CDH12 (cadherin 12)

Gene

• Entrez ID: 1010
• Gene name: Cadherin 12
• Gene symbol: CDH12
• Synonyms: CDHB
• Chromosome: 5
• Chromosome location: 5p14.3
• Summary: This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023018	hsa-miR-124-3p	Microarray	18668037
MIRT608795	hsa-miR-759	HITS-CLIP	24906430
MIRT608794	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT608793	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608792	hsa-miR-8068	HITS-CLIP	24906430
MIRT608791	hsa-miR-6818-5p	HITS-CLIP	24906430
MIRT608790	hsa-miR-147a	HITS-CLIP	24906430
MIRT608789	hsa-miR-5010-3p	HITS-CLIP	24906430
MIRT608788	hsa-miR-4455	HITS-CLIP	24906430
MIRT608790	hsa-miR-147a	HITS-CLIP	27418678
MIRT608790	hsa-miR-147a	HITS-CLIP	27418678
MIRT608790	hsa-miR-147a	HITS-CLIP	27418678
MIRT608790	hsa-miR-147a	HITS-CLIP	27418678
MIRT608788	hsa-miR-4455	HITS-CLIP	27418678
MIRT608788	hsa-miR-4455	HITS-CLIP	27418678
MIRT608788	hsa-miR-4455	HITS-CLIP	27418678
MIRT608788	hsa-miR-4455	HITS-CLIP	27418678
MIRT608789	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608789	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608789	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608789	hsa-miR-5010-3p	HITS-CLIP	27418678
MIRT608794	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608794	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608794	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608794	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608791	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608791	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608791	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608791	hsa-miR-6818-5p	HITS-CLIP	27418678
MIRT608793	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608793	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608793	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608793	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT608795	hsa-miR-759	HITS-CLIP	27418678
MIRT608795	hsa-miR-759	HITS-CLIP	27418678
MIRT608792	hsa-miR-8068	HITS-CLIP	27418678
MIRT608792	hsa-miR-8068	HITS-CLIP	27418678
MIRT608792	hsa-miR-8068	HITS-CLIP	27418678
MIRT608792	hsa-miR-8068	HITS-CLIP	27418678
MIRT879343	hsa-miR-129-5p	CLIP-seq
MIRT879344	hsa-miR-1302	CLIP-seq
MIRT879345	hsa-miR-3122	CLIP-seq
MIRT879346	hsa-miR-3913-5p	CLIP-seq
MIRT879347	hsa-miR-3978	CLIP-seq
MIRT879348	hsa-miR-4298	CLIP-seq
MIRT879349	hsa-miR-4777-5p	CLIP-seq
MIRT879350	hsa-miR-518d-5p	CLIP-seq
MIRT879351	hsa-miR-519b-5p	CLIP-seq
MIRT879352	hsa-miR-519c-5p	CLIP-seq
MIRT879353	hsa-miR-520c-5p	CLIP-seq
MIRT879354	hsa-miR-526a	CLIP-seq
MIRT1960650	hsa-miR-1276	CLIP-seq
MIRT1960651	hsa-miR-142-5p	CLIP-seq
MIRT1960652	hsa-miR-3125	CLIP-seq
MIRT1960653	hsa-miR-3183	CLIP-seq
MIRT1960654	hsa-miR-340	CLIP-seq
MIRT1960655	hsa-miR-3916	CLIP-seq
MIRT1960656	hsa-miR-4311	CLIP-seq
MIRT1960657	hsa-miR-4723-3p	CLIP-seq
MIRT1960658	hsa-miR-4753-3p	CLIP-seq
MIRT1960659	hsa-miR-583	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA	21873635
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005886	Component	Plasma membrane	TAS
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0007043	Process	Cell-cell junction assembly	IBA	21873635
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007275	Process	Multicellular organism development	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	21873635
GO:0016342	Component	Catenin complex	IBA	21873635
GO:0034332	Process	Adherens junction organization	IBA	21873635
GO:0034332	Process	Adherens junction organization	TAS
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA	21873635

Other IDs

• MIM: 600562
• HGNC: 1751
• e!Ensembl: ENSG00000154162

Protein

• UniProt ID: P55289
• Protein name: Cadherin-12 (Brain cadherin) (BR-cadherin) (Neural type cadherin 2) (N-cadherin 2)
• Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00028	Cadherin	59 → 151	Cadherin domain	Domain
  PF00028	Cadherin	165 → 260	Cadherin domain	Domain
  PF00028	Cadherin	274 → 376	Cadherin domain	Domain
  PF00028	Cadherin	389 → 480	Cadherin domain	Domain
  PF00028	Cadherin	493 → 590	Cadherin domain	Domain
  PF01049	Cadherin_C	638 → 785	Cadherin cytoplasmic region	Family

• Sequence:

  MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ
  FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE
  EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL
  QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK
  DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
  NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH
  SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY
  FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL
  DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV
  RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
  CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY
  DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR
  LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD
  MFGEEESYNPDKVT

• Sequence length: 794

Pathways

Reactome:

Adherens junctions interactions

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Multiple myeloma	Multiple Myeloma	rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962, rs751524927, rs1575079076, rs1575446356, rs1478603808, rs1578264146, rs1578673280, rs1579484570, rs1579491104, rs1171390403, rs1582867955, rs764264135, rs951047896, rs890521687, rs1581495906, rs1587941402, rs1003155450, rs1588299621, rs1591100766, rs1591693095, rs1029296641, rs1593107841, rs1208575764, rs1593835248, rs1594406727, rs1594966387, rs1595889508, rs1159294530, rs1597073318, rs1135402871, rs1599413207, rs1418268495, rs1212577459, rs1600394490, rs1455074519, rs1603113792, rs1603415028, rs1602247047, rs1603452612	23502783
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29662167

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		29662167