# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 08:21:51
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Spastic paraplegia 83, autosomal recessive" (9 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Spastic paraplegia 83, autosomal recessive	1	0	HPDL (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities spastic paraplegia 83, autosomal recessive	1	0	HPDL (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities spastic paraplegia 83, autosomal recessive	Spastic paraplegia 83, autosomal recessive	1	0	HPDL (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Neurodegenerative disease	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities spastic paraplegia 83, autosomal recessive	1	0	HPDL (1)	0.02273	1.00000	2.776e-3	3.558e-3	
Neurodegenerative disease	Spastic paraplegia 83, autosomal recessive	1	0	HPDL (1)	0.02273	1.00000	2.776e-3	3.558e-3	
Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities spastic paraplegia 83, autosomal recessive	Spastic ataxia	1	1	HPDL (2)	0.01408	1.00000	4.520e-3	5.478e-3	
Spastic ataxia	Spastic paraplegia 83, autosomal recessive	1	1	HPDL (2)	0.01408	1.00000	4.520e-3	5.478e-3	
Leigh syndrome	Neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities spastic paraplegia 83, autosomal recessive	1	1	HPDL (3)	0.00909	1.00000	7.038e-3	8.163e-3	
Leigh syndrome	Spastic paraplegia 83, autosomal recessive	1	1	HPDL (3)	0.00909	1.00000	7.038e-3	8.163e-3