# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-14 07:29:02
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-14 03:00:13. Filters applied: disease name contains "Tremor-ataxia-central hypomyelination syndrome" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Leukodystrophy	Tremor-ataxia-central hypomyelination syndrome	2	1	POLR3B (1), POLR3A (2)	0.07407	1.00000	2.742e-6	1.489e-5	
Hypomyelinating leukodystrophy	Tremor-ataxia-central hypomyelination syndrome	2	2	POLR3B (5), POLR3A (4)	0.06452	1.00000	3.670e-6	1.952e-5	
POLR3A-related disorder	Tremor-ataxia-central hypomyelination syndrome	1	1	POLR3A (3)	0.33333	1.00000	1.299e-4	3.931e-4	
POLR3B-related disorder	Tremor-ataxia-central hypomyelination syndrome	1	1	POLR3B (2)	0.33333	1.00000	1.299e-4	3.931e-4	
Tremor-ataxia-central hypomyelination syndrome	Wiedemann-rautenstrauch syndrome	1	1	POLR3A (3)	0.33333	1.00000	1.299e-4	3.931e-4