DENND4A (DENN domain containing 4A)

Gene

• Entrez ID: 10260
• Gene name: DENN domain containing 4A
• Gene symbol: DENND4A
• Synonyms: IRLB, MYCPBP
• Chromosome: 15
• Chromosome location: 15q22.31
• Summary: This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT050274	hsa-miR-25-3p	CLASH	23622248
MIRT040677	hsa-miR-92b-3p	CLASH	23622248
MIRT932385	hsa-miR-1231	CLIP-seq
MIRT932386	hsa-miR-1273e	CLIP-seq
MIRT932387	hsa-miR-1299	CLIP-seq
MIRT932388	hsa-miR-139-5p	CLIP-seq
MIRT932389	hsa-miR-15a	CLIP-seq
MIRT932390	hsa-miR-15b	CLIP-seq
MIRT932391	hsa-miR-16	CLIP-seq
MIRT932392	hsa-miR-195	CLIP-seq
MIRT932393	hsa-miR-2964a-5p	CLIP-seq
MIRT932394	hsa-miR-3120-5p	CLIP-seq
MIRT932395	hsa-miR-3145-3p	CLIP-seq
MIRT932396	hsa-miR-3166	CLIP-seq
MIRT932397	hsa-miR-3201	CLIP-seq
MIRT932398	hsa-miR-320e	CLIP-seq
MIRT932399	hsa-miR-3671	CLIP-seq
MIRT932400	hsa-miR-3682-5p	CLIP-seq
MIRT932401	hsa-miR-3686	CLIP-seq
MIRT932402	hsa-miR-3920	CLIP-seq
MIRT932403	hsa-miR-424	CLIP-seq
MIRT932404	hsa-miR-4288	CLIP-seq
MIRT932405	hsa-miR-4327	CLIP-seq
MIRT932406	hsa-miR-4524	CLIP-seq
MIRT932407	hsa-miR-4652-3p	CLIP-seq
MIRT932408	hsa-miR-4682	CLIP-seq
MIRT932409	hsa-miR-4720-3p	CLIP-seq
MIRT932410	hsa-miR-4742-3p	CLIP-seq
MIRT932411	hsa-miR-4760-3p	CLIP-seq
MIRT932412	hsa-miR-4760-5p	CLIP-seq
MIRT932413	hsa-miR-4778-5p	CLIP-seq
MIRT932414	hsa-miR-4782-5p	CLIP-seq
MIRT932415	hsa-miR-4791	CLIP-seq
MIRT932416	hsa-miR-4804-3p	CLIP-seq
MIRT932417	hsa-miR-497	CLIP-seq
MIRT932418	hsa-miR-499a-5p	CLIP-seq
MIRT932419	hsa-miR-503	CLIP-seq
MIRT932420	hsa-miR-516b	CLIP-seq
MIRT932421	hsa-miR-543	CLIP-seq
MIRT932422	hsa-miR-579	CLIP-seq
MIRT932423	hsa-miR-607	CLIP-seq
MIRT932424	hsa-miR-626	CLIP-seq
MIRT932425	hsa-miR-627	CLIP-seq
MIRT932426	hsa-miR-632	CLIP-seq
MIRT932427	hsa-miR-646	CLIP-seq
MIRT932428	hsa-miR-664	CLIP-seq
MIRT932429	hsa-miR-922	CLIP-seq
MIRT932430	hsa-miR-924	CLIP-seq
MIRT932431	hsa-miR-1289	CLIP-seq
MIRT932389	hsa-miR-15a	CLIP-seq
MIRT932390	hsa-miR-15b	CLIP-seq
MIRT932391	hsa-miR-16	CLIP-seq
MIRT932392	hsa-miR-195	CLIP-seq
MIRT932396	hsa-miR-3166	CLIP-seq
MIRT932432	hsa-miR-3198	CLIP-seq
MIRT932399	hsa-miR-3671	CLIP-seq
MIRT932433	hsa-miR-3976	CLIP-seq
MIRT932403	hsa-miR-424	CLIP-seq
MIRT932434	hsa-miR-4294	CLIP-seq
MIRT932435	hsa-miR-4309	CLIP-seq
MIRT932406	hsa-miR-4524	CLIP-seq
MIRT932417	hsa-miR-497	CLIP-seq
MIRT932419	hsa-miR-503	CLIP-seq
MIRT932423	hsa-miR-607	CLIP-seq
MIRT932427	hsa-miR-646	CLIP-seq
MIRT932429	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003677	Function	DNA binding	NAS	8056341
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	20937701
GO:0005515	Function	Protein binding	IPI	15161933, 28514442
GO:0005634	Component	Nucleus	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006355	Process	Regulation of transcription, DNA-templated	NAS	8056341
GO:0031410	Component	Cytoplasmic vesicle	IBA	21873635
GO:0032483	Process	Regulation of Rab protein signal transduction	IBA	21873635
GO:0050790	Process	Regulation of catalytic activity	IEA

Other IDs

• MIM: 600382
• HGNC: 24321
• e!Ensembl: ENSG00000174485

Protein

• UniProt ID: Q7Z401
• Protein name: C-myc promoter-binding protein (DENN domain-containing protein 4A)
• Protein function: Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like e
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03456	uDENN	210 → 275	uDENN domain	Domain
  PF02141	DENN	308 → 492	DENN (AEX-3) domain	Family
  PF03455	dDENN	599 → 648	dDENN domain	Domain

• Sequence:

  MIEDKGPRVADYFVVAGLTDVSKPLEEEIHFNDACHKVAKPKEPITDVSVIIKSLGEEVP
  QDYICIDVTPTGLSADLNNGSLVGPQIYLCYRRGRDKPPLTDLGVLYDWKERLKQGCEII
  QSTPYGRPANISGSTSSQRIYITYRRASENMTQNTLAVTDICIIIPSKGESPPHTFCKVD
  KNLNNSMWGSAVYLCYKKSVAKTNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGAT
  IECWPSNSKYPLPVFSTFVLTGASAEKVYGAAIQFYEPYSEENLTEKQRLLLGLTSADGK
  SDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRYSISGPHVLPIEKHISHFMHKVPFPS
  PQRPRILVQLSPHDNLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHKILI
  HSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALADVLSAPCPFIVGIDSRYFDLYDP
  PPDVSCVDVDTNTISQIGDKKNVAWKILPKKPCKNLMNTLNNLHQQLAKLQQRPRDDGLM
  DLAINDYDFNSGKRLHMIDLEIQEAFLFFMASILKGYRSYLRPITQAPSETATDAASLFA
  LQAFLRSRDRSHQKFYNMMTKTQMFIRFIEECSFVSDKDASLAFFDDCVDKVDMDKSGEV
  RLIELDESFKSEHTVFVTPPEIPHLPNGEEPPLQYSYNGFPVLRNNLFERPEGFLQAKKN
  KLPSKSSSPNSPLPMFRRTKQEIKSAHKIAKRYSSIPQMWSRCLLRHCYGLWFICLPAYV
  KVCHSKVRALKTAYDVLKKMQSKKMDPPDEVCYRILMQLCGQYDQPVLAVRVLFEMQKAG
  IDPNAITYGYYNKAVLESTWPSRSRSGYFLWTKVRNVVLGVTQFKRALKKHAHLSQTTLS
  GGQSDLGYNSLSKDEVRRGDTSTEDIQEEKDKKGSDCSSLSESESTKGSADCLPKLSYQN
  SSSIVRLTGTSNNSAGKISGESMESTPELLLISSLEDTNETRNIQSRCFRKRHKSDNETN
  LQQQVVWGNRNRNLSGGVLMGFMLNRINQEATPGDIVEKLGADAKILSNVISKSTRPNTL
  DIGKPPLRSKRDSLEKESSDDDTPFDGSNYLADKVDSPVIFDLEDLDSETDVSKAGCVAT
  QNPKRIQRMNSSFSVKPFEKTDVATGFDPLSLLVAETEQQQKEEEEEDEDDSKSISTPSA
  RRDLAEEIVMYMNNMSSPLTSRTPSIDLQRACDDKLNKKSPPLVKACRRSSLPPNSPKPV
  RLTKSKSYTKSEEKPRDRLWSSPAFSPTCPFREESQDTLTHSSPSFNLDTLLVPKLDVLR
  NSMFTAGKGVAEKASKWYSRFTMYTTSSKDQSSDRTSLSSVGAQDSESTSLTDEDVCHEL
  EGPISSQETSATSGTKRIDLSRISLESSASLEGSLSKFALPGKSEVTSSFNASNTNIFQN
  YAMEVLISSCSRCRTCDCLVHDEEIMAGWTADDSNLNTTCPFCGNIFLPFLNIEIRDLRR
  PGRYFLKSSPSTENMHFPSSISSQTRQSCISTSASGLDTSALSVQGNFDLNSKSKLQENF
  CTRSIQIPANRSKTAMSKCPIFPMARSISTSGPLDKEDTGRQKLISTGSLPATLQGATDS
  LGLEWHLPSPDPVTVPYLSPLVVWKELESLLENEGDHAITVADFVDHHPIVFWNLVWYFR
  RLDLPSNLPGLILSSEHCNKYSKIPRHCMSEDSKYVLIQMLWDNMKLHQDPGQPLYILWN
  AHTQKYPMVHLLQKSDNSFNQELLKSMVKSIKMNDVYGPMSQILETLNKCPHFKRQRSLY
  REILFLSLVALGRENIDIDAFDKEYKMAYDRLTPSQVKSTHNCDRPPSTGVMECRKTFGE
  PYL

• Sequence length: 1863

Pathways

Reactome:

RAB GEFs exchange GTP for GDP on RABs

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203