# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 15:10:36
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "Dend syndrome" (6 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Dend syndrome	Diazoxide-resistant focal hyperinsulinism due to sulfonylurea receptor 1 deficiency	1	1	ABCC8 (4)	0.25000	1.00000	1.948e-4	5.354e-4	
Dend syndrome	hyperinsulinemic hypoglycemia, familial, 1	1	1	ABCC8 (4)	0.25000	1.00000	1.948e-4	5.354e-4	
Dend syndrome	Diazoxide-resistant focal hyperinsulinism due to kir6.2 deficiency	1	1	KCNJ11 (4)	0.25000	1.00000	1.948e-4	5.354e-4	
Dend syndrome	hyperinsulinemic hypoglycemia, familial, 2	1	1	KCNJ11 (5)	0.25000	1.00000	1.948e-4	5.354e-4	
Dend syndrome	Hyperinsulinemic hypoglycemia	2	2	ABCC8 (5), KCNJ11 (6)	0.15385	0.66667	1.391e-6	7.964e-6	
Congenital hyperinsulinism	Dend syndrome	2	2	ABCC8 (3), KCNJ11 (5)	0.25000	0.66667	3.795e-7	2.393e-6