CDH4 (cadherin 4)

Gene

• Entrez ID: 1002
• Gene name: Cadherin 4
• Gene symbol: CDH4
• Synonyms: CAD4, R-CAD, RCAD
• Chromosome: 20
• Chromosome location: 20q13.33
• Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. B

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs765815715	G>A,C	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023656	hsa-miR-1-3p	Microarray	18668037
MIRT624382	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624381	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624380	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624379	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT624378	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT659651	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT624377	hsa-miR-623	HITS-CLIP	23824327
MIRT624376	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624375	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624374	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624382	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624381	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624380	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624379	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT624378	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT659651	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT624377	hsa-miR-623	HITS-CLIP	23824327
MIRT624376	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624375	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624374	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624382	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624381	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624380	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624379	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT624378	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT624377	hsa-miR-623	HITS-CLIP	23824327
MIRT624376	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624375	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624374	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624382	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624381	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624380	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624379	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT624378	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT659651	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT624377	hsa-miR-623	HITS-CLIP	23824327
MIRT624376	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624375	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624374	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624382	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624381	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624380	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624379	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT624378	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT659651	hsa-miR-570-3p	HITS-CLIP	23824327
MIRT624377	hsa-miR-623	HITS-CLIP	23824327
MIRT624376	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624375	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624374	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT624382	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT624381	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT624380	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT624379	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT624378	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT624377	hsa-miR-623	HITS-CLIP	23824327
MIRT624376	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT624375	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT624374	hsa-miR-7111-3p	HITS-CLIP	23824327
MIRT1921550	hsa-miR-520f	CLIP-seq
MIRT1921551	hsa-miR-548ac	CLIP-seq
MIRT1921552	hsa-miR-548ae	CLIP-seq
MIRT1921553	hsa-miR-548aj	CLIP-seq
MIRT1921554	hsa-miR-548am	CLIP-seq
MIRT1921555	hsa-miR-548d-3p	CLIP-seq
MIRT1921556	hsa-miR-548x	CLIP-seq
MIRT1921557	hsa-miR-548z	CLIP-seq
MIRT2500679	hsa-miR-148a	CLIP-seq
MIRT2500680	hsa-miR-148b	CLIP-seq
MIRT2500681	hsa-miR-152	CLIP-seq
MIRT2500682	hsa-miR-205	CLIP-seq
MIRT2500683	hsa-miR-4276	CLIP-seq
MIRT2500684	hsa-miR-515-3p	CLIP-seq
MIRT2500685	hsa-miR-519e	CLIP-seq
MIRT2500686	hsa-miR-626	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0007155	Process	Cell adhesion	TAS	2059658
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA	21873635
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA
GO:0007411	Process	Axon guidance	IEA
GO:0016342	Component	Catenin complex	IBA	21873635
GO:0034332	Process	Adherens junction organization	TAS
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0045773	Process	Positive regulation of axon extension	IEA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA	21873635

Other IDs

• MIM: 603006
• HGNC: 1763
• e!Ensembl: ENSG00000179242

Protein

• UniProt ID: P55283
• Protein name: Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)
• Protein function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08758	Cadherin_pro	30 → 120	Cadherin prodomain like	Domain
  PF00028	Cadherin	174 → 268	Cadherin domain	Domain
  PF00028	Cadherin	282 → 383	Cadherin domain	Domain
  PF00028	Cadherin	397 → 499	Cadherin domain	Domain
  PF00028	Cadherin	512 → 606	Cadherin domain	Domain
  PF01049	Cadherin_C	760 → 913	Cadherin cytoplasmic region	Family

• Sequence:

  MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFS
  SCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLL
  VAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPE
  NSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEH
  ASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVT
  ANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQ
  ATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQ
  PHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPL
  ASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQ
  AVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGT
  LQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRK
  NWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCT
  TIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNI
  LKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPG
  DIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWG
  PRFKKLADMYGGGEED

• Sequence length: 916

Pathways

KEGG:

Cell adhesion molecules

Reactome:

Adherens junctions interactions
Myogenesis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Sarcoidosis	Sarcoidosis	rs2076530	19165924

Unknown
Disease name	Disease term	dbSNP ID	References
Impaired cognition	Impaired cognition		26252872
Sleep apnea	Sleep Apnea, Obstructive		26977737