# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-10 21:55:52
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-11 03:00:14. Filters applied: disease name contains "congenital myasthenic syndrome 2C" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
congenital myasthenic syndrome 2A	congenital myasthenic syndrome 2C	1	0	CHRNB1 (1)	0.50000	1.00000	6.494e-5	2.331e-4	
congenital myasthenic syndrome 2C	Postsynaptic congenital myasthenic syndrome	1	1	CHRNB1 (4)	0.07692	1.00000	7.793e-4	1.405e-3	
Congenital myasthenic syndrome	congenital myasthenic syndrome 2C	1	1	CHRNB1 (4)	0.03333	1.00000	1.883e-3	2.762e-3	
congenital myasthenic syndrome 2C	Corneal dystrophy	1	1	CHRNB1 (2)	0.03030	1.00000	2.078e-3	2.969e-3	
congenital myasthenic syndrome 2C	Myasthenic syndrome	1	1	CHRNB1 (4)	0.02439	1.00000	2.598e-3	3.514e-3