SNAPC5 (small nuclear RNA activating complex polypeptide 5)

Gene

• Entrez ID: 10302
• Gene name: Small nuclear RNA activating complex polypeptide 5
• Gene symbol: SNAPC5
• Synonyms: SNAP19
• Chromosome: 15
• Chromosome location: 15q22.31
• Summary: This gene encodes a subunit of the small nuclear RNA (snRNA)-activating protein complex that plays a role in the transcription of snRNA genes. This complex binds to the promoters of snRNA genes transcribed by either RNA polymerase II or III and recruits o

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029459	hsa-miR-26b-5p	Microarray	19088304
MIRT1375287	hsa-miR-1245b-3p	CLIP-seq
MIRT1375288	hsa-miR-197	CLIP-seq
MIRT1375289	hsa-miR-3140-3p	CLIP-seq
MIRT1375290	hsa-miR-3942-3p	CLIP-seq
MIRT1375291	hsa-miR-4315	CLIP-seq
MIRT1375292	hsa-miR-4659a-5p	CLIP-seq
MIRT1375293	hsa-miR-4659b-5p	CLIP-seq
MIRT1375294	hsa-miR-4776-3p	CLIP-seq
MIRT1375295	hsa-miR-4790-5p	CLIP-seq
MIRT1375296	hsa-miR-5096	CLIP-seq
MIRT1375297	hsa-miR-576-3p	CLIP-seq
MIRT1375298	hsa-miR-593	CLIP-seq
MIRT1375299	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000995	Function	RNA polymerase III general transcription initiation factor activity	IDA	9732265
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956
GO:0005634	Component	Nucleus	TAS	9732265
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0006384	Process	Transcription initiation from RNA polymerase III promoter	IEA
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IDA	9732265
GO:0016604	Component	Nuclear body	IDA
GO:0042795	Process	SnRNA transcription by RNA polymerase II	IDA	9732265
GO:0042795	Process	SnRNA transcription by RNA polymerase II	TAS
GO:0042796	Process	SnRNA transcription by RNA polymerase III	IDA	9732265

Other IDs

• MIM: 605979
• HGNC: 15484
• e!Ensembl: ENSG00000174446

Protein

• UniProt ID: O75971
• Protein name: snRNA-activating protein complex subunit 5 (SNAPc subunit 5) (Small nuclear RNA-activating complex polypeptide 5) (snRNA-activating protein complex 19 kDa subunit) (SNAPc 19 kDa subunit)
• Protein function: Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TB
• PDB: 7ZWC, 7ZWD, 7ZX7, 7ZX8, 7ZXE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15497	SNAPc19	7 → 97	snRNA-activating protein complex subunit 19, SNAPc subunit 19	Family

• Sequence:

  MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHD
  MLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS

• Sequence length: 98

Pathways

Reactome:

RNA polymerase II transcribes snRNA genes
RNA Polymerase III Transcription Initiation From Type 3 Promoter

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	22197931