# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 04:46:53
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Frontotemporal dementia	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	1	1	HNRNPA2B1 (3)	0.01613	1.00000	3.939e-3	4.834e-3	
Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Seminoma	1	1	HNRNPA2B1 (2)	0.01887	1.00000	3.357e-3	4.219e-3	
Extragonadal nonseminomatous germ cell tumor	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	1	1	HNRNPA2B1 (2)	0.10000	1.00000	5.811e-4	1.000e-3	
Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Vacuolar myopathy	1	1	HNRNPA2B1 (3)	0.16667	1.00000	3.228e-4	6.412e-4	
Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 2	Oculopharyngeal muscular dystrophy	1	1	HNRNPA2B1 (6)	0.33333	1.00000	1.291e-4	3.269e-4