miR-552	CLIP-seq
MIRT2127926	hsa-miR-590-3p	CLIP-seq
MIRT2693229	hsa-miR-7	CLIP-seq
MIRT2127927	hsa-miR-764	CLIP-seq
MIRT2693230	hsa-miR-769-3p	CLIP-seq
MIRT2349565	hsa-miR-941	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HIF1A	Unknown	18159247

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001540	Function	Amyloid-beta binding	IC	20037584
GO:0001774	Process	Microglial cell activation	IEA
GO:0001775	Process	Cell activation	IDA	15294986
GO:0002224	Process	Toll-like receptor signaling pathway	IBA	21873635
GO:0002224	Process	Toll-like receptor signaling pathway	TAS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	ISS
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005102	Function	Signaling receptor binding	IPI	20037584
GO:0005515	Function	Protein binding	IPI	16880211, 20037584, 20067962, 23155421
GO:0005794	Component	Golgi apparatus	IDA	16880211
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0006954	Process	Inflammatory response	IBA	21873635
GO:0006955	Process	Immune response	TAS	10426995
GO:0007165	Process	Signal transduction	TAS	10231569
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	NAS	10231569
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0032611	Process	Interleukin-1 beta production	ISS
GO:0032717	Process	Negative regulation of interleukin-8 production	IGI	22198949
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS	12077222
GO:0034136	Process	Negative regulation of toll-like receptor 2 signaling pathway	IGI	22198949
GO:0034150	Process	Toll-like receptor 6 signaling pathway	IEA
GO:0035355	Component	Toll-like receptor 2-Toll-like receptor 6 protein complex	IBA	21873635
GO:0035663	Function	Toll-like receptor 2 binding	IBA	21873635
GO:0035663	Function	Toll-like receptor 2 binding	IPI	16880211
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	ISS
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0038124	Process	Toll-like receptor TLR6:TLR2 signaling pathway	TAS
GO:0042496	Process	Detection of diacyl bacterial lipopeptide	IDA	19931471
GO:0042742	Process	Defense response to bacterium	TAS	10426995
GO:0042802	Function	Identical protein binding	IDA	25088687
GO:0042802	Function	Identical protein binding	IPI	23155421
GO:0043032	Process	Positive regulation of macrophage activation	ISS
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	10231569
GO:0043235	Component	Receptor complex	IPI	20037584
GO:0043507	Process	Positive regulation of JUN kinase activity	IDA	10231569
GO:0045087	Process	Innate immune response	IEA
GO:0045121	Component	Membrane raft	IDA	16880211
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	ISS
GO:0046209	Process	Nitric oxide metabolic process	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	20037584
GO:0050135	Function	NAD(P)+ nucleosidase activity	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IGI	20037584
GO:0061809	Function	NAD+ nucleotidase, cyclic ADP-ribose generating	IEA
GO:0071221	Process	Cellular response to bacterial lipopeptide	IBA	21873635
GO:0071723	Function	Lipopeptide binding	IBA	21873635
GO:0071723	Function	Lipopeptide binding	ISS	11431423
GO:0071726	Process	Cellular response to diacyl bacterial lipopeptide	IBA	21873635
GO:0071726	Process	Cellular response to diacyl bacterial lipopeptide	IDA	16880211, 19931471
GO:0140052	Process	Cellular response to oxidised low-density lipoprotein particle stimulus	ISS
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	ISS
GO:1900227	Process	Positive regulation of NLRP3 inflammasome complex assembly	ISS
GO:1903223	Process	Positive regulation of oxidative stress-induced neuron death	ISS
GO:1903428	Process	Positive regulation of reactive oxygen species biosynthetic process	ISS
GO:1904646	Process	Cellular response to amyloid-beta	IGI	20037584

Other IDs

• MIM: 605403
• HGNC: 16711
• e!Ensembl: ENSG00000174130

Protein

• UniProt ID: Q9Y2C9
• Protein name: Toll-like receptor 6 (CD antigen CD286)
• Protein function: Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation
• PDB: 4OM7
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13855	LRR_8	76 → 133	Leucine rich repeat	Repeat
  PF13855	LRR_8	450 → 507	Leucine rich repeat	Repeat
  PF01463	LRRCT	558 → 583	Leucine rich repeat C-terminal domain	Family
  PF01582	TIR	641 → 796	TIR domain	Family

• Sequence:

  MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMS
  QNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI
  VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN
  YYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIK
  FLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS
  KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF
  TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRH
  KENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNV
  AFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREF
  VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAV
  TVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSEL
  VPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH
  HNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA
  FNMKLTLVTENNDVKS

• Sequence length: 796

Pathways

KEGG:

Phagosome
Toll-like receptor signaling pathway
Salmonella infection
Chagas disease
Tuberculosis
Lipid and atherosclerosis

Reactome:

ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	29785011
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	16537705

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		16537705