# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-21 12:58:37
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-21 12:58:11. Filters applied: disease name contains "Poirier-bienvenu neurodevelopmental syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Nonsyndromic intellectual disability	Poirier-bienvenu neurodevelopmental syndrome	1	1	CSNK2B (5)	0.00699	1.00000	9.168e-3	1.032e-2	
Poirier-bienvenu neurodevelopmental syndrome	Syndactyly	1	1	CSNK2B (3)	0.03846	1.00000	1.614e-3	2.265e-3	
Clinodactyly	Poirier-bienvenu neurodevelopmental syndrome	1	1	CSNK2B (3)	0.04545	1.00000	1.356e-3	1.966e-3	
Cutaneous lupus erythematosus	Poirier-bienvenu neurodevelopmental syndrome	1	1	CSNK2B (3)	0.08333	1.00000	7.102e-4	1.174e-3	
Malocclusion	Poirier-bienvenu neurodevelopmental syndrome	1	1	CSNK2B (3)	0.16667	1.00000	3.228e-4	6.413e-4