# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 22:24:24
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "Combined immunodeficiency, x-linked" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Combined immunodeficiency, x-linked	Sezary syndrome	1	1	IL2RG (3)	0.03448	0.50000	3.504e-3	4.517e-3	
Combined immunodeficiency, x-linked	Omenn syndrome	1	1	IL2RG (5)	0.08333	0.50000	1.298e-3	2.063e-3	
Combined immunodeficiency, x-linked	X-linked severe combined immunodeficiency	1	1	IL2RG (2)	0.33333	1.00000	1.299e-4	3.931e-4	
Combined immunodeficiency, x-linked	T-B+ severe combined immunodeficiency due to gamma chain deficiency	1	1	IL2RG (3)	0.33333	1.00000	1.299e-4	3.931e-4	
Combined immunodeficiency, x-linked	X-linked combined immunodeficiency diseases	2	2	IL2RG (4), SASH3 (3)	0.50000	1.00000	2.531e-8	1.927e-7