# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 17:31:14
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "glomerulopathy with fibronectin deposits 2" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Focal glomerulosclerosis	glomerulopathy with fibronectin deposits 2	1	1	FN1 (2)	0.01724	1.00000	3.702e-3	4.735e-3	
glomerulopathy with fibronectin deposits 2	Hypertrophy	1	1	FN1 (2)	0.02000	1.00000	3.182e-3	4.168e-3	
glomerulopathy with fibronectin deposits 2	Urethral obstruction	1	1	FN1 (2)	0.03704	1.00000	1.689e-3	2.531e-3	
glomerulopathy with fibronectin deposits 2	Spondylometaphyseal dysplasia	1	1	FN1 (6)	0.06667	1.00000	9.092e-4	1.576e-3	
glomerulopathy with fibronectin deposits 2	spondylometaphyseal dysplasia, 'corner fracture' type	1	0	FN1 (1)	0.50000	1.00000	6.494e-5	2.331e-4