CDH13 (cadherin 13)

Gene

• Entrez ID: 1012
• Gene name: Cadherin 13
• Gene symbol: CDH13
• Synonyms: CDHH, P105
• Chromosome: 16
• Chromosome location: 16q23.3
• Summary: This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT021007	hsa-miR-155-5p	Proteomics	18668040
MIRT024070	hsa-miR-1-3p	Proteomics	18668040
MIRT053689	hsa-miR-181a-5p	Microarray	22942087
MIRT617196	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT617195	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT617194	hsa-miR-31-3p	HITS-CLIP	23824327
MIRT617193	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT617192	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT617191	hsa-miR-4307	HITS-CLIP	23824327
MIRT617190	hsa-miR-4464	HITS-CLIP	23824327
MIRT617196	hsa-miR-1266-3p	HITS-CLIP	23824327
MIRT617195	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT617194	hsa-miR-31-3p	HITS-CLIP	23824327
MIRT617193	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT617192	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT617191	hsa-miR-4307	HITS-CLIP	23824327
MIRT617190	hsa-miR-4464	HITS-CLIP	23824327
MIRT879678	hsa-miR-147b	CLIP-seq
MIRT879679	hsa-miR-1254	CLIP-seq
MIRT879678	hsa-miR-147b	CLIP-seq
MIRT879680	hsa-miR-3064-5p	CLIP-seq
MIRT879681	hsa-miR-3116	CLIP-seq
MIRT879682	hsa-miR-323b-5p	CLIP-seq
MIRT879683	hsa-miR-329	CLIP-seq
MIRT879684	hsa-miR-362-3p	CLIP-seq
MIRT879685	hsa-miR-3652	CLIP-seq
MIRT879686	hsa-miR-3688-5p	CLIP-seq
MIRT879687	hsa-miR-4289	CLIP-seq
MIRT879688	hsa-miR-4430	CLIP-seq
MIRT879689	hsa-miR-4474-3p	CLIP-seq
MIRT879690	hsa-miR-4505	CLIP-seq
MIRT879691	hsa-miR-4535	CLIP-seq
MIRT879692	hsa-miR-4800-5p	CLIP-seq
MIRT879693	hsa-miR-492	CLIP-seq
MIRT879694	hsa-miR-548n	CLIP-seq
MIRT879695	hsa-miR-616	CLIP-seq
MIRT879696	hsa-miR-661	CLIP-seq
MIRT2500604	hsa-miR-130a	CLIP-seq
MIRT2500605	hsa-miR-130b	CLIP-seq
MIRT879678	hsa-miR-147b	CLIP-seq
MIRT2500606	hsa-miR-153	CLIP-seq
MIRT2500607	hsa-miR-185	CLIP-seq
MIRT2500608	hsa-miR-19a	CLIP-seq
MIRT2500609	hsa-miR-19b	CLIP-seq
MIRT2500610	hsa-miR-301a	CLIP-seq
MIRT2500611	hsa-miR-301b	CLIP-seq
MIRT2500612	hsa-miR-3150b-3p	CLIP-seq
MIRT2500613	hsa-miR-3613-5p	CLIP-seq
MIRT2500614	hsa-miR-3650	CLIP-seq
MIRT2500615	hsa-miR-3666	CLIP-seq
MIRT2500616	hsa-miR-3682-3p	CLIP-seq
MIRT2500617	hsa-miR-376c	CLIP-seq
MIRT2500618	hsa-miR-4282	CLIP-seq
MIRT2500619	hsa-miR-4295	CLIP-seq
MIRT2500620	hsa-miR-4306	CLIP-seq
MIRT2500621	hsa-miR-4419a	CLIP-seq
MIRT2500622	hsa-miR-448	CLIP-seq
MIRT2500623	hsa-miR-4510	CLIP-seq
MIRT2500624	hsa-miR-454	CLIP-seq
MIRT2500625	hsa-miR-4644	CLIP-seq
MIRT2500626	hsa-miR-4689	CLIP-seq
MIRT2500627	hsa-miR-4699-3p	CLIP-seq
MIRT2500628	hsa-miR-4779	CLIP-seq
MIRT2500629	hsa-miR-4784	CLIP-seq
MIRT2500630	hsa-miR-519a	CLIP-seq
MIRT2500631	hsa-miR-519b-3p	CLIP-seq
MIRT2500632	hsa-miR-519c-3p	CLIP-seq
MIRT2500633	hsa-miR-552	CLIP-seq
MIRT2500634	hsa-miR-664	CLIP-seq
MIRT2500635	hsa-miR-668	CLIP-seq
MIRT2500636	hsa-miR-764	CLIP-seq
MIRT2500614	hsa-miR-3650	CLIP-seq
MIRT2500616	hsa-miR-3682-3p	CLIP-seq
MIRT2500618	hsa-miR-4282	CLIP-seq
MIRT2500635	hsa-miR-668	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
POU3F2	Unknown	23069940

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0001938	Process	Positive regulation of endothelial cell proliferation	IMP	15364621
GO:0001954	Process	Positive regulation of cell-matrix adhesion	IMP	17573778
GO:0002040	Process	Sprouting angiogenesis	IBA	21873635
GO:0002040	Process	Sprouting angiogenesis	IDA	16873731
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005576	Component	Extracellular region	HDA	27068509
GO:0005615	Component	Extracellular space	IDA	16873731
GO:0005737	Component	Cytoplasm	IDA	10737605
GO:0005886	Component	Plasma membrane	IDA	10737605
GO:0005886	Component	Plasma membrane	TAS
GO:0005901	Component	Caveola	IDA	9650591
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IDA	10601632
GO:0007162	Process	Negative regulation of cell adhesion	IDA	14729458
GO:0007266	Process	Rho protein signal transduction	IMP	15703273
GO:0008285	Process	Negative regulation of cell population proliferation	IDA	10737605
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA	10601632
GO:0016342	Component	Catenin complex	IBA	21873635
GO:0016601	Process	Rac protein signal transduction	IMP	15703273
GO:0030032	Process	Lamellipodium assembly	IDA	15703273
GO:0030100	Process	Regulation of endocytosis	IMP	17573778
GO:0030169	Function	Low-density lipoprotein particle binding	IDA	16013438
GO:0030335	Process	Positive regulation of cell migration	IDA	14729458
GO:0031225	Component	Anchored component of membrane	IEA
GO:0034332	Process	Adherens junction organization	TAS
GO:0042058	Process	Regulation of epidermal growth factor receptor signaling pathway	IMP	17573778
GO:0042803	Function	Protein homodimerization activity	IEA
GO:0043005	Component	Neuron projection	IDA	10737605
GO:0043542	Process	Endothelial cell migration	IDA	14729458
GO:0043616	Process	Keratinocyte proliferation	IDA	15816843
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0045296	Function	Cadherin binding	IDA	10601632
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IMP	16099944
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IMP	15364621
GO:0050850	Process	Positive regulation of calcium-mediated signaling	IDA	16013438
GO:0050927	Process	Positive regulation of positive chemotaxis	IDA	16013438
GO:0051668	Process	Localization within membrane	IMP	17573778
GO:0055096	Process	Low-density lipoprotein particle mediated signaling	IDA	16013438
GO:0055100	Function	Adiponectin binding	ISS
GO:0062023	Component	Collagen-containing extracellular matrix	HDA	27559042
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0071813	Function	Lipoprotein particle binding	IDA	11027617
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA	21873635
GO:0098982	Component	GABA-ergic synapse	IEA

Other IDs

• MIM: 601364
• HGNC: 1753
• e!Ensembl: ENSG00000140945

Protein

• UniProt ID: P55290
• Protein name: Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)
• Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regu
• PDB: 2V37
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08758	Cadherin_pro	26 → 112	Cadherin prodomain like	Domain
  PF00028	Cadherin	143 → 236	Cadherin domain	Domain
  PF00028	Cadherin	250 → 354	Cadherin domain	Domain
  PF00028	Cadherin	368 → 469	Cadherin domain	Domain
  PF00028	Cadherin	483 → 576	Cadherin domain	Domain
  PF00028	Cadherin	588 → 680	Cadherin domain	Domain

• Sequence:

  MQPRTPLVLCVLLSQVLLLTSAEDLDCTPGFQQKVFHINQPAEFIEDQSILNLTFSDCKG
  NDKLRYEVSSPYFKVNSDGGLVALRNITAVGKTLFVHARTPHAEDMAELVIVGGKDIQGS
  LQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGV
  DQEPKGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQND
  NRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFY
  IDPEKGDIVTVVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHS
  PKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTN
  EGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPD
  PMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTAVLD
  RESPFVDNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAPFIYPTVAEVCDDAKNLS
  VVILGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKANYNLPIM
  VTDSGKPPMTNITDLRVQVCSCRNSKVDCNAAGALRFSLPSVLLLSLFSLACL

• Sequence length: 713

Pathways

Reactome:

Adherens junctions interactions

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	26830138
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	26503814
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	29212778, 30104761, 28714975, 28714974
Esophagus neoplasm	Esophageal Neoplasms, Malignant neoplasm of esophagus	rs28934578, rs121918714, rs1567556006, rs1575166666	18729198
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	27182965
Leukemia	Leukemia, Myelocytic, Acute	rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297, rs11978267, rs4132601	27903959
Lung carcinoma	Non-Small Cell Lung Carcinoma	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	18337602
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	18337602
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	18264096, 17288544
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23358160

Unknown
Disease name	Disease term	dbSNP ID	References
Barrett epithelium	Barrett Epithelium		18729198
Barrett esophagus	Barrett Esophagus	rs41341748	18729198
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	28067908
Erectile dysfunction	Erectile dysfunction		30583798
Liver carcinoma	Liver carcinoma		18425332, 28284560, 18553387
Lung neoplasms	Lung Neoplasms		18337602
Mental depression	Mental Depression, Depressive disorder	rs587778876, rs587778877	22064162
Prostatic neoplasms	Prostatic Neoplasms		17288544, 18264096