# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 22:27:36
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Centronuclear myopathy	immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome	1	1	FOXP3 (2)	0.04348	1.00000	1.429e-3	2.226e-3	
Hydranencephaly	immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome	1	1	FOXP3 (2)	0.04348	1.00000	1.429e-3	2.226e-3	
Hydrops fetalis	immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome	1	1	FOXP3 (2)	0.05882	1.00000	1.039e-3	1.739e-3	
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome	Occupational dermatitis	1	1	FOXP3 (3)	0.11111	1.00000	5.195e-4	1.061e-3	
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome	Insulin dependent diabetes mellitus secretory diarrhea syndrome	1	1	FOXP3 (3)	0.25000	1.00000	1.948e-4	5.354e-4