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TOM1L1 (target of myb1 like 1 membrane trafficking protein)

Gene

10040

Target of myb1 like 1 membrane trafficking protein

TOM1L1

SRCASM

17q22

Show/Hide all(192)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002599	hsa-miR-124-3p	Microarray	15685193
MIRT002599	hsa-miR-124-3p	Microarray;Other	15685193
MIRT049735	hsa-miR-92a-3p	CLASH	23622248
MIRT1446253	hsa-miR-130a	CLIP-seq
MIRT1446254	hsa-miR-130b	CLIP-seq
MIRT1446255	hsa-miR-135a	CLIP-seq
MIRT1446256	hsa-miR-135b	CLIP-seq
MIRT1446257	hsa-miR-142-5p	CLIP-seq
MIRT1446258	hsa-miR-181a	CLIP-seq
MIRT1446259	hsa-miR-181b	CLIP-seq
MIRT1446260	hsa-miR-181c	CLIP-seq
MIRT1446261	hsa-miR-181d	CLIP-seq
MIRT1446262	hsa-miR-186	CLIP-seq
MIRT1446263	hsa-miR-19a	CLIP-seq
MIRT1446264	hsa-miR-19b	CLIP-seq
MIRT1446265	hsa-miR-301a	CLIP-seq
MIRT1446266	hsa-miR-301b	CLIP-seq
MIRT1446267	hsa-miR-3119	CLIP-seq
MIRT1446268	hsa-miR-3133	CLIP-seq
MIRT1446269	hsa-miR-3159	CLIP-seq
MIRT1446270	hsa-miR-340	CLIP-seq
MIRT1446271	hsa-miR-3666	CLIP-seq
MIRT1446272	hsa-miR-374a	CLIP-seq
MIRT1446273	hsa-miR-374b	CLIP-seq
MIRT1446274	hsa-miR-4262	CLIP-seq
MIRT1446275	hsa-miR-4272	CLIP-seq
MIRT1446276	hsa-miR-4295	CLIP-seq
MIRT1446277	hsa-miR-454	CLIP-seq
MIRT1446278	hsa-miR-4781-3p	CLIP-seq
MIRT1446279	hsa-miR-4799-5p	CLIP-seq
MIRT1446280	hsa-miR-489	CLIP-seq
MIRT1446281	hsa-miR-514	CLIP-seq
MIRT1446282	hsa-miR-514b-3p	CLIP-seq
MIRT1446283	hsa-miR-519a	CLIP-seq
MIRT1446284	hsa-miR-519b-3p	CLIP-seq
MIRT1446285	hsa-miR-519c-3p	CLIP-seq
MIRT2133418	hsa-miR-1227	CLIP-seq
MIRT1446255	hsa-miR-135a	CLIP-seq
MIRT1446256	hsa-miR-135b	CLIP-seq
MIRT1446258	hsa-miR-181a	CLIP-seq
MIRT1446259	hsa-miR-181b	CLIP-seq
MIRT1446260	hsa-miR-181c	CLIP-seq
MIRT1446261	hsa-miR-181d	CLIP-seq
MIRT2133419	hsa-miR-216a	CLIP-seq
MIRT1446267	hsa-miR-3119	CLIP-seq
MIRT2133420	hsa-miR-3174	CLIP-seq
MIRT2133421	hsa-miR-3182	CLIP-seq
MIRT2133422	hsa-miR-375	CLIP-seq
MIRT1446274	hsa-miR-4262	CLIP-seq
MIRT2133423	hsa-miR-4493	CLIP-seq
MIRT2133424	hsa-miR-4521	CLIP-seq
MIRT2133425	hsa-miR-4528	CLIP-seq
MIRT2133426	hsa-miR-455-5p	CLIP-seq
MIRT2133427	hsa-miR-4659a-3p	CLIP-seq
MIRT2133428	hsa-miR-4659b-3p	CLIP-seq
MIRT2133429	hsa-miR-4670-3p	CLIP-seq
MIRT2133430	hsa-miR-4715-3p	CLIP-seq
MIRT2133431	hsa-miR-4759	CLIP-seq
MIRT2133432	hsa-miR-4775	CLIP-seq
MIRT1446278	hsa-miR-4781-3p	CLIP-seq
MIRT1446280	hsa-miR-489	CLIP-seq
MIRT2133433	hsa-miR-496	CLIP-seq
MIRT1446281	hsa-miR-514	CLIP-seq
MIRT1446282	hsa-miR-514b-3p	CLIP-seq
MIRT2133434	hsa-miR-590-3p	CLIP-seq
MIRT2133435	hsa-miR-873	CLIP-seq
MIRT2354602	hsa-miR-1200	CLIP-seq
MIRT2133418	hsa-miR-1227	CLIP-seq
MIRT2354603	hsa-miR-1229	CLIP-seq
MIRT2354604	hsa-miR-124	CLIP-seq
MIRT1446253	hsa-miR-130a	CLIP-seq
MIRT1446254	hsa-miR-130b	CLIP-seq
MIRT1446255	hsa-miR-135a	CLIP-seq
MIRT1446256	hsa-miR-135b	CLIP-seq
MIRT1446257	hsa-miR-142-5p	CLIP-seq
MIRT1446258	hsa-miR-181a	CLIP-seq
MIRT1446259	hsa-miR-181b	CLIP-seq
MIRT1446260	hsa-miR-181c	CLIP-seq
MIRT1446261	hsa-miR-181d	CLIP-seq
MIRT1446262	hsa-miR-186	CLIP-seq
MIRT1446263	hsa-miR-19a	CLIP-seq
MIRT1446264	hsa-miR-19b	CLIP-seq
MIRT2354605	hsa-miR-23a	CLIP-seq
MIRT2354606	hsa-miR-23b	CLIP-seq
MIRT2354607	hsa-miR-23c	CLIP-seq
MIRT1446265	hsa-miR-301a	CLIP-seq
MIRT1446266	hsa-miR-301b	CLIP-seq
MIRT2354608	hsa-miR-3117-5p	CLIP-seq
MIRT1446267	hsa-miR-3119	CLIP-seq
MIRT1446268	hsa-miR-3133	CLIP-seq
MIRT2354609	hsa-miR-3140-5p	CLIP-seq
MIRT1446269	hsa-miR-3159	CLIP-seq
MIRT2354610	hsa-miR-3160-5p	CLIP-seq
MIRT2133420	hsa-miR-3174	CLIP-seq
MIRT2133421	hsa-miR-3182	CLIP-seq
MIRT1446270	hsa-miR-340	CLIP-seq
MIRT2354611	hsa-miR-342-3p	CLIP-seq
MIRT2354612	hsa-miR-3646	CLIP-seq
MIRT1446271	hsa-miR-3666	CLIP-seq
MIRT2354613	hsa-miR-369-3p	CLIP-seq
MIRT2354614	hsa-miR-374c	CLIP-seq
MIRT2133422	hsa-miR-375	CLIP-seq
MIRT2354615	hsa-miR-376a	CLIP-seq
MIRT2354616	hsa-miR-376b	CLIP-seq
MIRT2354617	hsa-miR-425	CLIP-seq
MIRT1446274	hsa-miR-4262	CLIP-seq
MIRT2354618	hsa-miR-4263	CLIP-seq
MIRT1446275	hsa-miR-4272	CLIP-seq
MIRT1446276	hsa-miR-4295	CLIP-seq
MIRT2354619	hsa-miR-4328	CLIP-seq
MIRT2354620	hsa-miR-4418	CLIP-seq
MIRT2354621	hsa-miR-4427	CLIP-seq
MIRT2354622	hsa-miR-4476	CLIP-seq
MIRT2133423	hsa-miR-4493	CLIP-seq
MIRT2133424	hsa-miR-4521	CLIP-seq
MIRT1446277	hsa-miR-454	CLIP-seq
MIRT2133426	hsa-miR-455-5p	CLIP-seq
MIRT2133427	hsa-miR-4659a-3p	CLIP-seq
MIRT2133428	hsa-miR-4659b-3p	CLIP-seq
MIRT2133429	hsa-miR-4670-3p	CLIP-seq
MIRT2133430	hsa-miR-4715-3p	CLIP-seq
MIRT2133431	hsa-miR-4759	CLIP-seq
MIRT2133432	hsa-miR-4775	CLIP-seq
MIRT1446278	hsa-miR-4781-3p	CLIP-seq
MIRT2354623	hsa-miR-4797-3p	CLIP-seq
MIRT1446279	hsa-miR-4799-5p	CLIP-seq
MIRT1446280	hsa-miR-489	CLIP-seq
MIRT2354624	hsa-miR-491-3p	CLIP-seq
MIRT2354625	hsa-miR-494	CLIP-seq
MIRT2133433	hsa-miR-496	CLIP-seq
MIRT2354626	hsa-miR-506	CLIP-seq
MIRT2354627	hsa-miR-509-3-5p	CLIP-seq
MIRT2354628	hsa-miR-509-5p	CLIP-seq
MIRT1446281	hsa-miR-514	CLIP-seq
MIRT1446282	hsa-miR-514b-3p	CLIP-seq
MIRT1446283	hsa-miR-519a	CLIP-seq
MIRT1446284	hsa-miR-519b-3p	CLIP-seq
MIRT1446285	hsa-miR-519c-3p	CLIP-seq
MIRT2354629	hsa-miR-576-5p	CLIP-seq
MIRT2133434	hsa-miR-590-3p	CLIP-seq
MIRT2354630	hsa-miR-630	CLIP-seq
MIRT2354631	hsa-miR-655	CLIP-seq
MIRT2354632	hsa-miR-944	CLIP-seq
MIRT2354603	hsa-miR-1229	CLIP-seq
MIRT1446258	hsa-miR-181a	CLIP-seq
MIRT1446259	hsa-miR-181b	CLIP-seq
MIRT1446260	hsa-miR-181c	CLIP-seq
MIRT1446261	hsa-miR-181d	CLIP-seq
MIRT2354605	hsa-miR-23a	CLIP-seq
MIRT2354606	hsa-miR-23b	CLIP-seq
MIRT2354607	hsa-miR-23c	CLIP-seq
MIRT2354610	hsa-miR-3160-5p	CLIP-seq
MIRT2354611	hsa-miR-342-3p	CLIP-seq
MIRT1446274	hsa-miR-4262	CLIP-seq
MIRT2354619	hsa-miR-4328	CLIP-seq
MIRT2354624	hsa-miR-491-3p	CLIP-seq
MIRT2133424	hsa-miR-4521	CLIP-seq
MIRT2133431	hsa-miR-4759	CLIP-seq
MIRT2133432	hsa-miR-4775	CLIP-seq
MIRT2133434	hsa-miR-590-3p	CLIP-seq
MIRT2648441	hsa-miR-1267	CLIP-seq
MIRT2648442	hsa-miR-203	CLIP-seq
MIRT2133419	hsa-miR-216a	CLIP-seq
MIRT2133420	hsa-miR-3174	CLIP-seq
MIRT2133421	hsa-miR-3182	CLIP-seq
MIRT2133422	hsa-miR-375	CLIP-seq
MIRT2133424	hsa-miR-4521	CLIP-seq
MIRT2648443	hsa-miR-4652-3p	CLIP-seq
MIRT2133427	hsa-miR-4659a-3p	CLIP-seq
MIRT2133428	hsa-miR-4659b-3p	CLIP-seq
MIRT2133429	hsa-miR-4670-3p	CLIP-seq
MIRT2133431	hsa-miR-4759	CLIP-seq
MIRT2133432	hsa-miR-4775	CLIP-seq
MIRT2133433	hsa-miR-496	CLIP-seq
MIRT2133434	hsa-miR-590-3p	CLIP-seq
MIRT2648444	hsa-miR-653	CLIP-seq
MIRT2648441	hsa-miR-1267	CLIP-seq
MIRT2648442	hsa-miR-203	CLIP-seq
MIRT2133419	hsa-miR-216a	CLIP-seq
MIRT2133420	hsa-miR-3174	CLIP-seq
MIRT2133421	hsa-miR-3182	CLIP-seq
MIRT2133422	hsa-miR-375	CLIP-seq
MIRT2133424	hsa-miR-4521	CLIP-seq
MIRT2648443	hsa-miR-4652-3p	CLIP-seq
MIRT2133427	hsa-miR-4659a-3p	CLIP-seq
MIRT2133428	hsa-miR-4659b-3p	CLIP-seq
MIRT2133429	hsa-miR-4670-3p	CLIP-seq
MIRT2133431	hsa-miR-4759	CLIP-seq
MIRT2133432	hsa-miR-4775	CLIP-seq
MIRT2133433	hsa-miR-496	CLIP-seq
MIRT2133434	hsa-miR-590-3p	CLIP-seq
MIRT2648444	hsa-miR-653	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15611048, 16412388, 18654987, 19798056, 20936779, 21903422, 21988832
GO:0005737	Component	Cytoplasm	IDA	16412388
GO:0005764	Component	Lysosome	TAS	10329004
GO:0005768	Component	Endosome	IBA	21873635
GO:0005768	Component	Endosome	IDA	15611048, 16412388
GO:0005795	Component	Golgi stack	IEA
GO:0005829	Component	Cytosol	IDA	15611048
GO:0006886	Process	Intracellular protein transport	IEA
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007165	Process	Signal transduction	IDA	16479011
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IBA	21873635
GO:0017124	Function	SH3 domain binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	16479011
GO:0030276	Function	Clathrin binding	IBA	21873635
GO:0030276	Function	Clathrin binding	IDA	16412388
GO:0030295	Function	Protein kinase activator activity	IEA
GO:0031954	Process	Positive regulation of protein autophosphorylation	IDA	16479011
GO:0032147	Process	Activation of protein kinase activity	IDA	16479011
GO:0043130	Function	Ubiquitin binding	TAS	15611048
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	15611048
GO:0045839	Process	Negative regulation of mitotic nuclear division	IDA	16479011
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:2000278	Process	Regulation of DNA biosynthetic process	IDA	16479011

MIM	HGNC	e!Ensembl
604701	11983	ENSG00000141198

Protein

UniProt ID

O75674

Protein name

TOM1-like protein 1 (Src-activating and signaling molecule protein) (Target of Myb-like protein 1)

Protein function

Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions

PDB

3RRU

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00790	VHS	9 → 150	VHS domain	Domain
PF03127	GAT	213 → 289	GAT domain	Domain

Sequence

MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRI
SKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRIL
NFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPT
APALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQ
KLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQ
KEATNTTSEPSAPSQDLLDLSPSPRMPRATLGELNTMNNQLSGLNFSLPSSDVTNNLKPS
LHPQMNLLALENTEIPPFAQRTSQNLTSSHAYDNFLEHSNSVFLQPVSLQTIAAAPSNQS
LPPLPSNHPAMTKSDLQPPNYYEVMEFDPLAPAVTTEAIYEEIDAHQHKGAQNDGD

Sequence length

476

Interactions

View interactions

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881

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