SRRM1 (serine and arginine repetitive matrix 1)

Gene

• Entrez ID: 10250
• Gene name: Serine and arginine repetitive matrix 1
• Gene symbol: SRRM1
• Synonyms: 160-KD, POP101, SRM160
• Chromosome: 1
• Chromosome location: 1p36.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023485	hsa-miR-1-3p	Proteomics	18668040
MIRT043660	hsa-miR-326	CLASH	23622248
MIRT043025	hsa-miR-324-5p	CLASH	23622248
MIRT036777	hsa-miR-760	CLASH	23622248
MIRT530015	hsa-miR-4282	PAR-CLIP	22012620
MIRT530014	hsa-miR-499a-3p	PAR-CLIP	22012620
MIRT530013	hsa-miR-499b-3p	PAR-CLIP	22012620
MIRT530015	hsa-miR-4282	PAR-CLIP	22012620
MIRT530014	hsa-miR-499a-3p	PAR-CLIP	22012620
MIRT530013	hsa-miR-499b-3p	PAR-CLIP	22012620
MIRT1389781	hsa-miR-105	CLIP-seq
MIRT1389782	hsa-miR-1207-3p	CLIP-seq
MIRT1389783	hsa-miR-1252	CLIP-seq
MIRT1389784	hsa-miR-128	CLIP-seq
MIRT1389785	hsa-miR-1285	CLIP-seq
MIRT1389786	hsa-miR-1323	CLIP-seq
MIRT1389787	hsa-miR-186	CLIP-seq
MIRT1389788	hsa-miR-2113	CLIP-seq
MIRT1389789	hsa-miR-296-5p	CLIP-seq
MIRT1389790	hsa-miR-300	CLIP-seq
MIRT1389791	hsa-miR-3117-5p	CLIP-seq
MIRT1389792	hsa-miR-3138	CLIP-seq
MIRT1389793	hsa-miR-3187-5p	CLIP-seq
MIRT1389794	hsa-miR-3192	CLIP-seq
MIRT1389795	hsa-miR-3199	CLIP-seq
MIRT1389796	hsa-miR-320a	CLIP-seq
MIRT1389797	hsa-miR-320b	CLIP-seq
MIRT1389798	hsa-miR-320c	CLIP-seq
MIRT1389799	hsa-miR-320d	CLIP-seq
MIRT1389800	hsa-miR-3545-5p	CLIP-seq
MIRT1389801	hsa-miR-3646	CLIP-seq
MIRT1389802	hsa-miR-371-5p	CLIP-seq
MIRT1389803	hsa-miR-374c	CLIP-seq
MIRT1389804	hsa-miR-378g	CLIP-seq
MIRT1389805	hsa-miR-381	CLIP-seq
MIRT1389806	hsa-miR-3974	CLIP-seq
MIRT1389807	hsa-miR-4300	CLIP-seq
MIRT1389808	hsa-miR-4314	CLIP-seq
MIRT1389809	hsa-miR-4317	CLIP-seq
MIRT1389810	hsa-miR-4318	CLIP-seq
MIRT1389811	hsa-miR-4429	CLIP-seq
MIRT1389812	hsa-miR-4432	CLIP-seq
MIRT1389813	hsa-miR-4486	CLIP-seq
MIRT1389814	hsa-miR-4495	CLIP-seq
MIRT1389815	hsa-miR-4509	CLIP-seq
MIRT1389816	hsa-miR-450b-5p	CLIP-seq
MIRT1389817	hsa-miR-4536	CLIP-seq
MIRT1389818	hsa-miR-4633-3p	CLIP-seq
MIRT1389819	hsa-miR-4646-5p	CLIP-seq
MIRT1389820	hsa-miR-4652-3p	CLIP-seq
MIRT1389821	hsa-miR-4661-3p	CLIP-seq
MIRT1389822	hsa-miR-4661-5p	CLIP-seq
MIRT1389823	hsa-miR-4694-3p	CLIP-seq
MIRT1389824	hsa-miR-4744	CLIP-seq
MIRT1389825	hsa-miR-4778-5p	CLIP-seq
MIRT1389826	hsa-miR-4800-5p	CLIP-seq
MIRT1389827	hsa-miR-499-5p	CLIP-seq
MIRT1389828	hsa-miR-501-5p	CLIP-seq
MIRT1389829	hsa-miR-507	CLIP-seq
MIRT1389830	hsa-miR-520d-5p	CLIP-seq
MIRT1389831	hsa-miR-522	CLIP-seq
MIRT1389832	hsa-miR-524-5p	CLIP-seq
MIRT1389833	hsa-miR-548o	CLIP-seq
MIRT1389834	hsa-miR-557	CLIP-seq
MIRT1389835	hsa-miR-600	CLIP-seq
MIRT1389836	hsa-miR-605	CLIP-seq
MIRT1389837	hsa-miR-610	CLIP-seq
MIRT1389838	hsa-miR-612	CLIP-seq
MIRT1389839	hsa-miR-624	CLIP-seq
MIRT1389840	hsa-miR-655	CLIP-seq
MIRT1389841	hsa-miR-668	CLIP-seq
MIRT1389842	hsa-miR-888	CLIP-seq
MIRT1389843	hsa-miR-920	CLIP-seq
MIRT1389784	hsa-miR-128	CLIP-seq
MIRT1389785	hsa-miR-1285	CLIP-seq
MIRT2116764	hsa-miR-203	CLIP-seq
MIRT2116765	hsa-miR-214	CLIP-seq
MIRT1389790	hsa-miR-300	CLIP-seq
MIRT1389791	hsa-miR-3117-5p	CLIP-seq
MIRT2116766	hsa-miR-3120-5p	CLIP-seq
MIRT2116767	hsa-miR-3128	CLIP-seq
MIRT2116768	hsa-miR-3160-5p	CLIP-seq
MIRT1389793	hsa-miR-3187-5p	CLIP-seq
MIRT1389800	hsa-miR-3545-5p	CLIP-seq
MIRT2116769	hsa-miR-3619-5p	CLIP-seq
MIRT1389804	hsa-miR-378g	CLIP-seq
MIRT1389805	hsa-miR-381	CLIP-seq
MIRT2116770	hsa-miR-4291	CLIP-seq
MIRT1389808	hsa-miR-4314	CLIP-seq
MIRT2116771	hsa-miR-4470	CLIP-seq
MIRT1389813	hsa-miR-4486	CLIP-seq
MIRT1389814	hsa-miR-4495	CLIP-seq
MIRT1389820	hsa-miR-4652-3p	CLIP-seq
MIRT2116772	hsa-miR-4742-5p	CLIP-seq
MIRT2116773	hsa-miR-4793-5p	CLIP-seq
MIRT2116774	hsa-miR-579	CLIP-seq
MIRT1389838	hsa-miR-612	CLIP-seq
MIRT2116775	hsa-miR-664	CLIP-seq
MIRT2116776	hsa-miR-761	CLIP-seq
MIRT2116777	hsa-miR-922	CLIP-seq
MIRT1389785	hsa-miR-1285	CLIP-seq
MIRT1389786	hsa-miR-1323	CLIP-seq
MIRT1389787	hsa-miR-186	CLIP-seq
MIRT2116765	hsa-miR-214	CLIP-seq
MIRT1389789	hsa-miR-296-5p	CLIP-seq
MIRT1389790	hsa-miR-300	CLIP-seq
MIRT1389791	hsa-miR-3117-5p	CLIP-seq
MIRT2116766	hsa-miR-3120-5p	CLIP-seq
MIRT1389792	hsa-miR-3138	CLIP-seq
MIRT1389793	hsa-miR-3187-5p	CLIP-seq
MIRT1389800	hsa-miR-3545-5p	CLIP-seq
MIRT2116769	hsa-miR-3619-5p	CLIP-seq
MIRT1389803	hsa-miR-374c	CLIP-seq
MIRT1389804	hsa-miR-378g	CLIP-seq
MIRT1389805	hsa-miR-381	CLIP-seq
MIRT2339179	hsa-miR-3908	CLIP-seq
MIRT2339180	hsa-miR-3942-5p	CLIP-seq
MIRT2116770	hsa-miR-4291	CLIP-seq
MIRT2339181	hsa-miR-4313	CLIP-seq
MIRT1389808	hsa-miR-4314	CLIP-seq
MIRT1389810	hsa-miR-4318	CLIP-seq
MIRT1389813	hsa-miR-4486	CLIP-seq
MIRT1389814	hsa-miR-4495	CLIP-seq
MIRT1389816	hsa-miR-450b-5p	CLIP-seq
MIRT1389820	hsa-miR-4652-3p	CLIP-seq
MIRT2339182	hsa-miR-4666-5p	CLIP-seq
MIRT2339183	hsa-miR-4703-5p	CLIP-seq
MIRT2116772	hsa-miR-4742-5p	CLIP-seq
MIRT2116773	hsa-miR-4793-5p	CLIP-seq
MIRT1389826	hsa-miR-4800-5p	CLIP-seq
MIRT2339184	hsa-miR-495	CLIP-seq
MIRT1389829	hsa-miR-507	CLIP-seq
MIRT1389833	hsa-miR-548o	CLIP-seq
MIRT1389834	hsa-miR-557	CLIP-seq
MIRT2116774	hsa-miR-579	CLIP-seq
MIRT1389835	hsa-miR-600	CLIP-seq
MIRT1389836	hsa-miR-605	CLIP-seq
MIRT1389838	hsa-miR-612	CLIP-seq
MIRT1389839	hsa-miR-624	CLIP-seq
MIRT2339185	hsa-miR-653	CLIP-seq
MIRT1389840	hsa-miR-655	CLIP-seq
MIRT1389841	hsa-miR-668	CLIP-seq
MIRT2116776	hsa-miR-761	CLIP-seq
MIRT2116777	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000375	Process	RNA splicing, via transesterification reactions	TAS	9531537
GO:0000398	Process	MRNA splicing, via spliceosome	IC	11991638
GO:0000398	Process	MRNA splicing, via spliceosome	TAS
GO:0003677	Function	DNA binding	IEA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	25416956, 26871637, 32296183
GO:0005634	Component	Nucleus	TAS	9531537
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006405	Process	RNA export from nucleus	TAS
GO:0006406	Process	MRNA export from nucleus	TAS
GO:0008380	Process	RNA splicing	TAS	9531537
GO:0016363	Component	Nuclear matrix	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0031124	Process	MRNA 3'-end processing	TAS
GO:0071013	Component	Catalytic step 2 spliceosome	IDA	11991638

Other IDs

• MIM: 605975
• HGNC: 16638
• e!Ensembl: ENSG00000133226

Protein

• UniProt ID: Q8IYB3
• Protein name: Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein)
• Protein function: Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and
• PDB: 1MP1, 6FF4, 6FF7, 7ABG, 7ABH, 7ABI, 7DVQ, 8I0P, 8I0R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01480	PWI	46 → 117	PWI domain	Family

• Sequence:

  MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEIL
  GFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIP
  SAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSP
  SPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATS
  TSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRR
  RHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSS
  SSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQS
  NRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQ
  QRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKET
  SPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPI
  QRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKH
  RKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRP
  IRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNW
  SPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAA
  AAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQV
  SPQS

• Sequence length: 904

Pathways

KEGG:

Nucleocytoplasmic transport
mRNA surveillance pathway

Reactome:

Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Alopecia	Alopecia		28196072