# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-12 06:57:13
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-12 03:00:13. Filters applied: disease name contains "Epilepsy with auditory features" (7 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Epilepsy with auditory features	Familial focal epilepsy with variable foci	1	1	DEPDC5 (4)	0.08333	0.25000	2.077e-3	2.969e-3	
Epilepsy with auditory features	Focal epilepsy	1	1	DEPDC5 (3)	0.12500	0.25000	1.039e-3	1.739e-3	
Epilepsy with auditory features	lissencephaly with cerebellar hypoplasia	1	1	RELN (3)	0.16667	0.50000	5.195e-4	1.061e-3	
Epilepsy with auditory features	Sacroiliac arthritis	1	1	RELN (3)	0.20000	1.00000	2.598e-4	6.509e-4	
Epilepsy with auditory features	Sacroiliac joint synovitis	1	1	RELN (3)	0.20000	1.00000	2.598e-4	6.509e-4	
Epilepsy with auditory features	Familial temporal lobe epilepsy	3	3	RELN (5), LGI1 (7), MICAL1 (5)	0.33333	0.75000	2.301e-10	2.206e-9	
Epilepsy with auditory features	Lateral temporal lobe epilepsy	3	3	RELN (3), DEPDC5 (2), LGI1 (4)	0.50000	0.75000	2.630e-11	2.771e-10