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GLYAT (glycine-N-acyltransferase)

Gene

10249

Glycine-N-acyltransferase

GLYAT

ACGNAT, CAT, GAT

11q12.1

The glycine-N-acyltransferase protein conjugates glycine with acyl-CoA substrates in the mitochondria. The protein is thought to be important in the detoxification of endogenous and xenobiotic acyl-CoA`s. Two transcript variants encoding different isoform

Show/Hide all(101)

miRTarBase ID	miRNA	Experiments	Reference
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT679250	hsa-miR-5693	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT679249	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT678450	hsa-miR-498	HITS-CLIP	23824327
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT679250	hsa-miR-5693	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT679249	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT678465	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT678464	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT678463	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT678462	hsa-miR-1539	HITS-CLIP	23824327
MIRT678461	hsa-miR-3193	HITS-CLIP	23824327
MIRT678460	hsa-miR-1281	HITS-CLIP	23824327
MIRT678459	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT678458	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT678457	hsa-miR-1976	HITS-CLIP	23824327
MIRT678456	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT678455	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT678454	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT678453	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT678452	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT678451	hsa-miR-4284	HITS-CLIP	23824327
MIRT678450	hsa-miR-498	HITS-CLIP	23824327
MIRT1022090	hsa-miR-1289	CLIP-seq
MIRT1022091	hsa-miR-142-5p	CLIP-seq
MIRT1022092	hsa-miR-185	CLIP-seq
MIRT1022093	hsa-miR-3149	CLIP-seq
MIRT1022094	hsa-miR-3198	CLIP-seq
MIRT1022095	hsa-miR-340	CLIP-seq
MIRT1022096	hsa-miR-4294	CLIP-seq
MIRT1022097	hsa-miR-4306	CLIP-seq
MIRT1022098	hsa-miR-4309	CLIP-seq
MIRT1022099	hsa-miR-4464	CLIP-seq
MIRT1022100	hsa-miR-4503	CLIP-seq
MIRT1022101	hsa-miR-4644	CLIP-seq
MIRT1022102	hsa-miR-4722-5p	CLIP-seq
MIRT1022103	hsa-miR-4748	CLIP-seq
MIRT1022104	hsa-miR-4768-3p	CLIP-seq
MIRT1022105	hsa-miR-494	CLIP-seq
MIRT1022106	hsa-miR-548m	CLIP-seq
MIRT1022107	hsa-miR-924	CLIP-seq
MIRT1022108	hsa-miR-1183	CLIP-seq
MIRT1022109	hsa-miR-1343	CLIP-seq
MIRT1022110	hsa-miR-28-5p	CLIP-seq
MIRT1022111	hsa-miR-3074-5p	CLIP-seq
MIRT1022112	hsa-miR-3139	CLIP-seq
MIRT1022113	hsa-miR-3690	CLIP-seq
MIRT1022114	hsa-miR-4254	CLIP-seq
MIRT1022115	hsa-miR-4733-5p	CLIP-seq
MIRT1022116	hsa-miR-4742-3p	CLIP-seq
MIRT1022117	hsa-miR-708	CLIP-seq
MIRT1022118	hsa-miR-889	CLIP-seq
MIRT2539805	hsa-miR-3689a-5p	CLIP-seq
MIRT2539806	hsa-miR-3689b	CLIP-seq
MIRT2539807	hsa-miR-3689e	CLIP-seq
MIRT2539808	hsa-miR-3689f	CLIP-seq
MIRT2539809	hsa-miR-513a-3p	CLIP-seq
MIRT2539810	hsa-miR-944	CLIP-seq

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA	22475485
GO:0005739	Component	Mitochondrion	ISS
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006544	Process	Glycine metabolic process	IBA	21873635
GO:0006544	Process	Glycine metabolic process	IDA	22475485
GO:0006544	Process	Glycine metabolic process	ISS
GO:0006637	Process	Acyl-CoA metabolic process	TAS	7802672
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0009636	Process	Response to toxic substance	IEA
GO:0016410	Function	N-acyltransferase activity	IBA	21873635
GO:0016746	Function	Transferase activity, transferring acyl groups	TAS	9202629
GO:0032787	Process	Monocarboxylic acid metabolic process	ISS
GO:0047961	Function	Glycine N-acyltransferase activity	IBA	21873635
GO:0047961	Function	Glycine N-acyltransferase activity	IDA	22475485
GO:0047962	Function	Glycine N-benzoyltransferase activity	IBA	21873635
GO:0047962	Function	Glycine N-benzoyltransferase activity	IDA	22475485
GO:0047962	Function	Glycine N-benzoyltransferase activity	ISS
GO:1901787	Process	Benzoyl-CoA metabolic process	IDA	22475485

MIM	HGNC	e!Ensembl
607424	13734	ENSG00000149124

Protein

UniProt ID

Q6IB77

Protein name

Glycine N-acyltransferase (EC 2.3.1.13) (Acyl-CoA:glycine N-acyltransferase) (AAc) (Aralkyl acyl-CoA N-acyltransferase) (Aralkyl acyl-CoA:amino acid N-acyltransferase) (Benzoyl-coenzyme A:glycine N-acyltransferase) (Glycine N-benzoyltransferase) (EC 2.3.1

Protein function

Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF06021	Gly_acyl_tr_N	2 → 206	Aralkyl acyl-CoA:amino acid N-acyltransferase	Family
PF08444	Gly_acyl_tr_C	207 → 295	Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region	Family

Sequence

MMLPLQGAQMLQMLEKSLRKSLPASLKVYGTVFHINHGNPFNLKAVVDKWPDFNTVVVCP
QEQDMTDDLDHYTNTYQIYSKDPQNCQEFLGSPELINWKQHLQIQSSQPSLNEAIQNLAA
IKSFKVKQTQRILYMAAETAKELTPFLLKSKILSPNGGKPKAINQEMFKLSSMDVTHAHL
VNKFWHFGGNERSQRFIERCIQTFPTCCLLGPEGTPVCWDLMDQTGEMRMAGTLPEYRLH
GLVTYVIYSHAQKLGKLGFPVYSHVDYSNEAMQKMSYTLQHVPIPRSWNQWNCVPL

Sequence length

296

Interactions

View interactions

	Reactome
			Conjugation of salicylate with glycine Conjugation of benzoate with glycine

Associated diseases

Show/Hide Causal Diseases (2)

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	26192919
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Show/Hide Unknown Diseases (6)

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Bipolar disorder	Bipolar Disorder		23140658
Cardiovascular diseases	Cardiovascular Diseases		30595370
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26192919, 26974007
Ulcerative colitis	Ulcerative Colitis		26974007, 26192919

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