# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 14:33:00
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:00:13. Filters applied: disease name contains "primrose syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
primrose syndrome	Stevens-johnson syndrome	1	1	ZBTB20 (2)	0.01266	1.00000	5.066e-3	6.200e-3	
primrose syndrome	Toxic epidermal necrolysis	1	1	ZBTB20 (2)	0.02632	1.00000	2.403e-3	3.312e-3	
Clinodactyly	primrose syndrome	1	1	ZBTB20 (2)	0.05263	1.00000	1.169e-3	1.895e-3	
Post-operative atrial fibrillation	primrose syndrome	1	1	ZBTB20 (2)	0.16667	1.00000	3.247e-4	7.705e-4	
Intellectual developmental disorder cataracts myopathy	primrose syndrome	1	1	ZBTB20 (2)	0.50000	1.00000	6.494e-5	2.329e-4