# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 07:48:00
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "genetic developmental and epileptic encephalopathy" (8 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Complex partial epilepsy	genetic developmental and epileptic encephalopathy	1	1	SCN3A (3)	0.02703	1.00000	2.338e-3	3.243e-3	
Congenital brain dysgenesis due to glutamine synthetase deficiency	genetic developmental and epileptic encephalopathy	1	1	GLUL (5)	0.02703	1.00000	2.338e-3	3.243e-3	
genetic developmental and epileptic encephalopathy	self-limited familial neonatal epilepsy	1	0	KCNQ3 (1)	0.02703	1.00000	2.338e-3	3.243e-3	
Epilepsy of infancy with migrating focal seizures	genetic developmental and epileptic encephalopathy	4	4	SCN1A (2), SLC12A5 (3), PLCB1 (2), SLC25A22 (2)	0.09524	0.44444	3.144e-9	2.700e-8	
genetic developmental and epileptic encephalopathy	Malignant migrating partial seizures of infancy	4	4	SCN1A (3), SLC12A5 (3), PLCB1 (3), SLC25A22 (3)	0.09524	0.44444	3.144e-9	2.700e-8	
genetic developmental and epileptic encephalopathy	Rolandic epilepsy	8	8	WWOX (2), SZT2 (2), SCN1A (2), SCN1B (2), KCNQ3 (2), CSTB (2), PLCB1 (2), SPTAN1 (2)	0.10526	0.22222	1.142e-13	1.469e-12	
genetic developmental and epileptic encephalopathy	West syndrome	8	8	WWOX (2), SIK1 (2), ARX (2), SCN1A (2), DNM1 (2), STXBP1 (2), PLCB1 (2), SPTAN1 (2)	0.13559	0.26667	2.185e-15	3.189e-14	
Developmental and epileptic encephalopathy	genetic developmental and epileptic encephalopathy	36	36	WWOX (6), ABAT (3), CACNA1E (6), CUX2 (6), PACS2 (6), SIK1 (6), SYNJ1 (6), SZT2 (7), GLUL (6), RYR3 (3), ITPA (6), GABRB3 (6)	0.16290	1.00000	1.904e-68	1.339e-66