SIRPB1 (signal regulatory protein beta 1)

Gene

• Entrez ID: 10326
• Gene name: Signal regulatory protein beta 1
• Gene symbol: SIRPB1
• Synonyms: CD172b, SIRB1, SIRP-BETA-1
• Chromosome: 20
• Chromosome location: 20p13
• Summary: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulat

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT739081	hsa-miR-942	HITS-CLIP	33718276
MIRT1349936	hsa-miR-1245b-3p	CLIP-seq
MIRT1349937	hsa-miR-1252	CLIP-seq
MIRT1349938	hsa-miR-1293	CLIP-seq
MIRT1349939	hsa-miR-1302	CLIP-seq
MIRT1349940	hsa-miR-1321	CLIP-seq
MIRT1349941	hsa-miR-1827	CLIP-seq
MIRT1349942	hsa-miR-3165	CLIP-seq
MIRT1349943	hsa-miR-3173-3p	CLIP-seq
MIRT1349944	hsa-miR-3192	CLIP-seq
MIRT1349945	hsa-miR-3612	CLIP-seq
MIRT1349946	hsa-miR-3646	CLIP-seq
MIRT1349947	hsa-miR-3661	CLIP-seq
MIRT1349948	hsa-miR-3662	CLIP-seq
MIRT1349949	hsa-miR-3689d	CLIP-seq
MIRT1349950	hsa-miR-4270	CLIP-seq
MIRT1349951	hsa-miR-4282	CLIP-seq
MIRT1349952	hsa-miR-4298	CLIP-seq
MIRT1349953	hsa-miR-4318	CLIP-seq
MIRT1349954	hsa-miR-4419a	CLIP-seq
MIRT1349955	hsa-miR-4441	CLIP-seq
MIRT1349956	hsa-miR-4474-3p	CLIP-seq
MIRT1349957	hsa-miR-4483	CLIP-seq
MIRT1349958	hsa-miR-4499	CLIP-seq
MIRT1349959	hsa-miR-4510	CLIP-seq
MIRT1349960	hsa-miR-4514	CLIP-seq
MIRT1349961	hsa-miR-4635	CLIP-seq
MIRT1349962	hsa-miR-4651	CLIP-seq
MIRT1349963	hsa-miR-4692	CLIP-seq
MIRT1349964	hsa-miR-4695-5p	CLIP-seq
MIRT1349965	hsa-miR-4728-5p	CLIP-seq
MIRT1349966	hsa-miR-4739	CLIP-seq
MIRT1349967	hsa-miR-4756-5p	CLIP-seq
MIRT1349968	hsa-miR-4779	CLIP-seq
MIRT1349969	hsa-miR-608	CLIP-seq
MIRT1349970	hsa-miR-631	CLIP-seq
MIRT1349971	hsa-miR-650	CLIP-seq
MIRT1349972	hsa-miR-765	CLIP-seq
MIRT1349973	hsa-miR-922	CLIP-seq
MIRT1349974	hsa-miR-1207-5p	CLIP-seq
MIRT739083	hsa-miR-1226	CLIP-seq
MIRT739085	hsa-miR-1229	CLIP-seq
MIRT1349975	hsa-miR-1343	CLIP-seq
MIRT1349976	hsa-miR-1909	CLIP-seq
MIRT1349977	hsa-miR-3074-5p	CLIP-seq
MIRT739082	hsa-miR-3127-3p	CLIP-seq
MIRT1349944	hsa-miR-3192	CLIP-seq
MIRT1349978	hsa-miR-3613-5p	CLIP-seq
MIRT1349979	hsa-miR-3688-5p	CLIP-seq
MIRT1349980	hsa-miR-3689a-3p	CLIP-seq
MIRT1349981	hsa-miR-3689c	CLIP-seq
MIRT1349949	hsa-miR-3689d	CLIP-seq
MIRT1349982	hsa-miR-4687-3p	CLIP-seq
MIRT1349983	hsa-miR-4716-5p	CLIP-seq
MIRT1349965	hsa-miR-4728-5p	CLIP-seq
MIRT739084	hsa-miR-4733-3p	CLIP-seq
MIRT1349984	hsa-miR-4736	CLIP-seq
MIRT1349985	hsa-miR-4747-5p	CLIP-seq
MIRT1349986	hsa-miR-4763-3p	CLIP-seq
MIRT739080	hsa-miR-4768-5p	CLIP-seq
MIRT1349968	hsa-miR-4779	CLIP-seq
MIRT1349987	hsa-miR-485-5p	CLIP-seq
MIRT1349988	hsa-miR-630	CLIP-seq
MIRT1349972	hsa-miR-765	CLIP-seq
MIRT1349983	hsa-miR-4716-5p	CLIP-seq
MIRT1349974	hsa-miR-1207-5p	CLIP-seq
MIRT1349976	hsa-miR-1909	CLIP-seq
MIRT1349979	hsa-miR-3688-5p	CLIP-seq
MIRT1349983	hsa-miR-4716-5p	CLIP-seq
MIRT1349984	hsa-miR-4736	CLIP-seq
MIRT1349986	hsa-miR-4763-3p	CLIP-seq
MIRT1349972	hsa-miR-765	CLIP-seq
MIRT1349974	hsa-miR-1207-5p	CLIP-seq
MIRT1349976	hsa-miR-1909	CLIP-seq
MIRT1349979	hsa-miR-3688-5p	CLIP-seq
MIRT1349983	hsa-miR-4716-5p	CLIP-seq
MIRT1349984	hsa-miR-4736	CLIP-seq
MIRT1349986	hsa-miR-4763-3p	CLIP-seq
MIRT1349972	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10940905
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	TAS	9062191
GO:0007165	Process	Signal transduction	TAS	9062191
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9062191
GO:0009986	Component	Cell surface	TAS	25795378
GO:0030667	Component	Secretory granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045087	Process	Innate immune response	TAS
GO:0050766	Process	Positive regulation of phagocytosis	IBA	21873635
GO:0050870	Process	Positive regulation of T cell activation	IBA	21873635

Other IDs

• MIM: 603889
• HGNC: 15928
• e!Ensembl: ENSG00000101307

Protein

• UniProt ID: O00241
• Protein name: Signal-regulatory protein beta-1 (SIRP-beta-1) (CD172 antigen-like family member B) (CD antigen CD172b)
• Protein function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Also participates in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associa
• PDB: 2D9C, 2JJU
• UniProt ID: Q5TFQ8
• Protein name: Signal-regulatory protein beta-1 isoform 3 (SIRP-beta-1 isoform 3)
• Protein function: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes.
• PDB: 2JJV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	37 → 144	Immunoglobulin V-set domain	Domain
  PF07654	C1-set	151 → 234	Immunoglobulin C1-set domain	Domain
  PF07654	C1-set	255 → 337	Immunoglobulin C1-set domain	Domain

• Sequence:

  MPVPASWPHLPSPFLLMTLLLGRLTGVAGEEELQVIQPDKSISVAAGESATLHCTVTSLI
  PVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISNITPADAGTYYC
  VKFRKGSPDHVEFKSGAGTELSVRAKPSAPVVSGPAARATPQHTVSFTCESHGFSPRDIT
  LKWFKNGNELSDFQTNVDPAGDSVSYSIHSTAKVVLTREDVHSQVICEVAHVTLQGDPLR
  GTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENGNVSRTETAST
  LTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTA
  PGPALASAAPLLIAFLLGPKVLLVVGVSVIYVYWKQKA

• Sequence length: 398

Pathways

KEGG:

Efferocytosis
Osteoclast differentiation

Reactome:

DAP12 interactions
Signal regulatory protein family interactions
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	24564241, 25039969