# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 12:56:24
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "Early-onset immune dysregulation with autoimmunity due to dock11 partial deficiency" (3 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Diabetes mellitus type 2	Early-onset immune dysregulation with autoimmunity due to dock11 partial deficiency	1	1	DOCK11 (3)	0.00032	1.00000	2.000e-1	2.002e-1	
Autoinflammatory disease, multisystem, with immune dysregulation, x-linked	Early-onset immune dysregulation with autoimmunity due to dock11 partial deficiency	1	1	DOCK11 (5)	0.50000	1.00000	6.494e-5	2.331e-4	
Early-onset immune dysregulation due to dock11 complete deficiency	Early-onset immune dysregulation with autoimmunity due to dock11 partial deficiency	1	1	DOCK11 (2)	0.50000	1.00000	6.494e-5	2.331e-4