# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 06:58:37
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Amyotrophic lateral sclerosis	inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	1	1	HNRNPA2B1 (3)	0.00300	1.00000	2.156e-2	2.336e-2	
Frontotemporal dementia	inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	1	1	HNRNPA2B1 (2)	0.01639	1.00000	3.897e-3	4.941e-3	
inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	T-cell leukemia-lymphoma	1	1	HNRNPA2B1 (2)	0.02703	1.00000	2.338e-3	3.243e-3	
inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Vacuolar myopathy	1	1	HNRNPA2B1 (2)	0.16667	1.00000	3.247e-4	7.709e-4	
inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Oculopharyngeal muscular dystrophy	1	1	HNRNPA2B1 (5)	0.33333	1.00000	1.299e-4	3.931e-4