# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-21 18:58:10
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-21 12:58:11. Filters applied: disease name contains "Joint hyperlaxity" (10 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Congenital muscular dystrophy	Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome	1	1	TRIP4 (4)	0.04167	1.00000	1.485e-3	2.122e-3	
Centronuclear myopathy	Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome	1	1	TRIP4 (2)	0.04348	1.00000	1.420e-3	2.040e-3	
Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome	Pericarditis	1	1	TRIP4 (2)	0.05000	1.00000	1.227e-3	1.809e-3	
Joint hyperlaxity	Laryngeal disease	1	1	IPO8 (2)	0.12500	0.50000	7.747e-4	1.247e-3	
Joint hyperlaxity	Vissers-bodmer syndrome	1	1	IPO8 (5)	0.20000	0.50000	3.874e-4	7.329e-4	
Allergy	Joint hyperlaxity	1	0	IPO8 (1)	0.25000	0.50000	2.583e-4	5.385e-4	
Duane-radial ray syndrome	Joint hyperlaxity	1	1	IPO8 (2)	0.25000	0.50000	2.583e-4	5.385e-4	
Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome	Prenatal spinal muscular atrophy and congenital bone fractures	1	0	TRIP4 (1)	0.33333	1.00000	1.291e-4	3.269e-4	
Joint hyperlaxity	Viss syndrome	1	0	IPO8 (1)	0.33333	1.00000	1.291e-4	3.269e-4	
Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome	Spinal muscular atrophy with congenital bone fractures 1	1	0	TRIP4 (1)	0.50000	1.00000	6.457e-5	1.985e-4