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PLIN3 (perilipin 3)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10226
Gene nameGene Name - the full gene name approved by the HGNC.
Perilipin 3
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PLIN3
SynonymsGene synonyms aliases
M6PRBP1, PP17, TIP47
ChromosomeChromosome number
19
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19p13.3
SummarySummary of gene provided in NCBI Entrez Gene.
Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs,
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016368 hsa-miR-193b-3p Proteomics 21512034
MIRT021117 hsa-miR-186-5p Sequencing 20371350
MIRT023413 hsa-miR-30b-5p Sequencing 20371350
MIRT025384 hsa-miR-34a-5p Proteomics 21566225
MIRT025384 hsa-miR-34a-5p Proteomics 21566225
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 19490898, 23593007, 25416956, 32296183, 32814053
GO:0005737 Component Cytoplasm TAS 9590177
GO:0005768 Component Endosome TAS 9590177
GO:0005794 Component Golgi apparatus TAS 9590177
GO:0005811 Component Lipid droplet IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O60664
Protein name Perilipin-3 (47 kDa mannose 6-phosphate receptor-binding protein) (47 kDa MPR-binding protein) (Cargo selection protein TIP47) (Mannose-6-phosphate receptor-binding protein 1) (Placental protein 17) (PP17)
Protein function Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03036 Perilipin
18 425
Perilipin family
Family
Sequence
Sequence length 434
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
Reactome
    Triglyceride catabolism
Retrograde transport at the Trans-Golgi-Network
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Lung carcinoma Carcinoma of lung rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193 28604730

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