# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-09 16:24:57
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-09 03:00:13. Filters applied: disease name contains "frontorhiny" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Frontonasal dysplasia	frontorhiny	1	1	ALX3 (4)	0.12500	1.00000	4.546e-4	9.721e-4	
frontorhiny	Neural tube defects, x-linked	1	1	ALX3 (2)	0.03125	1.00000	2.013e-3	2.900e-3	
frontorhiny	Neural tube defect	1	1	ALX3 (3)	0.02041	1.00000	3.117e-3	4.095e-3	
frontorhiny	Open angle glaucoma	1	1	ALX3 (2)	0.00270	1.00000	2.396e-2	2.575e-2	
Desbuquois syndrome	frontorhiny	1	1	ALX3 (2)	0.00176	1.00000	3.682e-2	3.867e-2