ARFRP1 (ARF related protein 1)

Gene

• Entrez ID: 10139
• Gene name: ARF related protein 1
• Gene symbol: ARFRP1
• Synonyms: ARL18, ARP, Arp1
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: The protein encoded by this gene is a membrane-associated GTP-ase which localizes to the plasma membrane and is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This gene plays a role in membrane trafficking between the trans-Golg

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029524	hsa-miR-26b-5p	Microarray	19088304
MIRT793297	hsa-miR-103a	CLIP-seq
MIRT793298	hsa-miR-107	CLIP-seq
MIRT793299	hsa-miR-1225-3p	CLIP-seq
MIRT793300	hsa-miR-1226	CLIP-seq
MIRT793301	hsa-miR-125a-5p	CLIP-seq
MIRT793302	hsa-miR-125b	CLIP-seq
MIRT793303	hsa-miR-1294	CLIP-seq
MIRT793304	hsa-miR-15a	CLIP-seq
MIRT793305	hsa-miR-15b	CLIP-seq
MIRT793306	hsa-miR-16	CLIP-seq
MIRT793307	hsa-miR-185	CLIP-seq
MIRT793308	hsa-miR-1915	CLIP-seq
MIRT793309	hsa-miR-195	CLIP-seq
MIRT793310	hsa-miR-214	CLIP-seq
MIRT793311	hsa-miR-298	CLIP-seq
MIRT793312	hsa-miR-3121-3p	CLIP-seq
MIRT793313	hsa-miR-3180	CLIP-seq
MIRT793314	hsa-miR-3180-3p	CLIP-seq
MIRT793315	hsa-miR-3194-5p	CLIP-seq
MIRT793316	hsa-miR-3196	CLIP-seq
MIRT793317	hsa-miR-3202	CLIP-seq
MIRT793318	hsa-miR-330-3p	CLIP-seq
MIRT793319	hsa-miR-331-3p	CLIP-seq
MIRT793320	hsa-miR-3591-3p	CLIP-seq
MIRT793321	hsa-miR-361-3p	CLIP-seq
MIRT793322	hsa-miR-3619-5p	CLIP-seq
MIRT793323	hsa-miR-3622a-3p	CLIP-seq
MIRT793324	hsa-miR-3622b-3p	CLIP-seq
MIRT793325	hsa-miR-3663-3p	CLIP-seq
MIRT793326	hsa-miR-3675-5p	CLIP-seq
MIRT793327	hsa-miR-3918	CLIP-seq
MIRT793328	hsa-miR-3973	CLIP-seq
MIRT793329	hsa-miR-424	CLIP-seq
MIRT793330	hsa-miR-4254	CLIP-seq
MIRT793331	hsa-miR-4268	CLIP-seq
MIRT793332	hsa-miR-4287	CLIP-seq
MIRT793333	hsa-miR-4291	CLIP-seq
MIRT793334	hsa-miR-4293	CLIP-seq
MIRT793335	hsa-miR-4300	CLIP-seq
MIRT793336	hsa-miR-4306	CLIP-seq
MIRT793337	hsa-miR-4308	CLIP-seq
MIRT793338	hsa-miR-4319	CLIP-seq
MIRT793339	hsa-miR-4323	CLIP-seq
MIRT793340	hsa-miR-4436b-3p	CLIP-seq
MIRT793341	hsa-miR-4459	CLIP-seq
MIRT793342	hsa-miR-4468	CLIP-seq
MIRT793343	hsa-miR-4469	CLIP-seq
MIRT793344	hsa-miR-4512	CLIP-seq
MIRT793345	hsa-miR-4520a-3p	CLIP-seq
MIRT793346	hsa-miR-4530	CLIP-seq
MIRT793347	hsa-miR-4644	CLIP-seq
MIRT793348	hsa-miR-4652-5p	CLIP-seq
MIRT793349	hsa-miR-4660	CLIP-seq
MIRT793350	hsa-miR-4685-3p	CLIP-seq
MIRT793351	hsa-miR-4685-5p	CLIP-seq
MIRT793352	hsa-miR-4690-3p	CLIP-seq
MIRT793353	hsa-miR-4691-3p	CLIP-seq
MIRT793354	hsa-miR-4691-5p	CLIP-seq
MIRT793355	hsa-miR-4695-5p	CLIP-seq
MIRT793356	hsa-miR-4706	CLIP-seq
MIRT793357	hsa-miR-4710	CLIP-seq
MIRT793358	hsa-miR-4717-5p	CLIP-seq
MIRT793359	hsa-miR-4726-3p	CLIP-seq
MIRT793360	hsa-miR-4747-5p	CLIP-seq
MIRT793361	hsa-miR-4749-3p	CLIP-seq
MIRT793362	hsa-miR-4749-5p	CLIP-seq
MIRT793363	hsa-miR-4755-3p	CLIP-seq
MIRT793364	hsa-miR-4779	CLIP-seq
MIRT793365	hsa-miR-4786-3p	CLIP-seq
MIRT793366	hsa-miR-483-3p	CLIP-seq
MIRT793367	hsa-miR-497	CLIP-seq
MIRT793368	hsa-miR-513a-5p	CLIP-seq
MIRT793369	hsa-miR-548a-5p	CLIP-seq
MIRT793370	hsa-miR-548ab	CLIP-seq
MIRT793371	hsa-miR-548ak	CLIP-seq
MIRT793372	hsa-miR-548b-3p	CLIP-seq
MIRT793373	hsa-miR-548b-5p	CLIP-seq
MIRT793374	hsa-miR-548c-5p	CLIP-seq
MIRT793375	hsa-miR-548d-5p	CLIP-seq
MIRT793376	hsa-miR-548h	CLIP-seq
MIRT793377	hsa-miR-548i	CLIP-seq
MIRT793378	hsa-miR-548j	CLIP-seq
MIRT793379	hsa-miR-548w	CLIP-seq
MIRT793380	hsa-miR-548y	CLIP-seq
MIRT793381	hsa-miR-559	CLIP-seq
MIRT793382	hsa-miR-617	CLIP-seq
MIRT793383	hsa-miR-646	CLIP-seq
MIRT793384	hsa-miR-665	CLIP-seq
MIRT793385	hsa-miR-761	CLIP-seq
MIRT793386	hsa-miR-802	CLIP-seq
MIRT793387	hsa-miR-920	CLIP-seq
MIRT793388	hsa-miR-922	CLIP-seq
MIRT1545474	hsa-miR-4313	CLIP-seq
MIRT1934110	hsa-miR-3915	CLIP-seq
MIRT1934111	hsa-miR-3928	CLIP-seq
MIRT1934112	hsa-miR-4325	CLIP-seq
MIRT1934113	hsa-miR-4494	CLIP-seq
MIRT1934114	hsa-miR-4499	CLIP-seq
MIRT1934115	hsa-miR-450b-5p	CLIP-seq
MIRT793344	hsa-miR-4512	CLIP-seq
MIRT1934116	hsa-miR-507	CLIP-seq
MIRT1934117	hsa-miR-557	CLIP-seq
MIRT2173966	hsa-miR-146b-3p	CLIP-seq
MIRT2173967	hsa-miR-188-3p	CLIP-seq
MIRT2173968	hsa-miR-339-5p	CLIP-seq
MIRT2173969	hsa-miR-3679-3p	CLIP-seq
MIRT2173970	hsa-miR-3909	CLIP-seq
MIRT2173971	hsa-miR-4446-3p	CLIP-seq
MIRT2173972	hsa-miR-4449	CLIP-seq
MIRT2173973	hsa-miR-4650-5p	CLIP-seq
MIRT2173974	hsa-miR-4675	CLIP-seq
MIRT793352	hsa-miR-4690-3p	CLIP-seq
MIRT793358	hsa-miR-4717-5p	CLIP-seq
MIRT2173975	hsa-miR-4740-3p	CLIP-seq
MIRT2173976	hsa-miR-4741	CLIP-seq
MIRT793366	hsa-miR-483-3p	CLIP-seq
MIRT2173977	hsa-miR-485-5p	CLIP-seq
MIRT2384367	hsa-miR-1254	CLIP-seq
MIRT2384368	hsa-miR-3116	CLIP-seq
MIRT793317	hsa-miR-3202	CLIP-seq
MIRT2384369	hsa-miR-4476	CLIP-seq
MIRT2384370	hsa-miR-515-3p	CLIP-seq
MIRT2384371	hsa-miR-519e	CLIP-seq
MIRT2384372	hsa-miR-550a	CLIP-seq
MIRT2384373	hsa-miR-661	CLIP-seq
MIRT2477574	hsa-miR-1285	CLIP-seq
MIRT2477575	hsa-miR-1321	CLIP-seq
MIRT2173967	hsa-miR-188-3p	CLIP-seq
MIRT2477576	hsa-miR-1909	CLIP-seq
MIRT2477577	hsa-miR-1973	CLIP-seq
MIRT2477578	hsa-miR-1976	CLIP-seq
MIRT2477579	hsa-miR-3117-5p	CLIP-seq
MIRT2477580	hsa-miR-3187-5p	CLIP-seq
MIRT2173970	hsa-miR-3909	CLIP-seq
MIRT1934110	hsa-miR-3915	CLIP-seq
MIRT1934111	hsa-miR-3928	CLIP-seq
MIRT2477581	hsa-miR-4270	CLIP-seq
MIRT2477582	hsa-miR-4441	CLIP-seq
MIRT2173971	hsa-miR-4446-3p	CLIP-seq
MIRT1934113	hsa-miR-4494	CLIP-seq
MIRT1934114	hsa-miR-4499	CLIP-seq
MIRT2173974	hsa-miR-4675	CLIP-seq
MIRT2477583	hsa-miR-4722-3p	CLIP-seq
MIRT2477584	hsa-miR-4739	CLIP-seq
MIRT2173975	hsa-miR-4740-3p	CLIP-seq
MIRT2173976	hsa-miR-4741	CLIP-seq
MIRT2477585	hsa-miR-4751	CLIP-seq
MIRT2477586	hsa-miR-4756-5p	CLIP-seq
MIRT2477587	hsa-miR-550b	CLIP-seq
MIRT2477588	hsa-miR-612	CLIP-seq
MIRT2477589	hsa-miR-615-5p	CLIP-seq
MIRT2173967	hsa-miR-188-3p	CLIP-seq
MIRT2477578	hsa-miR-1976	CLIP-seq
MIRT793315	hsa-miR-3194-5p	CLIP-seq
MIRT2173970	hsa-miR-3909	CLIP-seq
MIRT1934110	hsa-miR-3915	CLIP-seq
MIRT1934111	hsa-miR-3928	CLIP-seq
MIRT2173971	hsa-miR-4446-3p	CLIP-seq
MIRT1934113	hsa-miR-4494	CLIP-seq
MIRT1934114	hsa-miR-4499	CLIP-seq
MIRT2173974	hsa-miR-4675	CLIP-seq
MIRT793352	hsa-miR-4690-3p	CLIP-seq
MIRT2477583	hsa-miR-4722-3p	CLIP-seq
MIRT2173975	hsa-miR-4740-3p	CLIP-seq
MIRT2173976	hsa-miR-4741	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	TAS	8530503
GO:0005515	Function	Protein binding	IPI
GO:0005525	Function	GTP binding	IEA
GO:0005794	Component	Golgi apparatus	IBA	21873635
GO:0005794	Component	Golgi apparatus	IDA	19224922
GO:0005802	Component	Trans-Golgi network	IDA	16129887
GO:0005829	Component	Cytosol	TAS
GO:0006886	Process	Intracellular protein transport	IBA	21873635
GO:0007165	Process	Signal transduction	TAS	8530503
GO:0007369	Process	Gastrulation	IEA
GO:0016020	Component	Membrane	TAS	8530503
GO:0032588	Component	Trans-Golgi network membrane	TAS
GO:0033365	Process	Protein localization to organelle	IBA	21873635
GO:0034067	Process	Protein localization to Golgi apparatus	IMP	19224922
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	16129887
GO:0043001	Process	Golgi to plasma membrane protein transport	IBA	21873635
GO:0043001	Process	Golgi to plasma membrane protein transport	IMP	16129887, 19224922

Other IDs

• MIM: 604699
• HGNC: 662
• e!Ensembl: ENSG00000101246

Protein

• UniProt ID: Q13795
• Protein name: ADP-ribosylation factor-related protein 1 (ARF-related protein 1) (ARP)
• Protein function: Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. {ECO:00
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00025	Arf	4 → 187	ADP-ribosylation factor family	Domain

• Sequence:

  MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKNYKGMSLSKITTTVGLN
  IGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDSTDEERLAESKQAFEKVVT
  SEALCGVPVLVLANKQDVETCLSIPDIKTAFSDCTSKIGRRDCLTQACSALTGKGVREGI
  EWMVKCVVRNVHRPPRQRDIT

• Sequence length: 201

Pathways

Reactome:

Retrograde transport at the Trans-Golgi-Network

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243