# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-20 06:16:13
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-20 03:00:20. Filters applied: disease name contains "Preterm premature rupture of the membranes, susceptibility to" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Osteogenesis imperfecta type 3	Preterm premature rupture of the membranes, susceptibility to	1	0	SERPINH1 (1)	0.50000	1.00000	6.457e-5	1.985e-4	
Osteogenesis imperfecta	Preterm premature rupture of the membranes, susceptibility to	1	1	SERPINH1 (7)	0.02381	1.00000	2.647e-3	3.413e-3	
Preterm premature rupture of the membranes, susceptibility to	Skeletal dysplasia	1	0	SERPINH1 (1)	0.02326	1.00000	2.712e-3	3.483e-3	
Bone fragility with contractures, arterial rupture, and deafness	Preterm premature rupture of the membranes, susceptibility to	1	1	SERPINH1 (2)	0.02000	1.00000	3.164e-3	4.003e-3	
Osteoporosis-pseudoglioma syndrome	Preterm premature rupture of the membranes, susceptibility to	1	1	SERPINH1 (2)	0.02000	1.00000	3.164e-3	4.003e-3