CDK2 (cyclin dependent kinase 2)

Gene

• Entrez ID: 1017
• Gene name: Cyclin dependent kinase 2
• Gene symbol: CDK2
• Synonyms: CDKN2, p33(CDK2)
• Chromosome: 12
• Chromosome location: 12q13.2
• Summary: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004283	hsa-miR-124-3p	Luciferase reporter assay, Western blot	19404929
MIRT004764	hsa-miR-103a-3p	Luciferase reporter assay, qRT-PCR, Western blot	20886090
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005672	hsa-miR-302d-3p	Luciferase reporter assay, Microarray, Northern blot, Western blot	21062975
MIRT005461	hsa-miR-885-5p	Luciferase reporter assay, Northern blot, qRT-PCR, Western blot	21233845
MIRT006766	hsa-miR-372-3p	FACS, GFP reporter assay, qRT-PCR, Western blot	21646351
MIRT006766	hsa-miR-372-3p	FACS, GFP reporter assay, qRT-PCR, Western blot	21646351
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT007019	hsa-miR-376a-3p	Luciferase reporter assay	21556037
MIRT020948	hsa-miR-155-5p	Proteomics	18668040
MIRT004283	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT030063	hsa-miR-26b-5p	Microarray	19088304
MIRT047445	hsa-miR-10b-5p	CLASH	23622248
MIRT046257	hsa-miR-23b-3p	CLASH	23622248
MIRT044112	hsa-miR-361-5p	CLASH	23622248
MIRT053070	hsa-miR-223-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	24137330
MIRT006766	hsa-miR-372-3p	Luciferase reporter assay, Western blot, qRT-PCR	23479742
MIRT053775	hsa-miR-302a-3p	ChIP-seq, Flow, Microarray, qRT-PCR, Western blot	24861464
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT054309	hsa-miR-29a-3p	qRT-PCR, Western blot	25889078
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT438189	hsa-miR-524-5p	Luciferase reporter assay	24194606
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT731124	hsa-miR-638	qRT-PCR, Luciferase reporter assay, Western blot	25451924
MIRT732203	hsa-miR-200c-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26248649
MIRT732203	hsa-miR-200c-3p	Immunohistochemistry, Luciferase reporter assay, Microarray, qRT-PCR, Western blot	26248649
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732289	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	26701625
MIRT513331	hsa-miR-2909	PAR-CLIP	26701625
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	26701625
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	26701625
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	26701625
MIRT570129	hsa-miR-4492	PAR-CLIP	26701625
MIRT570128	hsa-miR-4498	PAR-CLIP	26701625
MIRT513338	hsa-miR-4784	PAR-CLIP	26701625
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	26701625
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	26701625
MIRT513340	hsa-miR-5186	PAR-CLIP	26701625
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	26701625
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	26701625
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	26701625
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	26701625
MIRT570126	hsa-miR-762	PAR-CLIP	26701625
MIRT513334	hsa-miR-765	PAR-CLIP	26701625
MIRT513336	hsa-miR-766-5p	PAR-CLIP	26701625
MIRT735447	hsa-miR-335-3p	qRT-PCR	32165872
MIRT659646	hsa-miR-622	HITS-CLIP	23824327
MIRT659644	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT659645	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT659643	hsa-miR-532-3p	HITS-CLIP	23824327
MIRT659642	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT659641	hsa-miR-6800-5p	HITS-CLIP	23824327
MIRT659640	hsa-miR-6802-5p	HITS-CLIP	23824327
MIRT659638	hsa-miR-7977	HITS-CLIP	23824327
MIRT659639	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	20371350
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	20371350
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	20371350
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	20371350
MIRT513340	hsa-miR-5186	PAR-CLIP	20371350
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	20371350
MIRT513338	hsa-miR-4784	PAR-CLIP	20371350
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	20371350
MIRT513336	hsa-miR-766-5p	PAR-CLIP	20371350
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	20371350
MIRT513334	hsa-miR-765	PAR-CLIP	20371350
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	20371350
MIRT570129	hsa-miR-4492	PAR-CLIP	20371350
MIRT570128	hsa-miR-4498	PAR-CLIP	20371350
MIRT570127	hsa-miR-5001-5p	PAR-CLIP	20371350
MIRT570126	hsa-miR-762	PAR-CLIP	20371350
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	20371350
MIRT513331	hsa-miR-2909	PAR-CLIP	20371350
MIRT513344	hsa-miR-6757-3p	PAR-CLIP	23446348
MIRT513343	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT513342	hsa-miR-4446-3p	PAR-CLIP	23446348
MIRT513341	hsa-miR-3158-3p	PAR-CLIP	23446348
MIRT513340	hsa-miR-5186	PAR-CLIP	23446348
MIRT513339	hsa-miR-3150b-3p	PAR-CLIP	23446348
MIRT513338	hsa-miR-4784	PAR-CLIP	23446348
MIRT513337	hsa-miR-6804-5p	PAR-CLIP	23446348
MIRT513336	hsa-miR-766-5p	PAR-CLIP	23446348
MIRT513335	hsa-miR-7154-3p	PAR-CLIP	23446348
MIRT513334	hsa-miR-765	PAR-CLIP	23446348
MIRT513333	hsa-miR-6894-5p	PAR-CLIP	23446348
MIRT513332	hsa-miR-1296-5p	PAR-CLIP	23446348
MIRT513331	hsa-miR-2909	PAR-CLIP	23446348
MIRT479490	hsa-miR-3125	PAR-CLIP	23592263
MIRT479489	hsa-miR-3916	PAR-CLIP	23592263
MIRT479488	hsa-miR-6859-5p	PAR-CLIP	23592263
MIRT479487	hsa-miR-362-5p	PAR-CLIP	23592263
MIRT479486	hsa-miR-500b-5p	PAR-CLIP	23592263
MIRT479485	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT479484	hsa-miR-4257	PAR-CLIP	23592263
MIRT479483	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT479481	hsa-miR-4270	PAR-CLIP	23592263
MIRT479482	hsa-miR-4441	PAR-CLIP	23592263
MIRT479480	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT479479	hsa-miR-212-5p	PAR-CLIP	23592263
MIRT479478	hsa-miR-3189-3p	PAR-CLIP	23592263
MIRT479477	hsa-miR-4772-5p	PAR-CLIP	23592263
MIRT479476	hsa-miR-8071	PAR-CLIP	23592263
MIRT479475	hsa-miR-450b-3p	PAR-CLIP	23592263
MIRT479474	hsa-miR-769-3p	PAR-CLIP	23592263
MIRT755832	hsa-miR-646	Western blotting, qRT-PCR, in vitro cullelar assays, Flow cytometry	37155307
MIRT880948	hsa-miR-18a	CLIP-seq
MIRT880949	hsa-miR-18b	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT880951	hsa-miR-4735-3p	CLIP-seq
MIRT880952	hsa-miR-4761-5p	CLIP-seq
MIRT880953	hsa-miR-520d-5p	CLIP-seq
MIRT880954	hsa-miR-616	CLIP-seq
MIRT880955	hsa-miR-1293	CLIP-seq
MIRT880956	hsa-miR-3129-3p	CLIP-seq
MIRT880957	hsa-miR-3153	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT880959	hsa-miR-3165	CLIP-seq
MIRT880960	hsa-miR-3179	CLIP-seq
MIRT880961	hsa-miR-3199	CLIP-seq
MIRT880962	hsa-miR-3612	CLIP-seq
MIRT880963	hsa-miR-3942-5p	CLIP-seq
MIRT880964	hsa-miR-3975	CLIP-seq
MIRT880965	hsa-miR-4443	CLIP-seq
MIRT880966	hsa-miR-4483	CLIP-seq
MIRT880967	hsa-miR-4515	CLIP-seq
MIRT880968	hsa-miR-4652-5p	CLIP-seq
MIRT880969	hsa-miR-4703-5p	CLIP-seq
MIRT880970	hsa-miR-4716-3p	CLIP-seq
MIRT880971	hsa-miR-548t	CLIP-seq
MIRT880972	hsa-miR-625	CLIP-seq
MIRT880973	hsa-miR-650	CLIP-seq
MIRT880974	hsa-miR-660	CLIP-seq
MIRT1960974	hsa-miR-1224-3p	CLIP-seq
MIRT1960975	hsa-miR-1263	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT1960976	hsa-miR-3622a-3p	CLIP-seq
MIRT1960977	hsa-miR-3622b-3p	CLIP-seq
MIRT1960978	hsa-miR-3651	CLIP-seq
MIRT1960979	hsa-miR-4756-3p	CLIP-seq
MIRT1960980	hsa-miR-4762-5p	CLIP-seq
MIRT1960981	hsa-miR-509-3p	CLIP-seq
MIRT1960982	hsa-miR-548al	CLIP-seq
MIRT2197677	hsa-miR-124	CLIP-seq
MIRT2197678	hsa-miR-200b	CLIP-seq
MIRT2197679	hsa-miR-200c	CLIP-seq
MIRT2197680	hsa-miR-214	CLIP-seq
MIRT880958	hsa-miR-3154	CLIP-seq
MIRT2197681	hsa-miR-3188	CLIP-seq
MIRT2197682	hsa-miR-3619-5p	CLIP-seq
MIRT2197683	hsa-miR-3652	CLIP-seq
MIRT2197684	hsa-miR-3659	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197686	hsa-miR-3714	CLIP-seq
MIRT2197687	hsa-miR-3910	CLIP-seq
MIRT2197688	hsa-miR-3926	CLIP-seq
MIRT2197689	hsa-miR-3938	CLIP-seq
MIRT2197690	hsa-miR-429	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197692	hsa-miR-4430	CLIP-seq
MIRT2197693	hsa-miR-4459	CLIP-seq
MIRT2197694	hsa-miR-4477b	CLIP-seq
MIRT2197695	hsa-miR-451b	CLIP-seq
MIRT2197696	hsa-miR-4658	CLIP-seq
MIRT2197697	hsa-miR-4695-5p	CLIP-seq
MIRT2197698	hsa-miR-4713-3p	CLIP-seq
MIRT2197699	hsa-miR-4715-5p	CLIP-seq
MIRT880950	hsa-miR-4717-3p	CLIP-seq
MIRT2197700	hsa-miR-4722-5p	CLIP-seq
MIRT2197701	hsa-miR-4724-5p	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197703	hsa-miR-4742-3p	CLIP-seq
MIRT2197704	hsa-miR-506	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197706	hsa-miR-519a	CLIP-seq
MIRT2197707	hsa-miR-519b-3p	CLIP-seq
MIRT2197708	hsa-miR-519c-3p	CLIP-seq
MIRT2197709	hsa-miR-548s	CLIP-seq
MIRT2197710	hsa-miR-571	CLIP-seq
MIRT2197711	hsa-miR-574-5p	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197713	hsa-miR-630	CLIP-seq
MIRT2197714	hsa-miR-647	CLIP-seq
MIRT2197715	hsa-miR-761	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq
MIRT2197685	hsa-miR-3679-3p	CLIP-seq
MIRT2197691	hsa-miR-4420	CLIP-seq
MIRT2197702	hsa-miR-4738-3p	CLIP-seq
MIRT2197705	hsa-miR-5096	CLIP-seq
MIRT2197712	hsa-miR-579	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ARNT	Repression	21544813
DDIT3	Unknown	20017906
E2F4	Unknown	22447046
GLI1	Activation	20647328
IRF1	Repression	22200613
KAT2B	Repression	19525977
MITF	Unknown	15607961
MYC	Unknown	21384303
TP53	Repression	12732645

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA	21873635
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS
GO:0000086	Process	G2/M transition of mitotic cell cycle	NAS	1653904
GO:0000086	Process	G2/M transition of mitotic cell cycle	TAS
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA	21873635
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IDA	1312467, 8692841
GO:0004674	Function	Protein serine/threonine kinase activity	IGI	26996940
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	IDA	21596315
GO:0004693	Function	Cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	2227411, 7630397, 8242750, 8521818, 8601310, 8684460, 8756328, 8756624, 9840943, 10330164, 11463386, 11980914, 12244298, 12361598, 12839962, 12941338, 15107404, 15178429, 15189033, 15232106, 15239650, 15530371, 15611625, 15890360, 16061792, 16209941, 16326706, 16327805, 16431923, 167
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	10767298
GO:0005654	Component	Nucleoplasm	IDA	8245034
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	10767298
GO:0005768	Component	Endosome	IDA	21262353
GO:0005813	Component	Centrosome	IDA
GO:0005813	Component	Centrosome	TAS	19238148
GO:0005829	Component	Cytosol	TAS
GO:0006260	Process	DNA replication	TAS	19238148
GO:0006281	Process	DNA repair	IEA
GO:0006468	Process	Protein phosphorylation	IBA	21873635
GO:0006468	Process	Protein phosphorylation	IDA	12944431, 28666995
GO:0006468	Process	Protein phosphorylation	IMP	29203878
GO:0006977	Process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	TAS
GO:0007099	Process	Centriole replication	IMP	26297806
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007265	Process	Ras protein signal transduction	IEP	9054499
GO:0008284	Process	Positive regulation of cell population proliferation	IBA	21873635
GO:0008284	Process	Positive regulation of cell population proliferation	IDA	10767298
GO:0010389	Process	Regulation of G2/M transition of mitotic cell cycle	IBA	21873635
GO:0010468	Process	Regulation of gene expression	IBA	21873635
GO:0015030	Component	Cajal body	IDA	10995387
GO:0016572	Process	Histone phosphorylation	IDA	11746698
GO:0018105	Process	Peptidyl-serine phosphorylation	IDA	23184662
GO:0019904	Function	Protein domain specific binding	IPI	8876165, 15024385
GO:0030332	Function	Cyclin binding	IBA	21873635
GO:0030332	Function	Cyclin binding	IDA	1653904, 23781148
GO:0030332	Function	Cyclin binding	IPI	1312467, 15024385
GO:0031145	Process	Anaphase-promoting complex-dependent catabolic process	TAS
GO:0031571	Process	Mitotic G1 DNA damage checkpoint	TAS	21319273
GO:0035173	Function	Histone kinase activity	IDA	8692841
GO:0046872	Function	Metal ion binding	IEA
GO:0051298	Process	Centrosome duplication	TAS	19238148
GO:0051301	Process	Cell division	IEA
GO:0051321	Process	Meiotic cell cycle	TAS	19238148
GO:0060968	Process	Regulation of gene silencing	IDA	20935635
GO:0071732	Process	Cellular response to nitric oxide	TAS	20079829
GO:0097123	Component	Cyclin A1-CDK2 complex	IDA	18305109
GO:0097124	Component	Cyclin A2-CDK2 complex	IDA	1312467, 8684460, 8876165, 11746698, 15024385
GO:0097134	Component	Cyclin E1-CDK2 complex	IDA	18305109
GO:0097135	Component	Cyclin E2-CDK2 complex	IDA	18305109
GO:0097472	Function	Cyclin-dependent protein kinase activity	IDA	1312467, 28666995
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	TAS

Other IDs

• MIM: 116953
• HGNC: 1771
• e!Ensembl: ENSG00000123374

Protein

• UniProt ID: P24941
• Protein name: Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
• Protein function: Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis (PubMed:10499802, PubMed:10884347, PubMed:10995386, PubMed:10995387, PubMed:11051553, PubMed:11113184, PubMed:12944431,
• PDB: 1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII, 1GIJ, 1GY3, 1GZ8, 1H00, 1H01, 1H07, 1H08, 1H0V, 1H0W, 1H1P, 1H1Q, 1H1R, 1H1S, 1H24, 1H25, 1H26, 1H27, 1H28, 1HCK, 1HCL, 1JST, 1JSU, 1JSV, 1JVP, 1KE5, 1KE6, 1KE7, 1KE8, 1KE9, 1OGU, 1OI9, 1OIQ, 1OIR
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	4 → 286	Protein kinase domain	Domain

• Sequence:

  MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
  HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
  STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
  PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL

• Sequence length: 298

Pathways

KEGG:

FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Cellular senescence
Progesterone-mediated oocyte maturation
Cushing syndrome
Hepatitis C
Hepatitis B
Measles
Human papillomavirus infection
Human T-cell leukemia virus 1 infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancer
Gastric cancer

Reactome:

G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
Transcriptional regulation of granulopoiesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	21804548
Carcinoma of the head and neck	Squamous cell carcinoma of the head and neck	rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001, rs786201838, rs587782144, rs866775781, rs730882008, rs1567549584, rs1597371666, rs1597365075	29464035
Diffuse lymphoma	Diffuse Large B-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291
Glioblastoma	Glioblastoma Multiforme	rs121913500, rs886042842, rs1555138291, rs1558518449, rs1567176006, rs1558650888
Melanoma	melanoma	rs121913315, rs121913323, rs137853080, rs137853081, rs121909232, rs121913388, rs104894094, rs1563902635, rs104894095, rs104894097, rs104894098, rs104894099, rs104894109, rs137854599, rs11547328, rs104894340, rs398123152, rs587780668, rs587782083, rs587782206, rs587782792, rs180177042, rs121913381, rs730881675, rs730881674, rs730881677, rs730881673, rs1800586, rs768966657, rs587778189, rs786204195, rs121913321, rs45476696, rs864622636, rs864622263, rs869025340, rs876660436, rs876658534, rs876658556, rs878853647, rs878853644, rs878853650, rs886041162, rs121913389, rs1057519852, rs121913384, rs121913387, rs1060501266, rs1060501263, rs1060501262, rs749714198, rs1060501265, rs559848002, rs1064794292, rs1131691187, rs1131691186, rs199907548, rs1554654052, rs1554656411, rs1554656624, rs1554653915, rs1554653956, rs1554656253, rs1554654224, rs754806883, rs1057520039, rs1563889584, rs1563889685, rs1287464120, rs1563888944, rs1563892715, rs1563889847, rs141798398, rs1587332338, rs1587340291, rs11552823, rs561034503, rs138677674, rs1819962958, rs1820531050	21559390

Unknown
Disease name	Disease term	dbSNP ID	References
B-cell lymphoma	Adult Diffuse Large B-Cell Lymphoma
Hodgkin disease	Hodgkin Disease
Polycystic ovary syndrome	Polycystic Ovary Syndrome		22885925