# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 15:10:44
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "POLR1C-related disorder" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Hearing loss	POLR1C-related disorder	1	1	POLR1C (2)	0.00258	1.00000	2.513e-2	2.687e-2	
Cerebellar ataxia	POLR1C-related disorder	1	1	POLR1C (2)	0.00870	1.00000	7.404e-3	8.700e-3	
Hypomyelinating leukodystrophy	POLR1C-related disorder	1	1	POLR1C (6)	0.03226	1.00000	1.948e-3	2.828e-3	
Mandibulofacial dysostosis	POLR1C-related disorder	1	1	POLR1C (3)	0.12500	1.00000	4.546e-4	9.726e-4	
POLR1C-related disorder	Treacher collins syndrome	1	1	POLR1C (5)	0.20000	1.00000	2.598e-4	6.509e-4