# GeDiPNet Shared-Gene Disease Pairs -- generated 2026-10-21 21:09:44
# Similarity: Jaccard index on shared curated genes (disease_gdp). Significance: upper-tail hypergeometric test (P(X>=k)), Benjamini-Hochberg FDR-corrected across all tested pairs. Corroborated Shared Genes: count of shared genes backed by >=2 distinct disease_gdp.main_source values combined across both diseases (e.g. GWAS-backed for one, ClinVar-backed for the other still counts); Shared Gene Names lists each gene's own source count in parentheses. Overlap Coefficient: shared genes / MIN(each disease's own total gene count) -- complements the Jaccard-based Similarity Score by showing how much of the SMALLER disease's entire known gene-set is covered by this pair, which Jaccard (dividing by the union) can understate. Shared Cluster: cluster id if both diseases fall in the same label-propagation cluster (scripts/build_disease_clusters.php), blank otherwise. See scripts/build_related.php on gedipnet.bicnirrh.res.in. Data as of: 2026-10-21 12:58:11. Filters applied: disease name contains "Prenatal spinal muscular atrophy and congenital bone fractures" (5 matching pairs).
Disease A	Disease B	Shared Genes	Corroborated Shared Genes	Shared Gene Names	Similarity Score	Overlap Coefficient	P-value	FDR Q-value	Shared Cluster
Centronuclear myopathy	Prenatal spinal muscular atrophy and congenital bone fractures	2	2	ASCC1 (2), TRIP4 (2)	0.08696	1.00000	1.926e-6	1.129e-5	
Congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome	Prenatal spinal muscular atrophy and congenital bone fractures	1	0	TRIP4 (1)	0.33333	1.00000	1.291e-4	3.269e-4	
Prenatal spinal muscular atrophy and congenital bone fractures	Spinal muscular atrophy with congenital bone fractures 2	1	0	ASCC1 (1)	0.33333	1.00000	1.291e-4	3.269e-4	
Prenatal spinal muscular atrophy and congenital bone fractures	Spinal muscular atrophy with congenital bone fractures 1	1	0	TRIP4 (1)	0.33333	1.00000	1.291e-4	3.269e-4	
Hypotonia	Prenatal spinal muscular atrophy and congenital bone fractures	1	0	ASCC1 (1)	0.11111	0.50000	9.038e-4	1.411e-3