# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 18:06:39
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:00:13. Filters applied: disease name contains "hyperinsulinemic hypoglycemia with polycystic kidney disease" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
hyperinsulinemic hypoglycemia with polycystic kidney disease	PMM2-congenital disorder of glycosylation	1	0	PMM2 (1)	0.50000	1.00000	6.494e-5	2.329e-4	
Cerebral atrophy	hyperinsulinemic hypoglycemia with polycystic kidney disease	1	1	PMM2 (2)	0.12500	1.00000	4.546e-4	9.721e-4	
Hyperinsulinemic hypoglycemia	hyperinsulinemic hypoglycemia with polycystic kidney disease	1	1	PMM2 (2)	0.08333	1.00000	7.144e-4	1.335e-3	
hyperinsulinemic hypoglycemia with polycystic kidney disease	Pituitary stalk interruption syndrome	1	1	PMM2 (2)	0.03125	1.00000	2.013e-3	2.900e-3	
Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	hyperinsulinemic hypoglycemia with polycystic kidney disease	1	1	PMM2 (2)	0.02703	1.00000	2.338e-3	3.242e-3