# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 23:07:12
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "immunodeficiency 84" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
immunodeficiency 84	Selective iga deficiency disease	1	1	IKZF3 (2)	0.03125	1.00000	2.013e-3	2.901e-3	
immunodeficiency 84	Nasal disorder	1	1	IKZF3 (2)	0.04167	1.00000	1.494e-3	2.313e-3	
Gastro-entero-pancreatic neuroendocrine tumor	immunodeficiency 84	1	1	IKZF3 (2)	0.06250	1.00000	9.742e-4	1.665e-3	
B-cell chronic lymphocytic leukemia	immunodeficiency 84	1	1	IKZF3 (2)	0.11111	1.00000	5.195e-4	1.061e-3	
Combined immunodeficiency-lymphopenia-cancer predisposing syndrome due to aiolos deficiency	immunodeficiency 84	1	1	IKZF3 (2)	0.50000	1.00000	6.494e-5	2.331e-4