# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 12:56:21
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "Tyrosine hydroxylase–deficient dopa-responsive dystonia" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Catalepsy	Tyrosine hydroxylase–deficient dopa-responsive dystonia	1	1	TH (3)	0.05556	0.50000	2.077e-3	2.969e-3	
Dyskinesia, drug-induced	Tyrosine hydroxylase–deficient dopa-responsive dystonia	1	1	TH (3)	0.05882	0.50000	1.947e-3	2.828e-3	
Delirium	Tyrosine hydroxylase–deficient dopa-responsive dystonia	1	1	TH (2)	0.08333	0.50000	1.298e-3	2.063e-3	
Dystonia, dopa-responsive, with or without hyperphenylalaninemia	Tyrosine hydroxylase–deficient dopa-responsive dystonia	1	1	TSPOAP1 (2)	0.16667	0.50000	5.195e-4	1.061e-3	
Tyrosine hydroxylase deficiency	Tyrosine hydroxylase–deficient dopa-responsive dystonia	1	1	TH (3)	0.33333	1.00000	1.299e-4	3.931e-4