# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-11 21:08:20
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "Nephronophthisis-like nephropathy" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Nephronophthisis-like nephropathy	Prostate cancer	1	1	SLC41A1 (4)	0.00104	0.50000	1.209e-1	1.222e-1	
Nephronophthisis-like nephropathy	Parkinson disease	1	1	SLC41A1 (4)	0.00188	0.50000	6.753e-2	6.898e-2	
Kidney disease	Nephronophthisis-like nephropathy	2	2	XPNPEP3 (6), SLC41A1 (5)	0.00469	1.00000	7.601e-4	1.405e-3	
kidney disorder	Nephronophthisis-like nephropathy	1	1	SLC41A1 (5)	0.33333	1.00000	1.299e-4	3.931e-4	
Nephronophthisis	Nephronophthisis-like nephropathy	2	2	XPNPEP3 (6), SLC41A1 (4)	0.04878	1.00000	6.580e-6	3.342e-5