# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 19:08:25
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-10 03:00:13. Filters applied: disease name contains "high myopia-sensorineural deafness syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Deafness and myopia	high myopia-sensorineural deafness syndrome	1	1	SLITRK6 (4)	0.50000	1.00000	6.494e-5	2.331e-4	
high myopia-sensorineural deafness syndrome	Marshall syndrome	1	1	SLITRK6 (2)	0.05000	1.00000	1.234e-3	1.986e-3	
Gestational diabetes	high myopia-sensorineural deafness syndrome	1	1	SLITRK6 (2)	0.01099	1.00000	5.845e-3	7.049e-3	
high myopia-sensorineural deafness syndrome	Lewy body disease	1	1	SLITRK6 (2)	0.01042	1.00000	6.170e-3	7.415e-3	
high myopia-sensorineural deafness syndrome	Isolated sensorineural deafness	1	1	SLITRK6 (2)	0.00833	1.00000	7.728e-3	9.016e-3