MEI4 (meiotic double-stranded break formation protein 4)

Gene

• Entrez ID: 101928601
• Gene name: Meiotic double-stranded break formation protein 4
• Gene symbol: MEI4
• Synonyms: -
• Chromosome: 6
• Chromosome location: 6q14.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT740506	hsa-miR-7109-3p	HITS-CLIP	19536157
MIRT740507	hsa-miR-3614-3p	HITS-CLIP	19536157
MIRT740508	hsa-miR-617	HITS-CLIP	19536157
MIRT740509	hsa-miR-6505-3p	HITS-CLIP	19536157
MIRT740510	hsa-miR-3164	HITS-CLIP	19536157
MIRT740511	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT740512	hsa-miR-513a-5p	HITS-CLIP	19536157
MIRT740513	hsa-miR-27a-3p	HITS-CLIP	19536157
MIRT740514	hsa-miR-27b-3p	HITS-CLIP	19536157
MIRT740515	hsa-miR-587	HITS-CLIP	19536157

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000800	Component	Lateral element	IBA	21873635
GO:0000800	Component	Lateral element	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0006310	Process	DNA recombination	IEA
GO:0007129	Process	Homologous chromosome pairing at meiosis	IBA	21873635
GO:0007129	Process	Homologous chromosome pairing at meiosis	ISS
GO:0007283	Process	Spermatogenesis	IBA	21873635
GO:0007283	Process	Spermatogenesis	ISS
GO:0042138	Process	Meiotic DNA double-strand break formation	IBA	21873635
GO:0042138	Process	Meiotic DNA double-strand break formation	ISS
GO:0048477	Process	Oogenesis	IBA	21873635
GO:0048477	Process	Oogenesis	ISS

Other IDs

• MIM: 618417
• HGNC: 43638
• e!Ensembl: ENSG00000269964

Protein

• UniProt ID: A8MW99
• Protein name: Meiosis-specific protein MEI4
• Protein function: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13971	Mei4	1 → 378	Meiosis-specific protein Mei4	Family

• Sequence:

  MDVQKWYLRTSKLALALAIIRSKPADKSSREYTEHLAMLLSEEQSKWRSKVEILEAEVMQ
  LRQKLLVSRLCSGSFKSGYVSSQLEAQEPKSSESTLTSMEDSGCDLSNEQRTESSDLSQH
  FVESCTPTHFPPLPLVKRPCAILQNPLSSHMQFLQYLLELKNLTESGNLKRDLTHFEKDS
  STVSDSVFQLLDGLITFYRNPKLPFSRFWTEAVGTLASLISDYNLSSHILKKCSKKLEEF
  EKTLLHAILGNNHINQFQVQHYVSQSLVTLGNCSLLRKSIISLLLSEVNGFADDLGAINQ
  EQASYDVSRYENIFYLFWVLEQLLQKETEEGNTSSIGHDDQEIKKFLQKHDETIFQLSDA
  FPLFTFYLWRVGILLSSAQIETLRK

• Sequence length: 385

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	21725308