CDK3 (cyclin dependent kinase 3)

Gene

• Entrez ID: 1018
• Gene name: Cyclin dependent kinase 3
• Gene symbol: CDK3
• Synonyms: -
• Chromosome: 17
• Chromosome location: 17q25.1
• Summary: This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT053431	hsa-miR-512-5p	Microarray	23807165
MIRT731162	hsa-miR-873-5p	5.0	25531331
MIRT731162	hsa-miR-873-5p	5.0	25531331
MIRT881138	hsa-miR-1302	CLIP-seq
MIRT881139	hsa-miR-3122	CLIP-seq
MIRT881140	hsa-miR-3199	CLIP-seq
MIRT881141	hsa-miR-3545-3p	CLIP-seq
MIRT881142	hsa-miR-3646	CLIP-seq
MIRT881143	hsa-miR-3913-5p	CLIP-seq
MIRT881144	hsa-miR-4298	CLIP-seq
MIRT881145	hsa-miR-4539	CLIP-seq
MIRT881146	hsa-miR-4724-5p	CLIP-seq
MIRT881147	hsa-miR-4740-5p	CLIP-seq
MIRT1961005	hsa-miR-1292	CLIP-seq
MIRT1961006	hsa-miR-1343	CLIP-seq
MIRT1961007	hsa-miR-1976	CLIP-seq
MIRT1961008	hsa-miR-4267	CLIP-seq
MIRT1961009	hsa-miR-450b-3p	CLIP-seq
MIRT1961010	hsa-miR-4713-3p	CLIP-seq
MIRT1961011	hsa-miR-638	CLIP-seq
MIRT1961012	hsa-miR-769-3p	CLIP-seq
MIRT1961005	hsa-miR-1292	CLIP-seq
MIRT1961006	hsa-miR-1343	CLIP-seq
MIRT1961007	hsa-miR-1976	CLIP-seq
MIRT1961008	hsa-miR-4267	CLIP-seq
MIRT1961009	hsa-miR-450b-3p	CLIP-seq
MIRT1961010	hsa-miR-4713-3p	CLIP-seq
MIRT1961011	hsa-miR-638	CLIP-seq
MIRT1961012	hsa-miR-769-3p	CLIP-seq
MIRT2385859	hsa-miR-1207-3p	CLIP-seq
MIRT2385860	hsa-miR-1827	CLIP-seq
MIRT2385861	hsa-miR-3612	CLIP-seq
MIRT2385862	hsa-miR-4731-5p	CLIP-seq
MIRT2385863	hsa-miR-486-3p	CLIP-seq
MIRT2385864	hsa-miR-646	CLIP-seq
MIRT2385865	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS	8846921
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0005515	Function	Protein binding	IPI	15084261, 22939624, 23602568, 24218572, 25344755, 28514442, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006974	Process	Cellular response to DNA damage stimulus	IDA	24550317
GO:0008283	Process	Cell population proliferation	TAS	18794154
GO:0045023	Process	G0 to G1 transition	TAS	15084261
GO:0051301	Process	Cell division	IEA
GO:0051726	Process	Regulation of cell cycle	IEA

Other IDs

• MIM: 123828
• HGNC: 1772
• e!Ensembl: ENSG00000250506

Protein

• UniProt ID: Q00526
• Protein name: Cyclin-dependent kinase 3 (EC 2.7.11.22) (Cell division protein kinase 3)
• Protein function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and C
• PDB: 7XQK, 8H4R
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	4 → 286	Protein kinase domain	Domain

• Sequence:

  MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH
  PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS
  HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY
  TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSF
  PKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVL
  QRFRH

• Sequence length: 305

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888