IQCJ-SCHIP1 (IQCJ-SCHIP1 readthrough)

Gene

• Entrez ID: 100505385
• Gene name: IQCJ-SCHIP1 readthrough
• Gene symbol: IQCJ-SCHIP1
• Synonyms: -
• Chromosome: 3
• Chromosome location: 3q25.32-q25.33
• Summary: This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript variants that are composed of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1069698	hsa-miR-181a	CLIP-seq
MIRT1069699	hsa-miR-181b	CLIP-seq
MIRT1069700	hsa-miR-181c	CLIP-seq
MIRT1069701	hsa-miR-181d	CLIP-seq
MIRT1069702	hsa-miR-196a	CLIP-seq
MIRT1069703	hsa-miR-196b	CLIP-seq
MIRT1069704	hsa-miR-4262	CLIP-seq
MIRT1069705	hsa-miR-4698	CLIP-seq
MIRT1069706	hsa-miR-4719	CLIP-seq
MIRT1069707	hsa-miR-505	CLIP-seq
MIRT1069708	hsa-miR-513b	CLIP-seq
MIRT1069709	hsa-miR-543	CLIP-seq
MIRT1069710	hsa-miR-129-5p	CLIP-seq
MIRT1069711	hsa-miR-1827	CLIP-seq
MIRT1069712	hsa-miR-940	CLIP-seq
MIRT1550179	hsa-miR-139-5p	CLIP-seq
MIRT1069711	hsa-miR-1827	CLIP-seq
MIRT1550180	hsa-miR-4277	CLIP-seq
MIRT1550181	hsa-miR-4659a-3p	CLIP-seq
MIRT1550182	hsa-miR-4659b-3p	CLIP-seq
MIRT1550183	hsa-miR-4778-3p	CLIP-seq
MIRT1550184	hsa-miR-548a-3p	CLIP-seq
MIRT1550185	hsa-miR-548e	CLIP-seq
MIRT1550186	hsa-miR-548f	CLIP-seq
MIRT1550187	hsa-miR-582-5p	CLIP-seq
MIRT1069712	hsa-miR-940	CLIP-seq
MIRT2017159	hsa-miR-200b	CLIP-seq
MIRT2017160	hsa-miR-200c	CLIP-seq
MIRT2017161	hsa-miR-3153	CLIP-seq
MIRT2017162	hsa-miR-429	CLIP-seq
MIRT2017163	hsa-miR-452	CLIP-seq
MIRT2017164	hsa-miR-4668-5p	CLIP-seq
MIRT2017165	hsa-miR-4676-3p	CLIP-seq
MIRT2249125	hsa-miR-4729	CLIP-seq
MIRT1069710	hsa-miR-129-5p	CLIP-seq
MIRT1069711	hsa-miR-1827	CLIP-seq
MIRT1069712	hsa-miR-940	CLIP-seq
MIRT1550184	hsa-miR-548a-3p	CLIP-seq
MIRT1550185	hsa-miR-548e	CLIP-seq
MIRT1550186	hsa-miR-548f	CLIP-seq
MIRT2552706	hsa-miR-140-3p	CLIP-seq
MIRT2552707	hsa-miR-141	CLIP-seq
MIRT2552708	hsa-miR-200a	CLIP-seq
MIRT2552709	hsa-miR-2117	CLIP-seq
MIRT2552710	hsa-miR-3145-3p	CLIP-seq
MIRT2552711	hsa-miR-326	CLIP-seq
MIRT2552712	hsa-miR-330-5p	CLIP-seq
MIRT2552713	hsa-miR-4273	CLIP-seq
MIRT2552714	hsa-miR-4310	CLIP-seq
MIRT2552715	hsa-miR-4453	CLIP-seq
MIRT2552716	hsa-miR-4538	CLIP-seq
MIRT2552717	hsa-miR-4677-5p	CLIP-seq
MIRT2552718	hsa-miR-4766-3p	CLIP-seq
MIRT2552719	hsa-miR-544	CLIP-seq
MIRT2552720	hsa-miR-548p	CLIP-seq
MIRT2552706	hsa-miR-140-3p	CLIP-seq
MIRT2552707	hsa-miR-141	CLIP-seq
MIRT2552708	hsa-miR-200a	CLIP-seq
MIRT2552710	hsa-miR-3145-3p	CLIP-seq
MIRT2552714	hsa-miR-4310	CLIP-seq
MIRT2552718	hsa-miR-4766-3p	CLIP-seq
MIRT2552719	hsa-miR-544	CLIP-seq
MIRT2552720	hsa-miR-548p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25950943
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0030054	Component	Cell junction	IBA	21873635
GO:0035332	Process	Positive regulation of hippo signaling	IBA	21873635
GO:0043194	Component	Axon initial segment	ISS
GO:0051494	Process	Negative regulation of cytoskeleton organization	IMP	25950943

Other IDs

• MIM: HGNC
• e!Ensembl: HGNC

Protein

• UniProt ID: B3KU38
• Protein name: IQCJ-SCHIP1 readthrough transcript protein
• Protein function: May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarit
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15157	IQCJ-SCHIP1	4 → 146	Fusion protein IQCJ-SCHIP1 with IQ-like motif	Family
  PF10148	SCHIP-1	331 → 560	Schwannomin-interacting protein 1	Family

• Sequence:

  MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREY
  LQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRAS
  SQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEE
  DERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNG
  NVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDW
  EALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSK
  SGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDT
  TEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPH
  ISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLV
  DIEDLTRHAESQQKHMAEKMPAK

• Sequence length: 563

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	30373671

Unknown
Disease name	Disease term	dbSNP ID	References
Oral ulcer	Oral Ulcer		30837455