# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 08:32:27
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "neurodegeneration, childhood-onset, with cerebellar atrophy" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Congenital pontocerebellar hypoplasia	neurodegeneration, childhood-onset, with cerebellar atrophy	1	1	AGTPBP1 (2)	0.06250	1.00000	9.742e-4	1.665e-3	
Cerebellar atrophy	neurodegeneration, childhood-onset, with cerebellar atrophy	1	1	AGTPBP1 (2)	0.03226	1.00000	1.948e-3	2.828e-3	
neurodegeneration, childhood-onset, with cerebellar atrophy	Pontocerebellar hypoplasia	1	1	AGTPBP1 (3)	0.03125	1.00000	2.013e-3	2.901e-3	
Global developmental delay	neurodegeneration, childhood-onset, with cerebellar atrophy	1	1	AGTPBP1 (2)	0.00270	1.00000	2.403e-2	2.575e-2	
neurodegeneration, childhood-onset, with cerebellar atrophy	Neurodevelopmental disorder	1	1	AGTPBP1 (4)	0.00106	1.00000	6.092e-2	6.246e-2