# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 07:22:58
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Cerebellar ataxia	Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline	1	1	CAPRIN1 (3)	0.00820	1.00000	7.813e-3	8.931e-3	
Moyamoya angiopathy	Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline	1	1	CAPRIN1 (3)	0.02703	1.00000	2.324e-3	3.054e-3	
Myoclonic epilepsy	Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline	1	1	CAPRIN1 (3)	0.04000	1.00000	1.550e-3	2.192e-3	
Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline	Post-operative acute kidney injury	1	1	CAPRIN1 (3)	0.08333	1.00000	7.102e-4	1.174e-3	
Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline	Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder	1	1	CAPRIN1 (2)	0.50000	1.00000	6.457e-5	1.985e-4