# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 12:56:28
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Immunodeficiency	1	1	RNF31 (6)	0.00709	0.50000	1.797e-2	1.967e-2	
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Cardiomegaly	1	1	RBCK1 (3)	0.01163	0.50000	1.088e-2	1.226e-2	
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	Glycogen storage disease	1	1	RBCK1 (3)	0.02564	0.50000	4.800e-3	5.921e-3	
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	polyglucosan body myopathy 1 with or without immunodeficiency	1	1	RBCK1 (4)	0.33333	1.00000	1.299e-4	3.931e-4	
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis	immunodeficiency 115 with autoinflammation	1	1	RNF31 (4)	0.33333	1.00000	1.299e-4	3.931e-4