# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 22:24:54
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "juvenile polyposis syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Bmpr1a-related juvenile polyposis	juvenile polyposis syndrome	1	1	BMPR1A (2)	0.25000	0.50000	2.598e-4	6.509e-4	
Intracranial arteriovenous malformation	juvenile polyposis syndrome	1	1	ENG (2)	0.20000	0.50000	3.896e-4	8.665e-4	
Arteriovenous hemangioma	juvenile polyposis syndrome	1	1	ENG (2)	0.16667	0.50000	5.195e-4	1.061e-3	
Cerebral saccular aneurysm	juvenile polyposis syndrome	1	1	ENG (3)	0.14286	0.50000	6.494e-4	1.241e-3	
Hereditary hemorrhagic telangiectasia	juvenile polyposis syndrome	1	1	ENG (7)	0.11111	0.50000	9.090e-4	1.576e-3