# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 02:31:06
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "succinic semialdehyde dehydrogenase deficiency" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Crohn disease	succinic semialdehyde dehydrogenase deficiency	1	1	ALDH5A1 (2)	0.00145	1.00000	4.481e-2	4.657e-2	
Arthrogryposis multiplex congenita	succinic semialdehyde dehydrogenase deficiency	1	1	ALDH5A1 (2)	0.01370	1.00000	4.676e-3	5.787e-3	
Pena-shokeir syndrome 	succinic semialdehyde dehydrogenase deficiency	1	1	ALDH5A1 (2)	0.01887	1.00000	3.377e-3	4.374e-3	
Dystonia	succinic semialdehyde dehydrogenase deficiency	1	1	ALDH5A1 (3)	0.02222	1.00000	2.858e-3	3.806e-3	
Brain disease	succinic semialdehyde dehydrogenase deficiency	1	1	ALDH5A1 (3)	0.02326	1.00000	2.728e-3	3.665e-3